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GPR26 G protein-coupled receptor 26 [ Homo sapiens (human) ]

Gene ID: 2849, updated on 17-Jun-2024

Summary

Official Symbol
GPR26provided by HGNC
Official Full Name
G protein-coupled receptor 26provided by HGNC
Primary source
HGNC:HGNC:4481
See related
Ensembl:ENSG00000154478 MIM:604847; AllianceGenome:HGNC:4481
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This gene encodes a G protein-couple receptor protein. G-protein-coupled receptors are a large family of membrane proteins that are involved in cellular responses to environmental stimuli, neurotransmitters, and hormones. The encoded protein may play a role in neurodegenerative diseases. Epigenetic silencing of this gene has been observed in gliomas. [provided by RefSeq, Sep 2016]
Expression
Restricted expression toward brain (RPKM 2.1) See more
Orthologs
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Genomic context

See GPR26 in Genome Data Viewer
Location:
10q26.13
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (123666355..123697399)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (124543147..124574217)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (125425871..125456915)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107984275 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4152 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:124984539-124985040 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:125034867-125035366 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4153 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2904 Neighboring gene long intergenic non-protein coding RNA 2641 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4154 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4155 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4156 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4157 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4158 Neighboring gene VISTA enhancer hs578 Neighboring gene ReSE screen-validated silencer GRCh37_chr10:125194236-125194421 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4159 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:125206418-125206918 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr10:125218162-125218857 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:125218858-125219552 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:125219553-125220248 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr10:125251140-125251910 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4160 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:125256249-125256976 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:125256977-125257703 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:125273408-125273955 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:125272859-125273407 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr10:125298302-125299501 Neighboring gene uncharacterized LOC105378530 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:125309926-125310436 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:125310437-125310946 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4161 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:125317863-125318581 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:125347653-125348156 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr10:125366796-125367386 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:125399083-125399626 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:125399627-125400170 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:125425617-125426155 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:125426156-125426693 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:125425079-125425616 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:125430545-125431046 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:125443142-125443642 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:125443643-125444143 Neighboring gene uncharacterized LOC105378532 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:125488883-125489382 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:125506649-125507630 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:125520224-125521126 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:125521127-125522029 Neighboring gene uncharacterized LOC105378533 Neighboring gene carboxypeptidase X, M14 family member 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
Association of genome-wide variation with highly sensitive cardiac troponin-T levels in European Americans and Blacks: a meta-analysis from atherosclerosis risk in communities and cardiovascular health studies.
EBI GWAS Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • FLJ33774, MGC138216, DKFZp761H2121

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G protein-coupled receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables G protein-coupled receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
G-protein coupled receptor 26

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_051571.1 RefSeqGene

    Range
    5001..36045
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_153442.4NP_703143.1  G-protein coupled receptor 26

    See identical proteins and their annotated locations for NP_703143.1

    Status: REVIEWED

    Source sequence(s)
    AC009987, AI076749, AJ505757, AK091093
    Consensus CDS
    CCDS7636.1
    UniProtKB/Swiss-Prot
    Q2M2E2, Q8NDV2
    Related
    ENSP00000284674.1, ENST00000284674.2
    Conserved Domains (1) summary
    cd15219
    Location:7305
    7tmA_GPR26_GPR78-like; G protein-coupled receptors 26 and 78, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

    Range
    123666355..123697399
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060934.1 Alternate T2T-CHM13v2.0

    Range
    124543147..124574217
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)