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DLL1 delta like canonical Notch ligand 1 [ Homo sapiens (human) ]

Gene ID: 28514, updated on 13-Mar-2020

Summary

Official Symbol
DLL1provided by HGNC
Official Full Name
delta like canonical Notch ligand 1provided by HGNC
Primary source
HGNC:HGNC:2908
See related
Ensembl:ENSG00000198719 MIM:606582
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DL1; Delta; DELTA1; NEDBAS
Summary
DLL1 is a human homolog of the Notch Delta ligand and is a member of the delta/serrate/jagged family. It plays a role in mediating cell fate decisions during hematopoiesis. It may play a role in cell-to-cell communication. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in spleen (RPKM 12.9), brain (RPKM 6.2) and 22 other tissues See more
Orthologs

Genomic context

See DLL1 in Genome Data Viewer
Location:
6q27
Exon count:
11
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 6 NC_000006.12 (170282200..170291078, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (170591288..170599815, complement)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC154449 Neighboring gene uncharacterized LOC285804 Neighboring gene long intergenic non-protein coding RNA 1624 Neighboring gene translation initiation factor IF-2-like Neighboring gene family with sequence similarity 120B Neighboring gene microRNA 4644

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
NEURODEVELOPMENTAL DISORDER WITH NONSPECIFIC BRAIN ABNORMALITIES AND WITH OR WITHOUT SEIZURES
MedGen: CN263062 OMIM: 618709 GeneReviews: Not available
not available

NHGRI GWAS Catalog

Description
A genome-wide meta-analysis of six type 1 diabetes cohorts identifies multiple associated loci.
NHGRI GWA Catalog
Genetic analysis of the pathogenic molecular sub-phenotype interferon-alpha identifies multiple novel loci involved in systemic lupus erythematosus.
NHGRI GWA Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
Notch binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Notch binding IPI
Inferred from Physical Interaction
more info
PubMed 
Tat protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
calcium ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
scaffold protein binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
Notch signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Notch signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
Notch signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
Notch signaling pathway NAS
Non-traceable Author Statement
more info
PubMed 
Notch signaling pathway involved in arterial endothelial cell fate commitment ISS
Inferred from Sequence or Structural Similarity
more info
 
astrocyte development ISS
Inferred from Sequence or Structural Similarity
more info
 
cell differentiation TAS
Traceable Author Statement
more info
PubMed 
cell fate determination NAS
Non-traceable Author Statement
more info
PubMed 
cerebellar Purkinje cell layer structural organization ISS
Inferred from Sequence or Structural Similarity
more info
 
cerebellar molecular layer formation ISS
Inferred from Sequence or Structural Similarity
more info
 
clathrin-dependent endocytosis ISS
Inferred from Sequence or Structural Similarity
more info
 
compartment pattern specification IEA
Inferred from Electronic Annotation
more info
 
determination of left/right symmetry ISS
Inferred from Sequence or Structural Similarity
more info
 
endothelial tip cell fate specification ISS
Inferred from Sequence or Structural Similarity
more info
 
energy homeostasis ISS
Inferred from Sequence or Structural Similarity
more info
 
heart looping ISS
Inferred from Sequence or Structural Similarity
more info
 
hemopoiesis NAS
Non-traceable Author Statement
more info
PubMed 
inner ear development IEA
Inferred from Electronic Annotation
more info
 
lateral inhibition ISS
Inferred from Sequence or Structural Similarity
more info
 
left/right axis specification IEA
Inferred from Electronic Annotation
more info
 
loop of Henle development IEA
Inferred from Electronic Annotation
more info
 
marginal zone B cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of Notch signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of cardiac muscle cell differentiation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of cell proliferation ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of epidermal cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of epithelial cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of glial cell apoptotic process ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of inner ear auditory receptor cell differentiation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of interleukin-10 production IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of myeloid cell differentiation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of myoblast differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of neuron differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
nephron development ISS
Inferred from Sequence or Structural Similarity
more info
 
neuron fate specification ISS
Inferred from Sequence or Structural Similarity
more info
 
neuronal stem cell population maintenance IEP
Inferred from Expression Pattern
more info
PubMed 
neuronal stem cell population maintenance ISS
Inferred from Sequence or Structural Similarity
more info
 
organ growth ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of Notch signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of cell proliferation ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of endocytosis ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of skeletal muscle tissue growth ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of sprouting angiogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of transcription by RNA polymerase II ISS
Inferred from Sequence or Structural Similarity
more info
 
proximal tubule development IEA
Inferred from Electronic Annotation
more info
 
proximal/distal pattern formation ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of blood pressure ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of cell adhesion TAS
Traceable Author Statement
more info
PubMed 
regulation of cell division ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of growth ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of neurogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of skeletal muscle tissue growth ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of somitogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of vascular endothelial growth factor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
retina development in camera-type eye ISS
Inferred from Sequence or Structural Similarity
more info
 
retina morphogenesis in camera-type eye ISS
Inferred from Sequence or Structural Similarity
more info
 
skeletal muscle tissue growth ISS
Inferred from Sequence or Structural Similarity
more info
 
skin epidermis development ISS
Inferred from Sequence or Structural Similarity
more info
 
somite specification IEA
Inferred from Electronic Annotation
more info
 
somitogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
spinal cord development ISS
Inferred from Sequence or Structural Similarity
more info
 
type B pancreatic cell development ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
adherens junction ISS
Inferred from Sequence or Structural Similarity
more info
 
apical plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
 
extracellular region NAS
Non-traceable Author Statement
more info
PubMed 
integral component of plasma membrane NAS
Non-traceable Author Statement
more info
PubMed 
membrane raft ISS
Inferred from Sequence or Structural Similarity
more info
 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
delta-like protein 1
Names
H-Delta-1
drosophila Delta homolog 1
epididymis secretory sperm binding protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_027940.1 RefSeqGene

    Range
    4532..13404
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_005618.4NP_005609.3  delta-like protein 1 precursor

    See identical proteins and their annotated locations for NP_005609.3

    Status: REVIEWED

    Source sequence(s)
    AL078605, AY358892, DA243552, DR000029
    Consensus CDS
    CCDS5313.1
    UniProtKB/Swiss-Prot
    O00548
    Related
    ENSP00000355718.3, ENST00000366756.4
    Conserved Domains (3) summary
    smart00051
    Location:159221
    DSL; delta serrate ligand
    cd00054
    Location:329364
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    pfam07657
    Location:2292
    MNNL; N terminus of Notch ligand

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p13 Primary Assembly

    Range
    170282200..170291078 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005266934.4XP_005266991.1  delta-like protein 1 isoform X1

    See identical proteins and their annotated locations for XP_005266991.1

    Conserved Domains (3) summary
    cd00054
    Location:329364
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    pfam01414
    Location:159221
    DSL; Delta serrate ligand
    pfam07657
    Location:2291
    MNNL; N terminus of Notch ligand

Reference GRCh38.p13 ALT_REF_LOCI_1

Genomic

  1. NT_187553.1 Reference GRCh38.p13 ALT_REF_LOCI_1

    Range
    9444..18316 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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