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ldrB small toxic polypeptide LdrB [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 2847735, updated on 25-Jun-2025
Official Symbol
ldrB
Official Full Name
small toxic polypeptide LdrB
Primary source
ECOCYC:G0-9605
Locus tag
b4421
See related
ASAP:ABE-0047281
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK1206
Summary
ldrB is one of a set of four Long Direct Repeats (LDRs), one of which has been shown to code for the toxin portion of a toxin-antitoxin pair. ldrA, ldrB and ldrC are clustered together as tandem repeats, with ldrD elsewhere on the genome. [More information is available at EcoCyc: G0-9605].
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Sequence:
NC_000913.3 (1269703..1269810, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene small toxic polypeptide LdrA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene small toxic polypeptide LdrC

Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Distribution of repetitive sequences on the leading and lagging strands of the Escherichia coli genome: comparative study of Long Direct Repeat (LDR) sequences. Kawano M, et al. DNA Res, 2002 Feb 28. PMID 11939563
  2. Hydrophobic peptides: novel regulators within bacterial membrane. Alix E, et al. Mol Microbiol, 2009 Apr. PMID 19210615
  3. Molecular characterization of long direct repeat (LDR) sequences expressing a stable mRNA encoding for a 35-amino-acid cell-killing peptide and a cis-encoded small antisense RNA in Escherichia coli. Kawano M, et al. Mol Microbiol, 2002 Jul. PMID 12123448
  4. Membranome: a database for proteome-wide analysis of single-pass membrane proteins. Lomize AL, et al. Nucleic Acids Res, 2017 Jan 4. PMID 27510400, Free PMC Article
  5. RNA antitoxins. Gerdes K, et al. Curr Opin Microbiol, 2007 Apr. PMID 17376733

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

Gene Ontology Provided by EcoCyc

Process Evidence Code Pubs
acts_upstream_of_or_within programmed cell death ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Component Evidence Code Pubs
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane RCA
inferred from Reviewed Computational Analysis
more info
 PubMed 
Preferred Names
small toxic polypeptide LdrB

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    1269703..1269810 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. YP_025298.1 small toxic polypeptide LdrB [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for YP_025298.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A6D0UYG9
    Conserved Domains (1) summary
    pfam13940
    Location:1 → 35
    Ldr_toxin; Toxin Ldr, type I toxin-antitoxin system
Nucleotide Protein
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