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HTR3E 5-hydroxytryptamine receptor 3E [ Homo sapiens (human) ]

Gene ID: 285242, updated on 2-Mar-2021

Summary

Official Symbol
HTR3Eprovided by HGNC
Official Full Name
5-hydroxytryptamine receptor 3Eprovided by HGNC
Primary source
HGNC:HGNC:24005
See related
Ensembl:ENSG00000186038 MIM:610123
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
5-HT3E; 5-HT3-E; 5-HT3c1
Summary
This locus encodes a 5-hydroxytryptamine (serotonin) receptor subunit. The encoded protein, subunit E, may play a role in neurotransmission in myenteric neurons. Genes encoding subunits C, D and E form a cluster on chromosome 3. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Feb 2012]
Expression
Low expression observed in reference dataset See more
Orthologs
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Genomic context

See HTR3E in Genome Data Viewer
Location:
3q27.1
Exon count:
9
Annotation release Status Assembly Chr Location
109.20210226 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (184097064..184106995)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (183814852..183824783)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene 5-hydroxytryptamine receptor 3C Neighboring gene EIF2B5 divergent transcript Neighboring gene 5-hydroxytryptamine receptor 3C2, pseudogene Neighboring gene HTR3E antisense RNA 1 Neighboring gene heat shock protein 90 alpha family class A member 5, pseudogene Neighboring gene eukaryotic translation initiation factor 2B subunit epsilon

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
A mega-analysis of genome-wide association studies for major depressive disorder.
GeneReviews: Not available

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC120035, MGC120036, MGC120037

Gene Ontology Provided by GOA

Function Evidence Code Pubs
neurotransmitter receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
serotonin-gated cation-selective channel activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
serotonin-gated cation-selective channel activity IDA
Inferred from Direct Assay
more info
PubMed 
transmembrane signaling receptor activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
chemical synaptic transmission IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
chemical synaptic transmission TAS
Traceable Author Statement
more info
 
ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nervous system process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of membrane potential IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
serotonin receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
neuron projection IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 
synapse IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
5-hydroxytryptamine receptor 3E
Names
5-hydroxytryptamine (serotonin) receptor 3, family member E
5-hydroxytryptamine (serotonin) receptor 3E, ionotropic
5-hydroxytryptamine receptor 3 subunit E

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_012452.1 RefSeqGene

    Range
    5001..11817
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001256613.2NP_001243542.1  5-hydroxytryptamine receptor 3E isoform d precursor

    See identical proteins and their annotated locations for NP_001243542.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) has multiple differences in the 5' UTR and coding region, compared to variant 1. These differences result in translation initiation at an alternate start codon, compared to variant 1. The encoded isoform (d) has a distinct N-terminus and is shorter than isoform a.
    Source sequence(s)
    AC131235, DQ644022
    Consensus CDS
    CCDS58868.1
    UniProtKB/Swiss-Prot
    A5X5Y0
    Related
    ENSP00000401444.2, ENST00000415389.6
    Conserved Domains (2) summary
    pfam02931
    Location:55247
    Neur_chan_LBD; Neurotransmitter-gated ion-channel ligand binding domain
    pfam02932
    Location:254353
    Neur_chan_memb; Neurotransmitter-gated ion-channel transmembrane region
  2. NM_001256614.1NP_001243543.1  5-hydroxytryptamine receptor 3E isoform e

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) lacks an alternate in-frame exon and uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. This results in a longer protein (isoform e), compared to isoform a.
    Source sequence(s)
    AC131235, AY159813, DQ644022, EU165354
    Consensus CDS
    CCDS58871.1
    UniProtKB/Swiss-Prot
    A5X5Y0
    Related
    ENSP00000406050.2, ENST00000440596.2
    Conserved Domains (2) summary
    pfam02931
    Location:70273
    Neur_chan_LBD; Neurotransmitter-gated ion-channel ligand binding domain
    pfam02932
    Location:280379
    Neur_chan_memb; Neurotransmitter-gated ion-channel transmembrane region
  3. NM_182589.2NP_872395.2  5-hydroxytryptamine receptor 3E isoform a

    See identical proteins and their annotated locations for NP_872395.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes isoform a.
    Source sequence(s)
    AC131235, AY159813
    Consensus CDS
    CCDS3251.1
    UniProtKB/Swiss-Prot
    A5X5Y0
    Related
    ENSP00000335511.2, ENST00000335304.6
    Conserved Domains (2) summary
    pfam02931
    Location:70262
    Neur_chan_LBD; Neurotransmitter-gated ion-channel ligand binding domain
    pfam02932
    Location:269368
    Neur_chan_memb; Neurotransmitter-gated ion-channel transmembrane region
  4. NM_198313.3NP_938055.1  5-hydroxytryptamine receptor 3E isoform c precursor

    See identical proteins and their annotated locations for NP_938055.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) has multiple differences in the 5' UTR and coding region, compared to variant 1. This variant encodes isoform c, which has a distinct N-terminus and is shorter than isoform a.
    Source sequence(s)
    AC131235, AY349352, DQ644022
    Consensus CDS
    CCDS58869.1
    UniProtKB/Swiss-Prot
    A5X5Y0
    Related
    ENSP00000401900.2, ENST00000425359.6
    Conserved Domains (2) summary
    pfam02931
    Location:55232
    Neur_chan_LBD; Neurotransmitter-gated ion-channel ligand binding domain
    pfam02932
    Location:239338
    Neur_chan_memb; Neurotransmitter-gated ion-channel transmembrane region
  5. NM_198314.2NP_938056.1  5-hydroxytryptamine receptor 3E isoform b

    See identical proteins and their annotated locations for NP_938056.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region, compared to variant 1. This results in a shorter protein (isoform b), compared to isoform a.
    Source sequence(s)
    AC131235, AY159813, AY349353, DQ644022
    Consensus CDS
    CCDS58870.1
    UniProtKB/Swiss-Prot
    A5X5Y0
    Related
    ENSP00000395833.2, ENST00000436361.6
    Conserved Domains (2) summary
    pfam02931
    Location:70247
    Neur_chan_LBD; Neurotransmitter-gated ion-channel ligand binding domain
    pfam02932
    Location:254353
    Neur_chan_memb; Neurotransmitter-gated ion-channel transmembrane region

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210226

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

    Range
    184097064..184106995
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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