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ZNF619 zinc finger protein 619 [ Homo sapiens (human) ]

Gene ID: 285267, updated on 5-Jan-2022

Summary

Official Symbol
ZNF619provided by HGNC
Official Full Name
zinc finger protein 619provided by HGNC
Primary source
HGNC:HGNC:26910
See related
Ensembl:ENSG00000177873
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Nov 2021]
Expression
Ubiquitous expression in thyroid (RPKM 1.6), spleen (RPKM 1.4) and 25 other tissues See more
Orthologs
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Genomic context

See ZNF619 in Genome Data Viewer
Location:
3p22.1
Exon count:
7
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (40477122..40491053)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (40518613..40532544)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 7904 Neighboring gene Sharpr-MPRA regulatory region 106 Neighboring gene ribosomal protein L14 Neighboring gene RNA, U5B small nuclear 2, pseudogene Neighboring gene zinc finger protein 620

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ90764

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in negative regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001145082.4NP_001138554.1  zinc finger protein 619 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC121754
    Consensus CDS
    CCDS46802.1
    UniProtKB/Swiss-Prot
    Q8N2I2
    Related
    ENSP00000411132.2, ENST00000447116.6
    Conserved Domains (6) summary
    smart00349
    Location:20120
    KRAB; krueppel associated box
    COG5048
    Location:256414
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:330350
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:328350
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:2059
    KRAB; KRAB box
    pfam13465
    Location:343367
    zf-H2C2_2; Zinc-finger double domain
  2. NM_001145083.3NP_001138555.1  zinc finger protein 619 isoform 5

    See identical proteins and their annotated locations for NP_001138555.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) lacks two internal coding exons, resulting in an upstream AUG start codon, as compared to variant 1. The resulting isoform (5) has a shorter and different N-terminus, as compared to isoform 1.
    Source sequence(s)
    AC121754
    Consensus CDS
    CCDS46801.1
    UniProtKB/Swiss-Prot
    Q8N2I2
    Related
    ENSP00000397232.1, ENST00000456778.5
    Conserved Domains (4) summary
    COG5048
    Location:172330
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:246266
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:244266
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:259283
    zf-H2C2_2; Zinc-finger double domain
  3. NM_001145093.4NP_001138565.1  zinc finger protein 619 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the central coding region, compared to variant 1, resulting in an isoform (2) that is shorter than isoform 1.
    Source sequence(s)
    AC121754
    Consensus CDS
    CCDS46803.1
    UniProtKB/Swiss-Prot
    Q8N2I2
    Related
    ENSP00000388710.2, ENST00000432264.4
    Conserved Domains (6) summary
    smart00349
    Location:2080
    KRAB; krueppel associated box
    COG5048
    Location:216374
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:290310
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:288310
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:2059
    KRAB; KRAB box
    pfam13465
    Location:303327
    zf-H2C2_2; Zinc-finger double domain
  4. NM_001145094.3NP_001138566.1  zinc finger protein 619 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an alternate exon and contains another alternate exon compared to variant 1. The resulting isoform (3) has a shorter and distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AC121754
    Related
    ENSP00000398024.3, ENST00000429348.6
    Conserved Domains (3) summary
    COG5048
    Location:207365
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:281301
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:434457
    zf-H2C2_2; Zinc-finger double domain
  5. NM_001363277.2NP_001350206.1  zinc finger protein 619 isoform 6

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) uses an alternate splice junction compared to variant 1. The resulting isoform (6) is shorter at the N-terminus compared to isoform 1.
    Source sequence(s)
    AC121754
    Conserved Domains (4) summary
    COG5048
    Location:158316
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:232252
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:385408
    zf-H2C2_2; Zinc-finger double domain
    cl02581
    Location:422
    KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
  6. NM_173656.5NP_775927.1  zinc finger protein 619 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC121754, DC351282
    Related
    ENSP00000322529.5, ENST00000314686.9

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

    Range
    40477122..40491053
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006713113.3XP_006713176.1  zinc finger protein 619 isoform X5

    Related
    ENST00000520737.5
    Conserved Domains (4) summary
    COG5048
    Location:171329
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:245265
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:243265
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:258282
    zf-H2C2_2; Zinc-finger double domain
  2. XM_017006225.1XP_016861714.1  zinc finger protein 619 isoform X4

    UniProtKB/TrEMBL
    Q17RW3
    Related
    ENSP00000428004.1, ENST00000522736.5
    Conserved Domains (3) summary
    COG5048
    Location:207365
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:281301
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:434457
    zf-H2C2_2; Zinc-finger double domain
  3. XM_024453461.1XP_024309229.1  zinc finger protein 619 isoform X1

    Conserved Domains (4) summary
    COG5048
    Location:327485
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:401421
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:1959
    KRAB; KRAB box
    pfam13465
    Location:414438
    zf-H2C2_2; Zinc-finger double domain
  4. XM_011533607.1XP_011531909.1  zinc finger protein 619 isoform X2

    Conserved Domains (6) summary
    smart00349
    Location:20119
    KRAB; krueppel associated box
    COG5048
    Location:255413
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:329349
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:327349
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:2059
    KRAB; KRAB box
    pfam13465
    Location:342366
    zf-H2C2_2; Zinc-finger double domain
  5. XM_006713112.2XP_006713175.1  zinc finger protein 619 isoform X3

    Conserved Domains (6) summary
    smart00349
    Location:2079
    KRAB; krueppel associated box
    COG5048
    Location:215373
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:289309
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:287309
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:2059
    KRAB; KRAB box
    pfam13465
    Location:302326
    zf-H2C2_2; Zinc-finger double domain

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001363278.1: Suppressed sequence

    Description
    NM_001363278.1: This RefSeq was removed because it was the same as NM_173656.3.
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