U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

SLC9C2 solute carrier family 9 member C2 (putative) [ Homo sapiens (human) ]

Gene ID: 284525, updated on 5-Aug-2022

Summary

Official Symbol
SLC9C2provided by HGNC
Official Full Name
solute carrier family 9 member C2 (putative)provided by HGNC
Primary source
HGNC:HGNC:28664
See related
Ensembl:ENSG00000162753 AllianceGenome:HGNC:28664
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SLC9A11
Summary
Predicted to enable potassium:proton antiporter activity and sodium:proton antiporter activity. Predicted to be involved in potassium ion transmembrane transport; regulation of intracellular pH; and sodium ion import across plasma membrane. Predicted to be integral component of membrane. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward testis (RPKM 4.6) See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See SLC9C2 in Genome Data Viewer
Location:
1q25.1
Exon count:
29
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (173500460..173603072, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (172858618..172961223, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (173469599..173572211, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124904456 Neighboring gene Sharpr-MPRA regulatory region 4744 Neighboring gene peroxiredoxin 6 Neighboring gene ankyrin repeat domain 45 Neighboring gene uncharacterized LOC105371619 Neighboring gene testis expressed 50 Neighboring gene small nucleolar RNA U13

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

General gene information

Markers

Homology

Clone Names

  • MGC43026

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables potassium:proton antiporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables sodium:proton antiporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in potassium ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in proton transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of intracellular pH IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in sodium ion import across plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
sodium/hydrogen exchanger 11
Names
NHE-11
Na(+)/H(+) exchanger 11
solute carrier family 9, member 11

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_178527.4NP_848622.2  sodium/hydrogen exchanger 11

    See identical proteins and their annotated locations for NP_848622.2

    Status: VALIDATED

    Source sequence(s)
    AK128104, AL139142, BC042592, DB071569
    Consensus CDS
    CCDS1308.1
    UniProtKB/Swiss-Prot
    Q5TAH2, Q86UF3
    UniProtKB/TrEMBL
    B3KXW8
    Related
    ENSP00000356687.3, ENST00000367714.4
    Conserved Domains (3) summary
    cd00038
    Location:873980
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
    pfam00520
    Location:638731
    Ion_trans; Ion transport protein
    cl01133
    Location:98380
    Na_H_Exchanger; Sodium/hydrogen exchanger family

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    173500460..173603072 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047418170.1XP_047274126.1  sodium/hydrogen exchanger 11 isoform X6

  2. XM_017001074.2XP_016856563.1  sodium/hydrogen exchanger 11 isoform X5

  3. XM_047418169.1XP_047274125.1  sodium/hydrogen exchanger 11 isoform X6

  4. XM_017001073.2XP_016856562.1  sodium/hydrogen exchanger 11 isoform X5

  5. XM_017001071.2XP_016856560.1  sodium/hydrogen exchanger 11 isoform X3

  6. XM_017001070.2XP_016856559.1  sodium/hydrogen exchanger 11 isoform X2

  7. XM_017001066.2XP_016856555.1  sodium/hydrogen exchanger 11 isoform X1

    Conserved Domains (3) summary
    cd00038
    Location:873980
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
    pfam00520
    Location:638731
    Ion_trans; Ion transport protein
    cl01133
    Location:98380
    Na_H_Exchanger; Sodium/hydrogen exchanger family
  8. XM_017001069.3XP_016856558.1  sodium/hydrogen exchanger 11 isoform X2

  9. XM_017001065.3XP_016856554.1  sodium/hydrogen exchanger 11 isoform X1

    Conserved Domains (3) summary
    cd00038
    Location:873980
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
    pfam00520
    Location:638731
    Ion_trans; Ion transport protein
    cl01133
    Location:98380
    Na_H_Exchanger; Sodium/hydrogen exchanger family
  10. XM_017001072.3XP_016856561.1  sodium/hydrogen exchanger 11 isoform X4

  11. XM_017001068.3XP_016856557.1  sodium/hydrogen exchanger 11 isoform X2

  12. XM_011509426.3XP_011507728.1  sodium/hydrogen exchanger 11 isoform X1

    Conserved Domains (3) summary
    cd00038
    Location:873980
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
    pfam00520
    Location:638731
    Ion_trans; Ion transport protein
    cl01133
    Location:98380
    Na_H_Exchanger; Sodium/hydrogen exchanger family
  13. XM_017001075.2XP_016856564.1  sodium/hydrogen exchanger 11 isoform X7

    Related
    ENST00000466087.1
  14. XM_017001076.2XP_016856565.1  sodium/hydrogen exchanger 11 isoform X8

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    172858618..172961223 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)