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ERICH2 glutamate rich 2 [ Homo sapiens (human) ]

Gene ID: 285141, updated on 7-Jun-2020

Summary

Official Symbol
ERICH2provided by HGNC
Official Full Name
glutamate rich 2provided by HGNC
Primary source
HGNC:HGNC:44395
See related
Ensembl:ENSG00000204334
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Biased expression in testis (RPKM 9.3), thyroid (RPKM 2.2) and 4 other tissues See more
Orthologs

Genomic context

See ERICH2 in Genome Data Viewer
Location:
2q31.1
Exon count:
14
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (170770042..170798977)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (171627528..171655481)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101926913 Neighboring gene Sp5 transcription factor Neighboring gene eukaryotic translation initiation factor 2 subunit 2 beta pseudogene 4 Neighboring gene glutamate decarboxylase 1 Neighboring gene golgi reassembly stacking protein 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Clone Names

  • AC007405.6

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001289947.2NP_001276876.1  glutamate-rich protein 2 isoform 2

    See identical proteins and their annotated locations for NP_001276876.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, has multiple coding region differences, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (2) has a distinct N-terminus and is shorter than isoform 1.
    Source sequence(s)
    AC007405, BC127676, BQ429225
    Consensus CDS
    CCDS77486.1
    UniProtKB/Swiss-Prot
    A1L162
    Related
    ENSP00000387298.1, ENST00000409885.1
  2. NM_001290030.1NP_001276959.1  glutamate-rich protein 2 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes isoform 1.
    Source sequence(s)
    AC007405
    Conserved Domains (1) summary
    PHA03247
    Location:34145
    PHA03247; large tegument protein UL36; Provisional
  3. NM_001290031.1NP_001276960.1  glutamate-rich protein 2 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks several exons and its 3' terminal exon extends past a splice site that is used in variant 1. This results in a novel 3' coding region and 3' UTR, compared to variant 1. It encodes isoform 3 which is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC007405, BG215457
    Conserved Domains (1) summary
    PHA03247
    Location:34145
    PHA03247; large tegument protein UL36; Provisional

RNA

  1. NR_110644.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) contains an alternate 5' exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC007405, BG215457

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    170770042..170798977
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017003875.1XP_016859364.1  glutamate-rich protein 2 isoform X1

    Conserved Domains (1) summary
    PHA03247
    Location:34145
    PHA03247; large tegument protein UL36; Provisional
  2. XM_017003876.2XP_016859365.1  glutamate-rich protein 2 isoform X2

  3. XM_024452812.1XP_024308580.1  glutamate-rich protein 2 isoform X2

  4. XM_011511001.2XP_011509303.1  glutamate-rich protein 2 isoform X2

    See identical proteins and their annotated locations for XP_011509303.1

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