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nirC nitrite transporter NirC [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 2847757, updated on 30-Jul-2025
Official Symbol
nirC
Official Full Name
nitrite transporter NirC
Primary source
ECOCYC:EG10654
Locus tag
b3367
See related
ASAP:ABE-0011008
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK3355
Summary
NirC is a nitrite transporter which is a member of the FNT family of formate and nitrite transporters . [More information is available at EcoCyc: EG10654].
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Sequence:
NC_000913.3 (3497003..3497809)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene putative transporter TsgA Neighboring gene nitrite reductase (NADH) large subunit Neighboring gene nitrite reductase (NADH) small subunit Neighboring gene siroheme synthase Neighboring gene DUF4223 domain-containing lipoprotein YhfL

Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Mechanism of nitrite transporter NirC in motility, biofilm formation, and adhesion of avian pathogenic Escherichia coli. Liu J, et al. Arch Microbiol, 2021 Sep. PMID 34091701
  2. Suppression of FNR-dependent transcription activation at the Escherichia coli nir promoter by Fis, IHF and H-NS: modulation of transcription initiation by a complex nucleo-protein assembly. Browning DF, et al. Mol Microbiol, 2000 Sep. PMID 10972841
  3. Transcriptional control of the cysG gene of Escherichia coli K-12 during aerobic and anaerobic growth. Peakman T, et al. Eur J Biochem, 1990 Jul 31. PMID 2200673
  4. Cloning of binding sequences for the Escherichia coli transcription activators, FNR and CRP: location of bases involved in discrimination between FNR and CRP. Bell AI, et al. Nucleic Acids Res, 1989 May 25. PMID 2543955, Free PMC Article
  5. Role of the Escherichia coli nitrate transport protein, NarU, in survival during severe nutrient starvation and slow growth. Clegg SJ, et al. Microbiology (Reading), 2006 Jul. PMID 16804183

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Mechanism of nitrite transporter NirC in motility, biofilm formation, and adhesion of avian pathogenic Escherichia coli.
    Title: Mechanism of nitrite transporter NirC in motility, biofilm formation, and adhesion of avian pathogenic Escherichia coli.
  2. A NarU+ NirC+ strain grew more rapidly and accumulated nitrite more rapidly than the isogenic NarU+ NirC(-) strain. Only the NirC+ strain consumed nitrite rapidly during the later stages of growth.
    Title: A single channel for nitrate uptake, nitrite export and nitrite uptake by Escherichia coli NarU and a role for NirC in nitrite export and uptake.
Submit: New GeneRIF Correction

Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables formate transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nitrite transmembrane transporter activity EXP
Inferred from Experiment
more info
 PubMed 
enables transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in formate transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in nitrate assimilation IEA
Inferred from Electronic Annotation
more info
  
involved_in nitrite transport EXP
Inferred from Experiment
more info
 PubMed 
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
nitrite transporter NirC

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    3497003..3497809
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. YP_026212.2 nitrite transporter NirC

    See identical proteins and their annotated locations for YP_026212.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0AAN3MB84
    Conserved Domains (1) summary
    PRK11562
    Location:1 → 268
    PRK11562; nitrite transporter NirC; Provisional
Nucleotide Protein
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