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GPR27 G protein-coupled receptor 27 [ Homo sapiens (human) ]

Gene ID: 2850, updated on 13-Mar-2020

Summary

Official Symbol
GPR27provided by HGNC
Official Full Name
G protein-coupled receptor 27provided by HGNC
Primary source
HGNC:HGNC:4482
See related
Ensembl:ENSG00000170837 MIM:605187
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SREB1
Summary
GPR27 is a member of the G protein-coupled receptors (GPCRs), a large family of receptors that have a similar structure characterized by 7 transmembrane domains. Activation of GPCRs by extracellular stimuli such as neurotransmitters, hormones, or light induces an intracellular signaling cascade mediated by heterotrimeric GTP-binding proteins, or G proteins.[supplied by OMIM, May 2010]
Orthologs

Genomic context

See GPR27 in Genome Data Viewer
Location:
3p13
Exon count:
1
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (71753855..71756496)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (71803201..71804328)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene forkhead box P1 Neighboring gene microRNA 1284 Neighboring gene uncharacterized LOC105377155 Neighboring gene eukaryotic translation initiation factor 4E family member 3 Neighboring gene uncharacterized LOC105377156 Neighboring gene prokineticin 2

Genomic regions, transcripts, and products

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
G protein-coupled receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
probable G-protein coupled receptor 27
Names
super conserved receptor expressed in brain 1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_018971.3NP_061844.1  probable G-protein coupled receptor 27

    See identical proteins and their annotated locations for NP_061844.1

    Status: VALIDATED

    Source sequence(s)
    AC096970
    Consensus CDS
    CCDS2915.1
    UniProtKB/Swiss-Prot
    Q9NS67
    UniProtKB/TrEMBL
    F1DAM3
    Related
    ENSP00000303149.2, ENST00000304411.3
    Conserved Domains (1) summary
    cd15216
    Location:19349
    7tmA_SREB1_GPR27; super conserved receptor expressed in brain 1 (or GPR27), member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

    Range
    71753855..71756496
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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