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SH2D6 SH2 domain containing 6 [ Homo sapiens (human) ]

Gene ID: 284948, updated on 23-Nov-2021

Summary

Official Symbol
SH2D6provided by HGNC
Official Full Name
SH2 domain containing 6provided by HGNC
Primary source
HGNC:HGNC:30439
See related
Ensembl:ENSG00000152292
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Biased expression in testis (RPKM 1.1), duodenum (RPKM 0.9) and 9 other tissues See more
Orthologs
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Genomic context

See SH2D6 in Genome Data Viewer
Location:
2p11.2
Exon count:
26
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (85418714..85437029)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (85646054..85664152)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene ELMO domain containing 3 Neighboring gene RNA, 7SL, cytoplasmic 113, pseudogene Neighboring gene capping actin protein, gelsolin like Neighboring gene uncharacterized LOC105374841 Neighboring gene RNA, 7SL, cytoplasmic 251, pseudogene Neighboring gene RNA, U7 small nuclear 64 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Phenotypes

Associated conditions

Description Tests
A genome-wide association study identifies protein quantitative trait loci (pQTLs).
GeneReviews: Not available

General gene information

Markers

Homology

Clone Names

  • FLJ35993

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in transmembrane receptor protein tyrosine kinase signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
SH2 domain-containing protein 6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001394463.1NP_001381392.1  SH2 domain-containing protein 6

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the protein-coding transcript.
    Source sequence(s)
    AC016753, AC062037
    Conserved Domains (2) summary
    cd09929
    Location:213334
    SH2_BLNK_SLP-76; Src homology 2 (SH2) domain found in B-cell linker (BLNK) protein and SH2 domain-containing leukocyte protein of 76 kDa (SLP-76)
    cl41773
    Location:91211
    SP1-4_N; N-terminal domain of transcription factor Specificity Proteins (SP) 1-4

RNA

  1. NR_172131.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC016753, AC062037

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    85418714..85437029
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017003858.1XP_016859347.1  SH2 domain-containing protein 6 isoform X16

    UniProtKB/Swiss-Prot
    Q7Z4S9
    Conserved Domains (1) summary
    cl15255
    Location:53142
    SH2; Src homology 2 (SH2) domain
  2. XM_017003838.1XP_016859327.1  SH2 domain-containing protein 6 isoform X1

    Conserved Domains (1) summary
    cd09929
    Location:223344
    SH2_BLNK_SLP-76; Src homology 2 (SH2) domain found in B-cell linker (BLNK) protein and SH2 domain-containing leukocyte protein of 76 kDa (SLP-76)
  3. XM_017003841.1XP_016859330.1  SH2 domain-containing protein 6 isoform X3

    Conserved Domains (1) summary
    cl15255
    Location:223312
    SH2; Src homology 2 (SH2) domain
  4. XM_017003857.1XP_016859346.1  SH2 domain-containing protein 6 isoform X14

  5. XM_017003856.1XP_016859345.1  SH2 domain-containing protein 6 isoform X14

  6. XM_017003853.1XP_016859342.1  SH2 domain-containing protein 6 isoform X13

  7. XM_017003855.1XP_016859344.1  SH2 domain-containing protein 6 isoform X13

  8. XM_017003854.1XP_016859343.1  SH2 domain-containing protein 6 isoform X13

  9. XM_017003836.1XP_016859325.1  SH2 domain-containing protein 6 isoform X1

    Conserved Domains (1) summary
    cd09929
    Location:223344
    SH2_BLNK_SLP-76; Src homology 2 (SH2) domain found in B-cell linker (BLNK) protein and SH2 domain-containing leukocyte protein of 76 kDa (SLP-76)
  10. XM_017003839.1XP_016859328.1  SH2 domain-containing protein 6 isoform X1

    Conserved Domains (1) summary
    cd09929
    Location:223344
    SH2_BLNK_SLP-76; Src homology 2 (SH2) domain found in B-cell linker (BLNK) protein and SH2 domain-containing leukocyte protein of 76 kDa (SLP-76)
  11. XM_017003848.1XP_016859337.1  SH2 domain-containing protein 6 isoform X9

    Conserved Domains (1) summary
    cl15255
    Location:226315
    SH2; Src homology 2 (SH2) domain
  12. XM_017003847.1XP_016859336.1  SH2 domain-containing protein 6 isoform X8

    Conserved Domains (1) summary
    cl15255
    Location:227316
    SH2; Src homology 2 (SH2) domain
  13. XM_017003840.1XP_016859329.1  SH2 domain-containing protein 6 isoform X2

    Conserved Domains (1) summary
    cd09929
    Location:222343
    SH2_BLNK_SLP-76; Src homology 2 (SH2) domain found in B-cell linker (BLNK) protein and SH2 domain-containing leukocyte protein of 76 kDa (SLP-76)
  14. XM_017003851.1XP_016859340.1  SH2 domain-containing protein 6 isoform X12

    Conserved Domains (1) summary
    cd09929
    Location:126247
    SH2_BLNK_SLP-76; Src homology 2 (SH2) domain found in B-cell linker (BLNK) protein and SH2 domain-containing leukocyte protein of 76 kDa (SLP-76)
  15. XM_017003849.1XP_016859338.1  SH2 domain-containing protein 6 isoform X10

