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hokB toxin HokB [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 2847727, updated on 20-Feb-2025

Summary

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Official Symbol
hokB
Official Full Name
toxin HokB
Primary source
ECOCYC:G0-9610
Locus tag
b4428
See related
ASAP:ABE-0047283
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK1412; ydcB
Summary
Sequence analysis indicates that the hokB gene is a homologue of the hok (host killing) gene which is responsible for mediating plasmid stabilization by post-segregational killing (PSK) in plasmid R1. hok encodes a stable mRNA whose translation is inhibited by a less stable mRNA encoded by sok. [More information is available at EcoCyc: G0-9610].
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Genomic context

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Sequence:
NC_000913.3 (1491922..1492071, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene protein YdcA Neighboring gene protein YncP Neighboring gene putative regulatory protein MokB Neighboring gene ncRNA Neighboring gene methyl-accepting chemotaxis protein Trg

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The Persistence-Inducing Toxin HokB Forms Dynamic Pores That Cause ATP Leakage. Wilmaerts D, et al. mBio, 2018 Aug 14. PMID 30108166, Free PMC Article
  2. Postoperative adrenal cortical insufficiency; occurrence in patients previously treated with cortisone. SALASSA RM, et al. J Am Med Assoc, 1953 Aug 15. PMID 13061310
  3. Biochemical determinants of ObgE-mediated persistence. Verstraeten N, et al. Mol Microbiol, 2019 Nov. PMID 31498933
  4. Nucleotide sequence of the cybB gene encoding cytochrome b561 in Escherichia coli K12. Nakamura H, et al. Mol Gen Genet, 1988 Apr. PMID 2836696
  5. Obg and Membrane Depolarization Are Part of a Microbial Bet-Hedging Strategy that Leads to Antibiotic Tolerance. Verstraeten N, et al. Mol Cell, 2015 Jul 2. PMID 26051177

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Gene Ontology Provided by EcoCyc

Process Evidence Code Pubs
involved_in dormancy process IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within dormancy process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane RCA
inferred from Reviewed Computational Analysis
more info
 PubMed 

General protein information

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Preferred Names
toxin HokB

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    1491922..1492071 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. YP_025301.1 toxin HokB [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for YP_025301.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A286MK15
    Conserved Domains (1) summary
    PRK09738
    Location:1 → 49
    PRK09738; small toxic polypeptide; Provisional
Nucleotide Protein
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