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dgoD D-galactonate dehydratase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 2847765, updated on 9-Mar-2023

Summary

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Gene symbol
dgoD
Gene description
D-galactonate dehydratase
Primary source
ASAP:ABE-0174106
Locus tag
b4478
See related
ECOCYC:GB4478
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
b3692; ECK3684; yidU
Summary
A genome sequence error, now repaired, previously fused dgoA and dgoD. [More information is available at EcoGene: EG20050]. D-galactonate dehydratase catalyzes the first step in the degradation of D-galactonate, the dehydration of D-galactonate to form 2-dehydro-3-deoxygalactonate . [More information is available at EcoCyc: GB4478].
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Genomic context

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Sequence:
NC_000913.3 (3871850..3872998, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene DUF3748 domain-containing galacturonate catabolism protein YidR Neighboring gene colicin M resistance protein Neighboring gene D-galactonate:H(+) symporter Neighboring gene 2-dehydro-3-deoxy-6-phosphogalactonate aldolase Neighboring gene 2-dehydro-3-deoxygalactonokinase Neighboring gene DNA-binding transcriptional regulator DgoR Neighboring gene putative lipoprotein YidX

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A functionally diverse enzyme superfamily that abstracts the alpha protons of carboxylic acids. Babbitt PC, et al. Science, 1995 Feb 24. PMID 7855594
  2. Divergent evolution in the enolase superfamily: the interplay of mechanism and specificity. Gerlt JA, et al. Arch Biochem Biophys, 2005 Jan 1. PMID 15581566
  3. The utilisation of D-galactonate and D-2-oxo-3-deoxygalactonate by Escherichia coli K-12. Biochemical and genetical studies. Cooper RA. Arch Microbiol, 1978 Aug 1. PMID 211976
  4. D-Galactonate utilisation by enteric bacteria. The catabolic pathway in Escherichia coli. Deacon J, et al. FEBS Lett, 1977 May 15. PMID 324806
  5. Molecular and Functional Insights into the Regulation of d-Galactonate Metabolism by the Transcriptional Regulator DgoR in Escherichia coli. Singh B, et al. J Bacteriol, 2019 Feb 15. PMID 30455279, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. N-terminus verified by Edman degradation on complete protein
    Title: A functionally diverse enzyme superfamily that abstracts the alpha protons of carboxylic acids.
Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by GO

Function Evidence Code Pubs
enables galactonate dehydratase activity IEA
Inferred from Electronic Annotation
more info
  
enables lyase activity IEA
Inferred from Electronic Annotation
more info
  
enables magnesium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in D-galactonate catabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within D-galactonate catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in amino acid catabolic process IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
D-galactonate dehydratase
YP_026237.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    3871850..3872998 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. YP_026237.1 D-galactonate dehydratase [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for YP_026237.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    Q6BF17
    Conserved Domains (1) summary
    PRK14017
    Location:1 → 382
    PRK14017; galactonate dehydratase; Provisional
Nucleotide Protein
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