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LPAR4 lysophosphatidic acid receptor 4 [ Homo sapiens (human) ]

Gene ID: 2846, updated on 13-Mar-2020

Summary

Official Symbol
LPAR4provided by HGNC
Official Full Name
lysophosphatidic acid receptor 4provided by HGNC
Primary source
HGNC:HGNC:4478
See related
Ensembl:ENSG00000147145 MIM:300086
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
LPA4; P2Y9; GPR23; P2RY9; P2Y5-LIKE
Summary
This gene encodes a member of the lysophosphatidic acid receptor family. It may also be related to the P2Y receptors, a family of receptors that bind purine and pyrimidine nucleotides and are coupled to G proteins. The encoded protein may play a role in monocytic differentiation. [provided by RefSeq, Feb 2009]
Expression
Low expression observed in reference dataset See more
Orthologs

Genomic context

See LPAR4 in Genome Data Viewer
Location:
Xq21.1
Exon count:
5
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) X NC_000023.11 (78747658..78758714)
105 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (78003206..78014211)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107985670 Neighboring gene retrotransposon Gag like 3 Neighboring gene phosphoribosyl pyrophosphate amidotransferase pseudogene 2 Neighboring gene ribosomal protein L7 pseudogene 54 Neighboring gene microRNA 4328

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
G protein-coupled receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
lysophosphatidic acid binding IEA
Inferred from Electronic Annotation
more info
 
lysophosphatidic acid receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
cell IEA
Inferred from Electronic Annotation
more info
 
integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
 
nuclear body IDA
Inferred from Direct Assay
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
lysophosphatidic acid receptor 4
Names
G-protein coupled receptor 23
LPA receptor 4
LPA-4
P2Y purinoceptor 9
P2Y5-like receptor
purinergic receptor 9

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_013242.1 RefSeqGene

    Range
    5012..14404
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001278000.1NP_001264929.1  lysophosphatidic acid receptor 4

    See identical proteins and their annotated locations for NP_001264929.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AU129897, DA368656, DA735126, U90322
    Consensus CDS
    CCDS14441.1
    UniProtKB/Swiss-Prot
    Q99677
    Related
    ENSP00000478261.1, ENST00000614823.4
    Conserved Domains (2) summary
    pfam00001
    Location:57311
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:51165
    7tm_4; Olfactory receptor
  2. NM_005296.3NP_005287.1  lysophosphatidic acid receptor 4

    See identical proteins and their annotated locations for NP_005287.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks alternate exons in the 5'UTR. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AA424772, AK314134, AL590083, BM973092, BX100826, U90322
    Consensus CDS
    CCDS14441.1
    UniProtKB/Swiss-Prot
    Q99677
    Related
    ENSP00000408205.2, ENST00000435339.3
    Conserved Domains (2) summary
    pfam00001
    Location:57311
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:51165
    7tm_4; Olfactory receptor

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p13 Primary Assembly

    Range
    78747658..78758714
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005262126.3XP_005262183.1  lysophosphatidic acid receptor 4 isoform X1

    See identical proteins and their annotated locations for XP_005262183.1

    UniProtKB/Swiss-Prot
    Q99677
    Conserved Domains (2) summary
    pfam00001
    Location:57311
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:51165
    7tm_4; Olfactory receptor
  2. XM_017029437.1XP_016884926.1  lysophosphatidic acid receptor 4 isoform X1

    UniProtKB/Swiss-Prot
    Q99677
    Conserved Domains (2) summary
    pfam00001
    Location:57311
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:51165
    7tm_4; Olfactory receptor
  3. XM_017029438.1XP_016884927.1  lysophosphatidic acid receptor 4 isoform X1

    UniProtKB/Swiss-Prot
    Q99677
    Conserved Domains (2) summary
    pfam00001
    Location:57311
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:51165
    7tm_4; Olfactory receptor
  4. XM_006724639.3XP_006724702.1  lysophosphatidic acid receptor 4 isoform X1

    See identical proteins and their annotated locations for XP_006724702.1

    UniProtKB/Swiss-Prot
    Q99677
    Conserved Domains (2) summary
    pfam00001
    Location:57311
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:51165
    7tm_4; Olfactory receptor
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