    Conserved Domains (1) summary
    cd09929
    Location:190311
    SH2_BLNK_SLP-76; Src homology 2 (SH2) domain found in B-cell linker (BLNK) protein and SH2 domain-containing leukocyte protein of 76 kDa (SLP-76)
  16. XM_017003842.1XP_016859331.1  SH2 domain-containing protein 6 isoform X4

    Related
    ENSP00000498488.1, ENST00000651736.1
    Conserved Domains (2) summary
    cd09929
    Location:213334
    SH2_BLNK_SLP-76; Src homology 2 (SH2) domain found in B-cell linker (BLNK) protein and SH2 domain-containing leukocyte protein of 76 kDa (SLP-76)
    cl41773
    Location:91211
    SP1-4_N; N-terminal domain of transcription factor Specificity Proteins (SP) 1-4
  17. XM_017003843.1XP_016859332.1  SH2 domain-containing protein 6 isoform X6

    Conserved Domains (1) summary
    cd09929
    Location:205326
    SH2_BLNK_SLP-76; Src homology 2 (SH2) domain found in B-cell linker (BLNK) protein and SH2 domain-containing leukocyte protein of 76 kDa (SLP-76)
  18. XM_017003846.1XP_016859335.1  SH2 domain-containing protein 6 isoform X7

    Conserved Domains (1) summary
    cd09929
    Location:195316
    SH2_BLNK_SLP-76; Src homology 2 (SH2) domain found in B-cell linker (BLNK) protein and SH2 domain-containing leukocyte protein of 76 kDa (SLP-76)
  19. XM_017003850.1XP_016859339.1  SH2 domain-containing protein 6 isoform X11

  20. XM_017003837.1XP_016859326.1  SH2 domain-containing protein 6 isoform X1

    Conserved Domains (1) summary
    cd09929
    Location:223344
    SH2_BLNK_SLP-76; Src homology 2 (SH2) domain found in B-cell linker (BLNK) protein and SH2 domain-containing leukocyte protein of 76 kDa (SLP-76)
  21. XM_017003845.1XP_016859334.1  SH2 domain-containing protein 6 isoform X6

    Conserved Domains (1) summary
    cd09929
    Location:205326
    SH2_BLNK_SLP-76; Src homology 2 (SH2) domain found in B-cell linker (BLNK) protein and SH2 domain-containing leukocyte protein of 76 kDa (SLP-76)
  22. XM_017003835.1XP_016859324.1  SH2 domain-containing protein 6 isoform X1

    Conserved Domains (1) summary
    cd09929
    Location:223344
    SH2_BLNK_SLP-76; Src homology 2 (SH2) domain found in B-cell linker (BLNK) protein and SH2 domain-containing leukocyte protein of 76 kDa (SLP-76)
  23. XM_017003844.1XP_016859333.1  SH2 domain-containing protein 6 isoform X6

    Conserved Domains (1) summary
    cd09929
    Location:205326
    SH2_BLNK_SLP-76; Src homology 2 (SH2) domain found in B-cell linker (BLNK) protein and SH2 domain-containing leukocyte protein of 76 kDa (SLP-76)
  24. XM_017003834.1XP_016859323.1  SH2 domain-containing protein 6 isoform X1

    Conserved Domains (1) summary
    cd09929
    Location:223344
    SH2_BLNK_SLP-76; Src homology 2 (SH2) domain found in B-cell linker (BLNK) protein and SH2 domain-containing leukocyte protein of 76 kDa (SLP-76)
  25. XM_011532783.1XP_011531085.1  SH2 domain-containing protein 6 isoform X5

    See identical proteins and their annotated locations for XP_011531085.1

    Conserved Domains (1) summary
    cd09929
    Location:212333
    SH2_BLNK_SLP-76; Src homology 2 (SH2) domain found in B-cell linker (BLNK) protein and SH2 domain-containing leukocyte protein of 76 kDa (SLP-76)
  26. XM_017003852.1XP_016859341.1  SH2 domain-containing protein 6 isoform X12

    Conserved Domains (1) summary
    cd09929
    Location:126247
    SH2_BLNK_SLP-76; Src homology 2 (SH2) domain found in B-cell linker (BLNK) protein and SH2 domain-containing leukocyte protein of 76 kDa (SLP-76)
  27. XM_017003859.1XP_016859348.1  SH2 domain-containing protein 6 isoform X17

  28. XM_017003860.1XP_016859349.1  SH2 domain-containing protein 6 isoform X15

    Conserved Domains (1) summary
    cd09929
    Location:49170
    SH2_BLNK_SLP-76; Src homology 2 (SH2) domain found in B-cell linker (BLNK) protein and SH2 domain-containing leukocyte protein of 76 kDa (SLP-76)
  29. XM_011532796.2XP_011531098.1  SH2 domain-containing protein 6 isoform X15

    Conserved Domains (1) summary
    cd09929
    Location:49170
    SH2_BLNK_SLP-76; Src homology 2 (SH2) domain found in B-cell linker (BLNK) protein and SH2 domain-containing leukocyte protein of 76 kDa (SLP-76)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_198482.1: Suppressed sequence

    Description
    NM_198482.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
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