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SH2D6 SH2 domain containing 6 [ Homo sapiens (human) ]

Gene ID: 284948, updated on 17-Jun-2024

Summary

Official Symbol
SH2D6provided by HGNC
Official Full Name
SH2 domain containing 6provided by HGNC
Primary source
HGNC:HGNC:30439
See related
Ensembl:ENSG00000152292 AllianceGenome:HGNC:30439
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SLNK
Summary
Predicted to be involved in intracellular signal transduction and transmembrane receptor protein tyrosine kinase signaling pathway. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in testis (RPKM 1.1), duodenum (RPKM 0.9) and 9 other tissues See more
Orthologs
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Genomic context

See SH2D6 in Genome Data Viewer
Location:
2p11.2
Exon count:
25
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (85418714..85437029)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (85420731..85439046)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (85645837..85664152)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene ELMO domain containing 3 Neighboring gene U7 small nuclear RNA Neighboring gene capping actin protein, gelsolin like Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:85628953-85629452 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16122 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11696 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11697 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:85640593-85641094 Neighboring gene uncharacterized LOC105374841 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11698 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16124 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:85645284-85645819 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16126 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:85658733-85659404 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:85659405-85660075 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:85660076-85660746 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11699 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11700 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:85665369-85665885 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:85665886-85666401 Neighboring gene RNA, 7SL, cytoplasmic 251, pseudogene Neighboring gene RNA, U7 small nuclear 64 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

General gene information

Markers

Clone Names

  • FLJ35993

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in cell surface receptor protein tyrosine kinase signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
SH2 domain-containing protein 6
Names
SH2 linker protein related to BLNK

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001394463.1NP_001381392.1  SH2 domain-containing protein 6

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the protein-coding transcript.
    Source sequence(s)
    AC016753, AC062037
    Consensus CDS
    CCDS92791.1
    UniProtKB/Swiss-Prot
    A0A8I5KXG6, A6ND14, Q6R306, Q7Z4S9
    UniProtKB/TrEMBL
    A0A494C0E1
    Related
    ENSP00000510308.1, ENST00000469800.7
    Conserved Domains (2) summary
    cd09929
    Location:213334
    SH2_BLNK_SLP-76; Src homology 2 (SH2) domain found in B-cell linker (BLNK) protein and SH2 domain-containing leukocyte protein of 76 kDa (SLP-76)
    cl41773
    Location:91211
    SP1-4_N; N-terminal domain of transcription factor Specificity Proteins (SP) 1-4

RNA

  1. NR_172131.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC016753, AC062037
    Related
    ENST00000389938.7

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    85418714..85437029
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017003839.1XP_016859328.1  SH2 domain-containing protein 6 isoform X1

    Conserved Domains (1) summary
    cd09929
    Location:223344
    SH2_BLNK_SLP-76; Src homology 2 (SH2) domain found in B-cell linker (BLNK) protein and SH2 domain-containing leukocyte protein of 76 kDa (SLP-76)
  2. XM_017003841.2XP_016859330.1  SH2 domain-containing protein 6 isoform X3

    Conserved Domains (1) summary
    cl15255
    Location:223312
    SH2; Src homology 2 (SH2) domain
  3. XM_017003857.2XP_016859346.1  SH2 domain-containing protein 6 isoform X16

  4. XM_047443972.1XP_047299928.1  SH2 domain-containing protein 6 isoform X15

  5. XM_017003856.2XP_016859345.1  SH2 domain-containing protein 6 isoform X16

  6. XM_017003853.2XP_016859342.1  SH2 domain-containing protein 6 isoform X14

  7. XM_017003854.2XP_016859343.1  SH2 domain-containing protein 6 isoform X14

  8. XM_047443971.1XP_047299927.1  SH2 domain-containing protein 6 isoform X7

  9. XM_047443969.1XP_047299925.1  SH2 domain-containing protein 6 isoform X1

  10. XM_017003847.2XP_016859336.1  SH2 domain-containing protein 6 isoform X9

    Conserved Domains (1) summary
    cl15255
    Location:227316
    SH2; Src homology 2 (SH2) domain
  11. XM_017003848.2XP_016859337.1  SH2 domain-containing protein 6 isoform X10

