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rtcA RNA 3'-terminal phosphate cyclase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 2847707, updated on 23-Apr-2026
Official Symbol
rtcA
Official Full Name
RNA 3'-terminal phosphate cyclase
Primary source
ECOCYC:G7750
Locus tag
b4475
See related
ASAP:ABE-0174104
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
b3419; b3420; ECK3406; yhgJ; yhgK
Summary
RNA 3'-terminal phosphate cyclase converts the 3'-terminal phosphate of various RNA substrates into the 2',3'-cyclic phosphodiester in an ATP-dependent reaction. [More information is available at EcoCyc: G7750].
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Sequence:
NC_000913.3 (3555833..3556849, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene maltodextrin phosphorylase Neighboring gene DNA-binding transcriptional activator MalT Neighboring gene RNA-splicing ligase Neighboring gene DNA-binding transcriptional activator RtcR Neighboring gene pseudo

Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Characterization of the adenylation site in the RNA 3'-terminal phosphate cyclase from Escherichia coli. Billy E, et al. J Biol Chem, 1999 Dec 3. PMID 10574971
  2. Cyclases of the 3'-terminal phosphate in RNA: a new family of RNA processing enzymes conserved in eucarya, bacteria and archaea. Filipowicz W, et al. Acta Biochim Pol, 1998. PMID 10397337
  3. The human RNA 3'-terminal phosphate cyclase is a member of a new family of proteins conserved in Eucarya, Bacteria and Archaea. Genschik P, et al. EMBO J, 1997 May 15. PMID 9184239, Free PMC Article
  4. The nucleotide sequence of the malT gene encoding the positive regulator of the Escherichia coli maltose regulon. Cole ST, et al. Gene, 1986. PMID 3015733
  5. Crystal structure of RNA 3'-terminal phosphate cyclase, a ubiquitous enzyme with unusual topology. Palm GJ, et al. Structure, 2000 Jan 15. PMID 10673421

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables RNA-3'-phosphate cyclase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA-3'-phosphate cyclase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables RNA-3'-phosphate cyclase activity IEA
Inferred from Electronic Annotation
more info
  
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in RNA processing IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
RNA 3'-terminal phosphate cyclase
YP_026219.1

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    3555833..3556849 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. YP_026219.1 RNA 3'-terminal phosphate cyclase

    See identical proteins and their annotated locations for YP_026219.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A1X3IVR0, A0A1X3JBY9
    Conserved Domains (1) summary
    PRK04204
    Location:3 → 335
    PRK04204; RNA 3'-terminal phosphate cyclase
Nucleotide Protein
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