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tdcG L-serine deaminase III [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 2847724, updated on 23-Apr-2026
Official Symbol
tdcG
Official Full Name
L-serine deaminase III
Primary source
ECOCYC:G7624
Locus tag
b4471
See related
ASAP:ABE-0174101
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
b3111; b3112; ECK3101; sdhY; tdcGa; yhaP; yhaQ
Summary
L-serine deaminase III (TdcG) is one of three enzymes carrying out the sole step in the pathway of L-serine degradation, converting serine into a basic cellular building block, pyruvate. [More information is available at EcoCyc: G7624].
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Sequence:
NC_000913.3 (3258285..3259649, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene L-cysteine desulfidase Neighboring gene L-cysteine importer Neighboring gene putative enamine/imine deaminase Neighboring gene 2-oxobutanoate formate-lyase/pyruvate formate-lyase 4

Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Deficiency in l-serine deaminase results in abnormal growth and cell division of Escherichia coli K-12. Zhang X, et al. Mol Microbiol, 2008 Aug. PMID 18532981
  2. Threonine deamination in Escherichia coli. II. Evidence for two L-threonine deaminases. UMBARGER HE, et al. J Bacteriol, 1957 Jan. PMID 13405870, Free PMC Article
  3. Structure and function of enzymes involved in the anaerobic degradation of L-threonine to propionate. Simanshu DK, et al. J Biosci, 2007 Sep. PMID 17954980
  4. A novel mechanism controls anaerobic and catabolite regulation of the Escherichia coli tdc operon. Sawers G. Mol Microbiol, 2001 Mar. PMID 11251844
  5. Physical map location of the tdc operon of Escherichia coli. Schweizer HP, et al. J Bacteriol, 1990 Jun. PMID 2188941, Free PMC Article

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. integrity of the [4Fe-4S]2+ cluster is essential for enzyme activity
    Title: The iron-sulfur cluster in the L-serine dehydratase TdcG from Escherichia coli is required for enzyme activity.
Submit: New GeneRIF Correction
Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables 4 iron, 4 sulfur cluster binding IEA
Inferred from Electronic Annotation
more info
  
enables L-serine ammonia-lyase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables L-serine ammonia-lyase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables L-serine ammonia-lyase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within amino acid catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in amino acid catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in gluconeogenesis IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
L-serine deaminase III
YP_026204.1

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    3258285..3259649 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. YP_026204.1 L-serine deaminase III

    See identical proteins and their annotated locations for YP_026204.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A1X3JCI7
    Conserved Domains (1) summary
    PRK15040
    Location:1 → 454
    PRK15040; L-serine ammonia-lyase
Nucleotide Protein
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