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C20orf203 chromosome 20 open reading frame 203 [ Homo sapiens (human) ]

Gene ID: 284805, updated on 5-Aug-2022

Summary

Official Symbol
C20orf203provided by HGNC
Official Full Name
chromosome 20 open reading frame 203provided by HGNC
Primary source
HGNC:HGNC:26592
See related
Ensembl:ENSG00000198547 AllianceGenome:HGNC:26592
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
The protein encoded by this gene is thought to be a human-specific protein. Currently available evidence suggests that orthologous regions in other organisms contain sequence differences that would not support production of a protein product. Genome-wide association studies have suggested the possibility that a SNP in the 3' UTR, rs17123507, could be associated with nicotine addiction. Expression of this gene may be elevated in some individuals with Alzheimer's disease. [provided by RefSeq, Mar 2017]
Expression
Low expression observed in reference dataset See more
Orthologs
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Genomic context

See C20orf203 in Genome Data Viewer
Location:
20q11.21
Exon count:
7
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 20 NC_000020.11 (32631625..32673941, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 20 NC_060944.1 (34360296..34402612, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (31219427..31261743, complement)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene nucleolar protein 4 like Neighboring gene Sharpr-MPRA regulatory region 4335 Neighboring gene NOL4L divergent transcript Neighboring gene H3K27ac-H3K4me1 hESC enhancers GRCh37_chr20:31268822-31269421 and GRCh37_chr20:31269422-31270020 Neighboring gene BCL2 antagonist/killer 1 pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ33706

Gene Ontology Provided by GOA

Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
uncharacterized protein C20orf203
Names
alugen

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_182584.4NP_872390.2  uncharacterized protein C20orf203

    See identical proteins and their annotated locations for NP_872390.2

    Status: VALIDATED

    Source sequence(s)
    BC105014, BM662904, FO393400, GU931819
    Consensus CDS
    CCDS13203.1
    UniProtKB/Swiss-Prot
    B8JHY2, Q8NBC4
    Related
    ENSP00000495424.1, ENST00000608990.6

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p14 Primary Assembly

    Range
    32631625..32673941 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047440131.1XP_047296087.1  uncharacterized protein C20orf203 isoform X1

    UniProtKB/Swiss-Prot
    B8JHY2
    Related
    ENSP00000495162.1, ENST00000360785.6
  2. XM_024451878.2XP_024307646.1  uncharacterized protein C20orf203 isoform X1

    UniProtKB/Swiss-Prot
    B8JHY2

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060944.1 Alternate T2T-CHM13v2.0

    Range
    34360296..34402612 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NR_026959.1: Suppressed sequence

    Description
    NR_026959.1: This RefSeq was permanently suppressed because it is now thought that this gene does encode a protein.