    Conserved Domains (1) summary
    cl15255
    Location:226315
    SH2; Src homology 2 (SH2) domain
  12. XM_017003849.2XP_016859338.1  SH2 domain-containing protein 6 isoform X11

    Conserved Domains (1) summary
    cd09929
    Location:190311
    SH2_BLNK_SLP-76; Src homology 2 (SH2) domain found in B-cell linker (BLNK) protein and SH2 domain-containing leukocyte protein of 76 kDa (SLP-76)
  13. XM_017003840.2XP_016859329.1  SH2 domain-containing protein 6 isoform X2

    Conserved Domains (1) summary
    cd09929
    Location:222343
    SH2_BLNK_SLP-76; Src homology 2 (SH2) domain found in B-cell linker (BLNK) protein and SH2 domain-containing leukocyte protein of 76 kDa (SLP-76)
  14. XM_017003851.2XP_016859340.1  SH2 domain-containing protein 6 isoform X13

    Conserved Domains (1) summary
    cd09929
    Location:126247
    SH2_BLNK_SLP-76; Src homology 2 (SH2) domain found in B-cell linker (BLNK) protein and SH2 domain-containing leukocyte protein of 76 kDa (SLP-76)
  15. XM_017003843.2XP_016859332.1  SH2 domain-containing protein 6 isoform X6

    Conserved Domains (1) summary
    cd09929
    Location:205326
    SH2_BLNK_SLP-76; Src homology 2 (SH2) domain found in B-cell linker (BLNK) protein and SH2 domain-containing leukocyte protein of 76 kDa (SLP-76)
  16. XM_017003850.2XP_016859339.1  SH2 domain-containing protein 6 isoform X12

  17. XM_017003837.2XP_016859326.1  SH2 domain-containing protein 6 isoform X1

    Conserved Domains (1) summary
    cd09929
    Location:223344
    SH2_BLNK_SLP-76; Src homology 2 (SH2) domain found in B-cell linker (BLNK) protein and SH2 domain-containing leukocyte protein of 76 kDa (SLP-76)
  18. XM_017003845.2XP_016859334.1  SH2 domain-containing protein 6 isoform X6

    Conserved Domains (1) summary
    cd09929
    Location:205326
    SH2_BLNK_SLP-76; Src homology 2 (SH2) domain found in B-cell linker (BLNK) protein and SH2 domain-containing leukocyte protein of 76 kDa (SLP-76)
  19. XM_017003835.2XP_016859324.1  SH2 domain-containing protein 6 isoform X1

    Conserved Domains (1) summary
    cd09929
    Location:223344
    SH2_BLNK_SLP-76; Src homology 2 (SH2) domain found in B-cell linker (BLNK) protein and SH2 domain-containing leukocyte protein of 76 kDa (SLP-76)
  20. XM_017003844.2XP_016859333.1  SH2 domain-containing protein 6 isoform X6

    Conserved Domains (1) summary
    cd09929
    Location:205326
    SH2_BLNK_SLP-76; Src homology 2 (SH2) domain found in B-cell linker (BLNK) protein and SH2 domain-containing leukocyte protein of 76 kDa (SLP-76)
  21. XM_017003842.2XP_016859331.1  SH2 domain-containing protein 6 isoform X4

    UniProtKB/Swiss-Prot
    A0A8I5KXG6, A6ND14, Q6R306, Q7Z4S9
    UniProtKB/TrEMBL
    A0A494C0E1
    Related
    ENSP00000498488.1, ENST00000651736.1
    Conserved Domains (2) summary
    cd09929
    Location:213334
    SH2_BLNK_SLP-76; Src homology 2 (SH2) domain found in B-cell linker (BLNK) protein and SH2 domain-containing leukocyte protein of 76 kDa (SLP-76)
    cl41773
    Location:91211
    SP1-4_N; N-terminal domain of transcription factor Specificity Proteins (SP) 1-4
  22. XM_017003846.2XP_016859335.1  SH2 domain-containing protein 6 isoform X8

