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wecF TDP-N-acetylfucosamine:lipid II N-acetylfucosaminyltransferase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 2847677, updated on 19-Nov-2025
Official Symbol
wecF
Official Full Name
TDP-N-acetylfucosamine:lipid II N-acetylfucosaminyltransferase
Primary source
ECOCYC:G7800
Locus tag
b4481
See related
ASAP:ABE-0174115
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
b4404; b4405; ECK3785; rff; rffT; yifM
Summary
The rffT gene encodes Fuc4NAc (4-acetamido-4,6-dideoxy-D-galactose) transferase, which catalyzes a step in biosynthesis of lipid III during biosynthesis of enterobacterial common antigen (ECA) . [More information is available at EcoCyc: G7800].
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Sequence:
NC_000913.3 (3977525..3978604)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene glucose-1-phosphate thymidylyltransferase 2 Neighboring gene dTDP-4-amino-4,6-dideoxy-D-galactose acyltransferase Neighboring gene dTDP-4-dehydro-6-deoxy-D-glucose transaminase Neighboring gene lipid IIIECA flippase Neighboring gene enterobacterial common antigen polymerase Neighboring gene UDP-N-acetyl-D-mannosaminuronic acid transferase Neighboring gene threonine/serine:H(+) symporter ThrP

Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

GeneRIFs: Gene References Into Functions

Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables 4-acetamido-4,6-dideoxy-D-galactose transferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables 4-acetamido-4,6-dideoxy-D-galactose transferase activity IEA
Inferred from Electronic Annotation
more info
  
enables fucosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables glycosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables hexosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in enterobacterial common antigen biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within enterobacterial common antigen biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
TDP-N-acetylfucosamine:lipid II N-acetylfucosaminyltransferase
YP_026257.1

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    3977525..3978604
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. YP_026257.1 TDP-N-acetylfucosamine:lipid II N-acetylfucosaminyltransferase

    See identical proteins and their annotated locations for YP_026257.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A376FV33
    Conserved Domains (1) summary
    pfam07429
    Location:1 → 356
    Glyco_transf_56; 4-alpha-L-fucosyltransferase glycosyl transferase group 56
Nucleotide Protein
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