U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

ERICH2 glutamate rich 2 [ Homo sapiens (human) ]

Gene ID: 285141, updated on 1-Mar-2024

Summary

Official Symbol
ERICH2provided by HGNC
Official Full Name
glutamate rich 2provided by HGNC
Primary source
HGNC:HGNC:44395
See related
Ensembl:ENSG00000204334 AllianceGenome:HGNC:44395
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Biased expression in testis (RPKM 9.3), thyroid (RPKM 2.2) and 4 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See ERICH2 in Genome Data Viewer
Location:
2q31.1
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (170770378..170798977)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (171247505..171276133)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (171626888..171655487)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene ERICH2 divergent transcript Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:171571431-171572220 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:171572221-171573008 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:171573009-171573798 Neighboring gene Sharpr-MPRA regulatory region 1892 Neighboring gene Sp5 transcription factor Neighboring gene eukaryotic translation initiation factor 2 subunit 2 beta pseudogene 4 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12091 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12092 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12093 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_55930 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:171674788-171675311 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:171675312-171675834 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:171679351-171680150 Neighboring gene glutamate decarboxylase 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16744 Neighboring gene Sharpr-MPRA regulatory region 14 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12094 Neighboring gene golgi reassembly stacking protein 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001289947.2NP_001276876.1  glutamate-rich protein 2 isoform 2

    See identical proteins and their annotated locations for NP_001276876.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, has multiple coding region differences, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (2) has a distinct N-terminus and is shorter than isoform 1.
    Source sequence(s)
    AC007405, BC127676, BQ429225
    Consensus CDS
    CCDS77486.1
    UniProtKB/Swiss-Prot
    A1L162, A7E2T7
    Related
    ENSP00000387298.1, ENST00000409885.1
  2. NM_001290030.2NP_001276959.1  glutamate-rich protein 2 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes isoform 1.
    Source sequence(s)
    AC007405
    Consensus CDS
    CCDS92894.1
    UniProtKB/TrEMBL
    A0A8V8TMA0
    Related
    ENSP00000513252.1, ENST00000697325.1
    Conserved Domains (1) summary
    PHA03247
    Location:34145
    PHA03247; large tegument protein UL36; Provisional
  3. NM_001290031.1NP_001276960.1  glutamate-rich protein 2 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks several exons and its 3' terminal exon extends past a splice site that is used in variant 1. This results in a novel 3' coding region and 3' UTR, compared to variant 1. It encodes isoform 3 which is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC007405, BG215457
    Conserved Domains (1) summary
    PHA03247
    Location:34145
    PHA03247; large tegument protein UL36; Provisional
  4. NM_001388467.1NP_001375396.1  glutamate-rich protein 2 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC007405
    Consensus CDS
    CCDS92895.1
    UniProtKB/TrEMBL
    A0A8V8TMB5
  5. NM_001388468.1NP_001375397.1  glutamate-rich protein 2 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC007405
    Consensus CDS
    CCDS92895.1
    UniProtKB/TrEMBL
    A0A8V8TMB5
  6. NM_001388469.1NP_001375398.1  glutamate-rich protein 2 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC007405
  7. NM_001388470.1NP_001375399.1  glutamate-rich protein 2 isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC007405
  8. NM_001388471.1NP_001375400.1  glutamate-rich protein 2 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC007405
    Conserved Domains (1) summary
    PHA03247
    Location:34145
    PHA03247; large tegument protein UL36; Provisional

RNA

  1. NR_110644.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) contains an alternate 5' exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC007405, BG215457

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    170770378..170798977
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047443999.1XP_047299955.1  glutamate-rich protein 2 isoform X2

  2. XM_017003875.2XP_016859364.1  glutamate-rich protein 2 isoform X1

    UniProtKB/TrEMBL
    A0A8V8TMA0
    Conserved Domains (1) summary
    PHA03247
    Location:34145
    PHA03247; large tegument protein UL36; Provisional
  3. XM_047444000.1XP_047299956.1  glutamate-rich protein 2 isoform X3

    UniProtKB/TrEMBL
    A0A8V8TMB5
    Related
    ENSP00000513268.1, ENST00000697344.1
  4. XM_011511001.3XP_011509303.1  glutamate-rich protein 2 isoform X3

    See identical proteins and their annotated locations for XP_011509303.1

    UniProtKB/TrEMBL
    A0A8V8TMB5

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    171247505..171276133
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054341508.1XP_054197483.1  glutamate-rich protein 2 isoform X1

  2. XM_054341509.1XP_054197484.1  glutamate-rich protein 2 isoform X2

  3. XM_054341510.1XP_054197485.1  glutamate-rich protein 2 isoform X3

    UniProtKB/TrEMBL
    A0A8V8TMB5