    UniProtKB/TrEMBL
    A0A494C0E1
    Conserved Domains (1) summary
    cd09929
    Location:195316
    SH2_BLNK_SLP-76; Src homology 2 (SH2) domain found in B-cell linker (BLNK) protein and SH2 domain-containing leukocyte protein of 76 kDa (SLP-76)
  23. XM_011532783.1XP_011531085.1  SH2 domain-containing protein 6 isoform X5

    See identical proteins and their annotated locations for XP_011531085.1

    Conserved Domains (1) summary
    cd09929
    Location:212333
    SH2_BLNK_SLP-76; Src homology 2 (SH2) domain found in B-cell linker (BLNK) protein and SH2 domain-containing leukocyte protein of 76 kDa (SLP-76)
  24. XM_017003860.2XP_016859349.1  SH2 domain-containing protein 6 isoform X17

    UniProtKB/TrEMBL
    B3KSC4
    Conserved Domains (1) summary
    cd09929
    Location:49170
    SH2_BLNK_SLP-76; Src homology 2 (SH2) domain found in B-cell linker (BLNK) protein and SH2 domain-containing leukocyte protein of 76 kDa (SLP-76)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    85420731..85439046
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054341424.1XP_054197399.1  SH2 domain-containing protein 6 isoform X1

  2. XM_054341427.1XP_054197402.1  SH2 domain-containing protein 6 isoform X3

  3. XM_054341444.1XP_054197419.1  SH2 domain-containing protein 6 isoform X16

  4. XM_054341442.1XP_054197417.1  SH2 domain-containing protein 6 isoform X15

  5. XM_054341443.1XP_054197418.1  SH2 domain-containing protein 6 isoform X16

  6. XM_054341440.1XP_054197415.1  SH2 domain-containing protein 6 isoform X14

  7. XM_054341441.1XP_054197416.1  SH2 domain-containing protein 6 isoform X14

  8. XM_054341433.1XP_054197408.1  SH2 domain-containing protein 6 isoform X7

  9. XM_054341422.1XP_054197397.1  SH2 domain-containing protein 6 isoform X1

  10. XM_054341435.1XP_054197410.1  SH2 domain-containing protein 6 isoform X9

  11. XM_054341436.1XP_054197411.1  SH2 domain-containing protein 6 isoform X10

  12. XM_054341437.1XP_054197412.1  SH2 domain-containing protein 6 isoform X11

  13. XM_054341426.1XP_054197401.1  SH2 domain-containing protein 6 isoform X2

  14. XM_054341439.1XP_054197414.1  SH2 domain-containing protein 6 isoform X13

  15. XM_054341430.1XP_054197405.1  SH2 domain-containing protein 6 isoform X6

  16. XM_054341438.1XP_054197413.1  SH2 domain-containing protein 6 isoform X12

  17. XM_054341425.1XP_054197400.1  SH2 domain-containing protein 6 isoform X1

  18. XM_054341432.1XP_054197407.1  SH2 domain-containing protein 6 isoform X6

  19. XM_054341423.1XP_054197398.1  SH2 domain-containing protein 6 isoform X1

  20. XM_054341431.1XP_054197406.1  SH2 domain-containing protein 6 isoform X6

  21. XM_054341428.1XP_054197403.1  SH2 domain-containing protein 6 isoform X4

    UniProtKB/Swiss-Prot
    A0A8I5KXG6, A6ND14, Q6R306, Q7Z4S9
    UniProtKB/TrEMBL
    A0A494C0E1
  22. XM_054341434.1XP_054197409.1  SH2 domain-containing protein 6 isoform X8

    UniProtKB/TrEMBL
    A0A494C0E1
  23. XM_054341429.1XP_054197404.1  SH2 domain-containing protein 6 isoform X5

  24. XM_054341445.1XP_054197420.1  SH2 domain-containing protein 6 isoform X17

    UniProtKB/TrEMBL
    B3KSC4

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_198482.1: Suppressed sequence

    Description
    NM_198482.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.