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cpxP periplasmic protein CpxP [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 2847688, updated on 3-Dec-2024
Official Symbol
cpxP
Official Full Name
periplasmic protein CpxP
Primary source
ECOCYC:G7816
Locus tag
b4484
See related
ASAP:ABE-0174117
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
b3913; ECK3906; yiiO
Summary
Involved in feedback inhibition of Cpx signal transduction. [More information is available at EcoGene: EG11872]. CpxP is involved in resistance to extracytoplasmic stresses . [More information is available at EcoCyc: G7816].
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Sequence:
NC_000913.3 (4105820..4106320)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene 6-hydroxyaminopurine reductase Neighboring gene sensor histidine kinase CpxA Neighboring gene DNA-binding transcriptional dual regulator CpxR Neighboring gene ncRNA Neighboring gene Zn(2(+))/Fe(2(+))/Cd(2(+)) exporter

Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. The role of the two-component systems Cpx and Arc in protein alterations upon gentamicin treatment in Escherichia coli. Ćudić E, et al. BMC Microbiol, 2017 Sep 18. PMID 28923010, Free PMC Article
  2. Structure of the periplasmic stress response protein CpxP. Thede GL, et al. J Bacteriol, 2011 May. PMID 21317318, Free PMC Article
  3. Optimization of the inefficient translation initiation region of the cpxP gene from Escherichia coli. Miot M, et al. Protein Sci, 2007 Nov. PMID 17905837, Free PMC Article
  4. Dynamic interaction between the CpxA sensor kinase and the periplasmic accessory protein CpxP mediates signal recognition in E. coli. Tschauner K, et al. PLoS One, 2014. PMID 25207645, Free PMC Article
  5. Cpx signaling pathway monitors biogenesis and affects assembly and expression of P pili. Hung DL, et al. EMBO J, 2001 Apr 2. PMID 11285215, Free PMC Article

See all (33) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The Cpx-TCS within the complex regulatory network in the E. coli response to aminoglycoside-caused stress.
    Title: The role of the two-component systems Cpx and Arc in protein alterations upon gentamicin treatment in Escherichia coli.
  2. CpxP modulates the activity of the Cpx system by dynamic interaction with CpxA in response to specific stresses.
    Title: Dynamic interaction between the CpxA sensor kinase and the periplasmic accessory protein CpxP mediates signal recognition in E. coli.
  3. We determined that K298 of RNA polymerase alpha is specifically required for glucose-induced cpxP transcription.
    Title: Involvement of protein acetylation in glucose-induced transcription of a stress-responsive promoter.
  4. periplasmic expression could be inhibited by sequence elements in the early coding signal sequence region of cpxP
    Title: Optimization of the inefficient translation initiation region of the cpxP gene from Escherichia coli.
  5. the N-terminal alpha-helix is an important functional domain for inhibition of the Cpx pathway and that CpxP is subject to DegP-dependent proteolysis
    Title: Cpx signal transduction is influenced by a conserved N-terminal domain in the novel inhibitor CpxP and the periplasmic protease DegP.
  6. biochemical analysis of the CpxRAP envelope stress system of Escherichia coli
    Title: Purification, reconstitution, and characterization of the CpxRAP envelope stress system of Escherichia coli.
  7. CpxP functions as a periplasmic adaptor protein that is required for the effective proteolysis of a subset of misfolded substrates by the DegP protease
    Title: The extracytoplasmic adaptor protein CpxP is degraded with substrate by DegP.
Submit: New GeneRIF Correction

Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables unfolded protein binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables unfolded protein binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables unfolded protein binding ISM
Inferred from Sequence Model
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within regulation of proteolysis EXP
Inferred from Experiment
more info
 PubMed 
acts_upstream_of_or_within response to stress IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
is_active_in outer membrane-bounded periplasmic space IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in outer membrane-bounded periplasmic space IDA
Inferred from Direct Assay
more info
 PubMed 
located_in periplasmic space IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
periplasmic protein CpxP

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    4105820..4106320
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. YP_026277.1 periplasmic protein CpxP [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for YP_026277.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A376FVD0
    Conserved Domains (1) summary
    PRK10363
    Location:1 → 166
    cpxP; cell-envelope stress modulator CpxP
Nucleotide Protein
Heading Accession and Version

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