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yghJ putative mayloidogenic protein [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 2847716, updated on 6-Jul-2026
Official Symbol
yghJ
Official Full Name
putative mayloidogenic protein
Primary source
ECOCYC:G7541
Locus tag
b4466
See related
ASAP:ABE-0174096
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
b2973; b2974; ECK2968; sslE
Summary
YghJ is homologous to V. cholerae accessory colonization factor AcfD. [More information is available at EcoGene: EG12994]. YghJ is a hypothetical protein. [More information is available at EcoCyc: G7541].
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Sequence:
NC_000913.3 (3114550..3119112, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene outer membrane pilotin Neighboring gene prepilin peptidase Neighboring gene glycolate/lactate:H(+) symporter GlcA Neighboring gene malate synthase G

Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Linking inherent O-Linked Protein Glycosylation of YghJ to Increased Antigen Potential. Thorsing M, et al. Front Cell Infect Microbiol, 2021. PMID 34490144, Free PMC Article
  2. Differential Regulation of the Surface-Exposed and Secreted SslE Lipoprotein in Extraintestinal Pathogenic Escherichia coli. Tan L, et al. PLoS One, 2016. PMID 27598999, Free PMC Article
  3. SslE elicits functional antibodies that impair in vitro mucinase activity and in vivo colonization by both intestinal and extraintestinal Escherichia coli strains. Nesta B, et al. PLoS Pathog, 2014 May. PMID 24809621, Free PMC Article
  4. Enterotoxigenic Escherichia coli secretes a highly conserved mucin-degrading metalloprotease to effectively engage intestinal epithelial cells. Luo Q, et al. Infect Immun, 2014 Feb. PMID 24478067, Free PMC Article
  5. Transposition is modulated by a diverse set of host factors in Escherichia coli and is stimulated by nutritional stress. Twiss E, et al. Mol Microbiol, 2005 Sep. PMID 16135227

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Linking inherent O-Linked Protein Glycosylation of YghJ to Increased Antigen Potential.
    Title: Linking inherent O-Linked Protein Glycosylation of YghJ to Increased Antigen Potential.
  2. SslE promotes macrophage activation and M1 polarization, which are crucial in framing the host's innate immune response to this protein.
    Title: SslE (YghJ), a Cell-Associated and Secreted Lipoprotein of Neonatal Septicemic Escherichia coli, Induces Toll-Like Receptor 2-Dependent Macrophage Activation and Proinflammation through NF-κB and MAP Kinase Signaling.
  3. Differential regulation of the surface-exposed and secreted SslE lipoprotein in extraintestinal pathogenic Escherichia coli has been reported.
    Title: Differential Regulation of the Surface-Exposed and Secreted SslE Lipoprotein in Extraintestinal Pathogenic Escherichia coli.
  4. The authors showed that YghJ can cause extensive tissue damage in mouse ileum and is also able to induce significant fluid accumulation in a dose dependent manner in a mouse ileal loop (MIL) assay.
    Title: YghJ, the secreted metalloprotease of pathogenic E. coli induces hemorrhagic fluid accumulation in mouse ileal loop.
  5. SslE expression not only increases bacterial growth in the presence of mucosal substrates but it also facilitates E. coli penetration of the mucus.
    Title: Pathogenic E. coli exploits SslE mucinase activity to translocate through the mucosal barrier and get access to host cells.
  6. Importance of SslE in E. coli colonization of mucosal surfaces, which reinforce the use of this antigen as a component of a broadly protective vaccine against pathogenic E. coli species.
    Title: SslE elicits functional antibodies that impair in vitro mucinase activity and in vivo colonization by both intestinal and extraintestinal Escherichia coli strains.
  7. YghJ is a highly conserved metalloprotease that influences intestinal colonization of enterotoxigenic Escherichia coli by degrading the major mucins in the small intestine, MUC2 and MUC3.
    Title: Enterotoxigenic Escherichia coli secretes a highly conserved mucin-degrading metalloprotease to effectively engage intestinal epithelial cells.
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Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables transmembrane transporter binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
putative mayloidogenic protein

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    3114550..3119112 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. YP_026189.1 putative mayloidogenic protein

    See identical proteins and their annotated locations for YP_026189.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A1B1LYS9
    Conserved Domains (1) summary
    NF037974
    Location:106 → 1511
    SslE_AcfD_Zn_LP; SslE/AcfD family lipoprotein zinc metalloprotease
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

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