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ANGPT2 angiopoietin 2 [ Homo sapiens (human) ]

Gene ID: 285, updated on 19-Sep-2021

Summary

Official Symbol
ANGPT2provided by HGNC
Official Full Name
angiopoietin 2provided by HGNC
Primary source
HGNC:HGNC:485
See related
Ensembl:ENSG00000091879 MIM:601922
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ANG2; AGPT2; LMPHM10
Summary
This gene belongs to the angiopoietin family of growth factors. The protein encoded by this gene is an antagonist of angiopoietin 1, and both angiopoietin 1 and angiopoietin 2 are ligands for the endothelial TEK receptor tyrosine kinase. Angiopoietin 2 is upregulated in multiple inflammatory diseases and is implicated in the direct control of inflammation-related signaling pathways. The encoded protein affects angiogenesis during embryogenesis and tumorigenesis, disrupts the vascular remodeling ability of angiopoietin 1, and may induce endothelial cell apoptosis. This gene serves a prognostic biomarker for acute respiratory distress syndrome. [provided by RefSeq, Aug 2020]
Expression
Broad expression in placenta (RPKM 6.2), urinary bladder (RPKM 5.1) and 19 other tissues See more
Orthologs
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Genomic context

See ANGPT2 in Genome Data Viewer
Location:
8p23.1
Exon count:
9
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 8 NC_000008.11 (6499632..6563245, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (6357153..6420766, complement)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene MCPH1 divergent transcript Neighboring gene microcephalin 1 Neighboring gene adenylate kinase isoenzyme 6 pseudogene Neighboring gene MCPH1 antisense RNA 1 Neighboring gene microRNA 8055 Neighboring gene protein tyrosine phosphatase non-receptor type 4 pseudogene Neighboring gene 1-acylglycerol-3-phosphate O-acyltransferase 5

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Discovery of genetic biomarkers contributing to variation in drug response of cytidine analogues using human lymphoblastoid cell lines.
GeneReviews: Not available
LYMPHATIC MALFORMATION 10
MedGen: CN296940 OMIM: 619369 GeneReviews: Not available
not available

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables receptor tyrosine kinase binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables receptor tyrosine kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables signaling receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in Tie signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in Tie signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in angiogenesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in animal organ regeneration IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to growth factor stimulus IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within gene expression IDA
Inferred from Direct Assay
more info
PubMed 
involved_in germ cell development IEA
Inferred from Electronic Annotation
more info
 
involved_in glomerulus vasculature development ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in maternal process involved in female pregnancy IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of angiogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of blood vessel endothelial cell migration IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of cell-substrate adhesion IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of positive chemotaxis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of angiogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in response to activity IEA
Inferred from Electronic Annotation
more info
 
involved_in response to glucose IEA
Inferred from Electronic Annotation
more info
 
involved_in response to hypoxia IEA
Inferred from Electronic Annotation
more info
 
involved_in response to mechanical stimulus IEA
Inferred from Electronic Annotation
more info
 
involved_in response to organic cyclic compound IEA
Inferred from Electronic Annotation
more info
 
involved_in response to radiation IEA
Inferred from Electronic Annotation
more info
 
involved_in signal transduction TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
located_in cell projection IEA
Inferred from Electronic Annotation
more info
 
is_active_in collagen-containing extracellular matrix IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in extracellular region TAS
Traceable Author Statement
more info
 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
angiopoietin-2
Names
Tie2-ligand
angiopoietin-2B
angiopoietin-2a

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029483.1 RefSeqGene

    Range
    5019..68632
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001118887.2NP_001112359.1  angiopoietin-2 isoform b precursor

    See identical proteins and their annotated locations for NP_001112359.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site compared to variant 1, resulting in an isoform (b) that lacks an internal aa compared to isoform a.
    Source sequence(s)
    AC018398, BC022490, BC126200, DA829327
    Consensus CDS
    CCDS47762.1
    UniProtKB/Swiss-Prot
    O15123
    Related
    ENSP00000486858.2, ENST00000629816.3
    Conserved Domains (2) summary
    smart00186
    Location:279493
    FBG; Fibrinogen-related domains (FReDs)
    cl19219
    Location:138243
    DUF342; Protein of unknown function (DUF342)
  2. NM_001118888.2NP_001112360.1  angiopoietin-2 isoform c precursor

    See identical proteins and their annotated locations for NP_001112360.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an alternate in-frame exon compared to variant 1, resulting in an isoform (c) that has the same N- and C-termini but is shorter compared to isoform a.
    Source sequence(s)
    AC018398, AF187858, AK290070, DA829327
    Consensus CDS
    CCDS47761.1
    UniProtKB/Swiss-Prot
    O15123
    Related
    ENSP00000343517.6, ENST00000338312.10
    Conserved Domains (2) summary
    smart00186
    Location:228442
    FBG; Fibrinogen-related domains (FReDs)
    cl19252
    Location:122187
    MreC; rod shape-determining protein MreC
  3. NM_001147.3NP_001138.1  angiopoietin-2 isoform a precursor

    See identical proteins and their annotated locations for NP_001138.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
    Source sequence(s)
    AC018398, AK290070, BC126200, DA829327
    Consensus CDS
    CCDS5958.1
    UniProtKB/Swiss-Prot
    O15123
    Related
    ENSP00000314897.5, ENST00000325203.9
    Conserved Domains (2) summary
    smart00186
    Location:280494
    FBG; Fibrinogen-related domains (FReDs)
    cl25732
    Location:78295
    SMC_N; RecF/RecN/SMC N terminal domain
  4. NM_001386335.1NP_001373264.1  angiopoietin-2 isoform d precursor

    Status: REVIEWED

    Source sequence(s)
    AC018398
    Conserved Domains (2) summary
    smart00186
    Location:227441
    FBG; Fibrinogen-related domains (FReDs)
    pfam15921
    Location:46242
    CCDC158; Coiled-coil domain-containing protein 158
  5. NM_001386336.1NP_001373265.1  angiopoietin-2 isoform e precursor

    Status: REVIEWED

    Source sequence(s)
    AC018398
    Conserved Domains (2) summary
    smart00186
    Location:280403
    FBG; Fibrinogen-related domains (FReDs)
    pfam15921
    Location:78295
    CCDC158; Coiled-coil domain-containing protein 158
  6. NM_001386337.1NP_001373266.1  angiopoietin-2 isoform f precursor

    Status: REVIEWED

    Source sequence(s)
    AC018398
    Conserved Domains (2) summary
    smart00186
    Location:279402
    FBG; Fibrinogen-related domains (FReDs)
    pfam15921
    Location:78294
    CCDC158; Coiled-coil domain-containing protein 158

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p13 Primary Assembly

    Range
    6499632..6563245 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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