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DNAJC5G DnaJ heat shock protein family (Hsp40) member C5 gamma [ Homo sapiens (human) ]

Gene ID: 285126, updated on 23-Nov-2021

Summary

Official Symbol
DNAJC5Gprovided by HGNC
Official Full Name
DnaJ heat shock protein family (Hsp40) member C5 gammaprovided by HGNC
Primary source
HGNC:HGNC:24844
See related
Ensembl:ENSG00000163793 MIM:613946
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CSP-gamma
Expression
Restricted expression toward testis (RPKM 12.4) See more
Orthologs
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Genomic context

See DNAJC5G in Genome Data Viewer
Location:
2p23.3
Exon count:
7
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (27275427..27281499)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (27498301..27504367)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene solute carrier family 5 member 6 Neighboring gene all-trans retinoic acid induced differentiation factor Neighboring gene carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase Neighboring gene solute carrier family 30 member 3 Neighboring gene tripartite motif containing 54 Neighboring gene Sharpr-MPRA regulatory regions 9483 and 12628 Neighboring gene mitochondrial inner membrane protein MPV17 Neighboring gene urocortin

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ40417

Gene Ontology Provided by GOA

Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
dnaJ homolog subfamily C member 5G
Names
DnaJ (Hsp40) homolog, subfamily C, member 5 gamma
cysteine string protein-gamma
gamma-CSP
gamma-cysteine string protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001303127.2NP_001290056.1  dnaJ homolog subfamily C member 5G isoform 1

    See identical proteins and their annotated locations for NP_001290056.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same isoform (1).
    Source sequence(s)
    AC013413, AK097736, BC035194
    Consensus CDS
    CCDS1744.1
    UniProtKB/Swiss-Prot
    Q8N7S2
    Related
    ENSP00000384305.1, ENST00000402462.5
    Conserved Domains (2) summary
    COG0484
    Location:1398
    DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]
    pfam00226
    Location:1795
    DnaJ; DnaJ domain
  2. NM_001303128.2NP_001290057.1  dnaJ homolog subfamily C member 5G isoform 2

    See identical proteins and their annotated locations for NP_001290057.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an internal exon which results in a frameshift, compared to variant 1. The encoded isoform (2) has a distinct and shorter C-terminus, compared to isoform 1.
    Source sequence(s)
    AC013413, AK097736, AK302239, BC035194
    Consensus CDS
    CCDS77397.1
    UniProtKB/Swiss-Prot
    Q8N7S2
    Related
    ENSP00000385533.1, ENST00000406962.1
    Conserved Domains (1) summary
    cl02542
    Location:1741
    DnaJ; DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s, ...
  3. NM_173650.3NP_775921.1  dnaJ homolog subfamily C member 5G isoform 1

    See identical proteins and their annotated locations for NP_775921.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC013413, AF368277, AI183575, AK097736, BC035194
    Consensus CDS
    CCDS1744.1
    UniProtKB/Swiss-Prot
    Q8N7S2
    Related
    ENSP00000296097.3, ENST00000296097.8
    Conserved Domains (2) summary
    COG0484
    Location:1398
    DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]
    pfam00226
    Location:1795
    DnaJ; DnaJ domain

RNA

  1. NR_130126.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks two internal exons compared to variant 1. This variant is represented as non-coding because the predicted protein does not meet RefSeq quality criteria.
    Source sequence(s)
    AC013413, AK097736, BC035194, DB454465

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    27275427..27281499
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017003872.2XP_016859361.1  dnaJ homolog subfamily C member 5G isoform X1

    UniProtKB/Swiss-Prot
    Q8N7S2
    Conserved Domains (2) summary
    COG0484
    Location:1398
    DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]
    pfam00226
    Location:1795
    DnaJ; DnaJ domain
  2. XM_017003873.2XP_016859362.1  dnaJ homolog subfamily C member 5G isoform X1

    UniProtKB/Swiss-Prot
    Q8N7S2
    Conserved Domains (2) summary
    COG0484
    Location:1398
    DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]
    pfam00226
    Location:1795
    DnaJ; DnaJ domain
  3. XM_017003874.2XP_016859363.1  dnaJ homolog subfamily C member 5G isoform X1

    UniProtKB/Swiss-Prot
    Q8N7S2
    Related
    ENSP00000385829.1, ENST00000404433.5
    Conserved Domains (2) summary
    COG0484
    Location:1398
    DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]
    pfam00226
    Location:1795
    DnaJ; DnaJ domain
  4. XM_006711995.3XP_006712058.1  dnaJ homolog subfamily C member 5G isoform X1

    See identical proteins and their annotated locations for XP_006712058.1

    UniProtKB/Swiss-Prot
    Q8N7S2
    Conserved Domains (2) summary
    COG0484
    Location:1398
    DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]
    pfam00226
    Location:1795
    DnaJ; DnaJ domain
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