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ZNF621 zinc finger protein 621 [ Homo sapiens (human) ]

Gene ID: 285268, updated on 23-Nov-2021

Summary

Official Symbol
ZNF621provided by HGNC
Official Full Name
zinc finger protein 621provided by HGNC
Primary source
HGNC:HGNC:24787
See related
Ensembl:ENSG00000172888
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Ubiquitous expression in thyroid (RPKM 3.3), brain (RPKM 3.1) and 25 other tissues See more
Orthologs
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Genomic context

See ZNF621 in Genome Data Viewer
Location:
3p22.1
Exon count:
7
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (40523854..40539974)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (40566451..40581273)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene RNA, U5B small nuclear 2, pseudogene Neighboring gene zinc finger protein 620 Neighboring gene ribosomal protein L5 pseudogene 10 Neighboring gene eukaryotic translation elongation factor 1 gamma pseudogene 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ23786, FLJ45246, MGC126668, DKFZp686B11107

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001098414.3NP_001091884.1  zinc finger protein 621 isoform 1

    See identical proteins and their annotated locations for NP_001091884.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Both variants 1 and 2 encode the same isoform (1).
    Source sequence(s)
    AC122683, AK127181, BC101619, N51540
    Consensus CDS
    CCDS2693.1
    UniProtKB/Swiss-Prot
    Q6ZSS3
    Related
    ENSP00000386051.2, ENST00000403205.6
    Conserved Domains (4) summary
    smart00349
    Location:1171
    KRAB; krueppel associated box
    COG4049
    Location:145198
    COG4049; Uncharacterized protein, contains archaeal-type C2H2 Zn-finger [General function prediction only]
    sd00017
    Location:265285
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:221246
    zf-H2C2_2; Zinc-finger double domain
  2. NM_001287245.2NP_001274174.1  zinc finger protein 621 isoform 2

    See identical proteins and their annotated locations for NP_001274174.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (2) has a shorter and distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC122683, AK074366, N51540
    Consensus CDS
    CCDS74920.1
    UniProtKB/Swiss-Prot
    Q6ZSS3
    Related
    ENSP00000312144.1, ENST00000310898.5
    Conserved Domains (2) summary
    smart00349
    Location:1171
    KRAB; krueppel associated box
    pfam01352
    Location:1150
    KRAB; KRAB box
  3. NM_198484.5NP_940886.1  zinc finger protein 621 isoform 1

    See identical proteins and their annotated locations for NP_940886.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1). Both variants 1 and 2 encode the same isoform.
    Source sequence(s)
    AC122683, AK127181, N51540
    Consensus CDS
    CCDS2693.1
    UniProtKB/Swiss-Prot
    Q6ZSS3
    Related
    ENSP00000340841.5, ENST00000339296.10
    Conserved Domains (4) summary
    smart00349
    Location:1171
    KRAB; krueppel associated box
    COG4049
    Location:145198
    COG4049; Uncharacterized protein, contains archaeal-type C2H2 Zn-finger [General function prediction only]
    sd00017
    Location:265285
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:221246
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

    Range
    40523854..40539974
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011533610.3XP_011531912.1  zinc finger protein 621 isoform X1

    See identical proteins and their annotated locations for XP_011531912.1

    Conserved Domains (3) summary
    COG4049
    Location:137190
    COG4049; Uncharacterized protein, contains archaeal-type C2H2 Zn-finger [General function prediction only]
    sd00017
    Location:257277
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:213238
    zf-H2C2_2; Zinc-finger double domain
  2. XM_006713114.4XP_006713177.1  zinc finger protein 621 isoform X1

    See identical proteins and their annotated locations for XP_006713177.1

    Conserved Domains (3) summary
    COG4049
    Location:137190
    COG4049; Uncharacterized protein, contains archaeal-type C2H2 Zn-finger [General function prediction only]
    sd00017
    Location:257277
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:213238
    zf-H2C2_2; Zinc-finger double domain
  3. XM_017006226.2XP_016861715.1  zinc finger protein 621 isoform X2

    Conserved Domains (3) summary
    COG4049
    Location:110163
    COG4049; Uncharacterized protein, contains archaeal-type C2H2 Zn-finger [General function prediction only]
    sd00017
    Location:230250
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:186211
    zf-H2C2_2; Zinc-finger double domain
  4. XM_005265079.4XP_005265136.1  zinc finger protein 621 isoform X1

    See identical proteins and their annotated locations for XP_005265136.1

    Conserved Domains (3) summary
    COG4049
    Location:137190
    COG4049; Uncharacterized protein, contains archaeal-type C2H2 Zn-finger [General function prediction only]
    sd00017
    Location:257277
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:213238
    zf-H2C2_2; Zinc-finger double domain
  5. XM_005265080.4XP_005265137.1  zinc finger protein 621 isoform X2

    See identical proteins and their annotated locations for XP_005265137.1

    Conserved Domains (3) summary
    COG4049
    Location:110163
    COG4049; Uncharacterized protein, contains archaeal-type C2H2 Zn-finger [General function prediction only]
    sd00017
    Location:230250
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:186211
    zf-H2C2_2; Zinc-finger double domain
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