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NT5DC4 5'-nucleotidase domain containing 4 [ Homo sapiens (human) ]

Gene ID: 284958, updated on 4-Nov-2022

Summary

Official Symbol
NT5DC4provided by HGNC
Official Full Name
5'-nucleotidase domain containing 4provided by HGNC
Primary source
HGNC:HGNC:27678
See related
Ensembl:ENSG00000144130 AllianceGenome:HGNC:27678
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable 5'-nucleotidase activity. Predicted to be involved in dephosphorylation. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in testis (RPKM 1.0), lymph node (RPKM 0.3) and 3 other tissues See more
Orthologs
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Genomic context

See NT5DC4 in Genome Data Viewer
Location:
2q14.1
Exon count:
25
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (112718876..112742879)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (113147621..113169534)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (113478597..113500456)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 7980 Neighboring gene solute carrier family 20 member 1 Neighboring gene uncharacterized LOC102724955 Neighboring gene cytoskeleton associated protein 2 like Neighboring gene Sharpr-MPRA regulatory region 10892 Neighboring gene interleukin 1 alpha

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables 5'-nucleotidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
5'-nucleotidase domain-containing protein 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001350494.2NP_001337423.1  5'-nucleotidase domain-containing protein 4 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC079922, BC041437
    Consensus CDS
    CCDS86877.1
    Related
    ENSP00000330247.4, ENST00000327581.4
    Conserved Domains (1) summary
    pfam05761
    Location:13390
    5_nucleotid; 5' nucleotidase family
  2. NM_001393655.1NP_001380584.1  5'-nucleotidase domain-containing protein 4 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AC079922
    Consensus CDS
    CCDS92846.1
    UniProtKB/TrEMBL
    A0A8I5KS70
    Related
    ENSP00000509504.1, ENST00000688554.1
    Conserved Domains (1) summary
    cd07522
    Location:27373
    HAD_cN-II; cytosolic 5'-nucleotidase II (cN-II) similar to human NT5DC1 (5'-nucleotidase domain-containing protein 1) and NT5DC2

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    112718876..112742879
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017005477.2XP_016860966.1  5'-nucleotidase domain-containing protein 4 isoform X13

  2. XM_017005476.2XP_016860965.1  5'-nucleotidase domain-containing protein 4 isoform X12

    UniProtKB/TrEMBL
    A0A8I5KQQ4
    Related
    ENSP00000508583.1, ENST00000690591.1
  3. XM_017005478.2XP_016860967.1  5'-nucleotidase domain-containing protein 4 isoform X15

    UniProtKB/TrEMBL
    A0A8I5KQP2
    Related
    ENSP00000509747.1, ENST00000689550.1
  4. XM_024452802.2XP_024308570.1  5'-nucleotidase domain-containing protein 4 isoform X5

    Conserved Domains (1) summary
    pfam05761
    Location:103491
    5_nucleotid; 5' nucleotidase family
  5. XM_017005475.1XP_016860964.1  5'-nucleotidase domain-containing protein 4 isoform X9

  6. XM_024452799.2XP_024308567.1  5'-nucleotidase domain-containing protein 4 isoform X1

    Conserved Domains (1) summary
    pfam05761
    Location:103491
    5_nucleotid; 5' nucleotidase family
  7. XM_024452807.2XP_024308575.1  5'-nucleotidase domain-containing protein 4 isoform X11

    Conserved Domains (1) summary
    cl17687
    Location:103434
    5_nucleotid; 5' nucleotidase family
  8. XM_024452800.2XP_024308568.1  5'-nucleotidase domain-containing protein 4 isoform X3

    Conserved Domains (1) summary
    pfam05761
    Location:103485
    5_nucleotid; 5' nucleotidase family
  9. XM_024452803.2XP_024308571.1  5'-nucleotidase domain-containing protein 4 isoform X6

    Conserved Domains (1) summary
    cl17687
    Location:103449
    5_nucleotid; 5' nucleotidase family
  10. XM_024452808.2XP_024308576.1  5'-nucleotidase domain-containing protein 4 isoform X14

    Conserved Domains (1) summary
    cl17687
    Location:103392
    5_nucleotid; 5' nucleotidase family
  11. XM_011512262.3XP_011510564.1  5'-nucleotidase domain-containing protein 4 isoform X2

    Conserved Domains (1) summary
    pfam05761
    Location:103486
    5_nucleotid; 5' nucleotidase family
  12. XM_017005474.2XP_016860963.1  5'-nucleotidase domain-containing protein 4 isoform X4

    Conserved Domains (1) summary
    cd07522
    Location:96431
    HAD_cN-II; cytosolic 5'-nucleotidase II (cN-II) similar to human NT5DC1 (5'-nucleotidase domain-containing protein 1) and NT5DC2
  13. XM_024452804.2XP_024308572.1  5'-nucleotidase domain-containing protein 4 isoform X7

    Conserved Domains (1) summary
    pfam05761
    Location:103491
    5_nucleotid; 5' nucleotidase family
  14. XM_024452805.2XP_024308573.1  5'-nucleotidase domain-containing protein 4 isoform X8

    Conserved Domains (1) summary
    pfam05761
    Location:103491
    5_nucleotid; 5' nucleotidase family
  15. XM_024452806.2XP_024308574.1  5'-nucleotidase domain-containing protein 4 isoform X10

    Conserved Domains (1) summary
    pfam05761
    Location:103491
    5_nucleotid; 5' nucleotidase family
  16. XM_047443973.1XP_047299929.1  5'-nucleotidase domain-containing protein 4 isoform X16

  17. XM_047443974.1XP_047299930.1  5'-nucleotidase domain-containing protein 4 isoform X20

  18. XM_024452809.1XP_024308577.1  5'-nucleotidase domain-containing protein 4 isoform X18

    Conserved Domains (1) summary
    cl17687
    Location:103333
    5_nucleotid; 5' nucleotidase family
  19. XM_024452810.1XP_024308578.1  5'-nucleotidase domain-containing protein 4 isoform X19

    Conserved Domains (1) summary
    cl17687
    Location:103328
    5_nucleotid; 5' nucleotidase family
  20. XM_011512265.3XP_011510567.1  5'-nucleotidase domain-containing protein 4 isoform X17

    Conserved Domains (1) summary
    cl17687
    Location:15279
    5_nucleotid; 5' nucleotidase family

RNA

  1. XR_002959269.2 RNA Sequence

  2. XR_002959270.1 RNA Sequence

  3. XR_002959268.2 RNA Sequence

  4. XR_002959267.2 RNA Sequence

  5. XR_001739644.2 RNA Sequence

  6. XR_002959275.1 RNA Sequence

  7. XR_002959274.1 RNA Sequence

  8. XR_002959272.1 RNA Sequence

  9. XR_002959273.1 RNA Sequence

  10. XR_002959276.1 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    113147621..113169534
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)