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THEM5 thioesterase superfamily member 5 [ Homo sapiens (human) ]

Gene ID: 284486, updated on 18-Aug-2020

Summary

Official Symbol
THEM5provided by HGNC
Official Full Name
thioesterase superfamily member 5provided by HGNC
Primary source
HGNC:HGNC:26755
See related
Ensembl:ENSG00000196407 MIM:615653
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ACOT15
Expression
Biased expression in skin (RPKM 49.5) and brain (RPKM 1.6) See more
Orthologs

Genomic context

See THEM5 in Genome Data Viewer
Location:
1q21.3
Exon count:
6
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (151847101..151853712, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (151818220..151826173, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene RAR related orphan receptor C Neighboring gene C2CD4D and THEM5 antisense RNA 1 Neighboring gene C2 calcium dependent domain containing 4D Neighboring gene thioesterase superfamily member 4 Neighboring gene keratin 8 pseudogene 28

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ37964, MGC126659, MGC138444

Gene Ontology Provided by GOA

Function Evidence Code Pubs
myristoyl-CoA hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
palmitoyl-CoA hydrolase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
palmitoyl-CoA hydrolase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
acyl-CoA metabolic process TAS
Traceable Author Statement
more info
 
cardiolipin acyl-chain remodeling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cardiolipin acyl-chain remodeling ISS
Inferred from Sequence or Structural Similarity
more info
 
fatty acid metabolic process IEA
Inferred from Electronic Annotation
more info
 
long-chain fatty-acyl-CoA metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
long-chain fatty-acyl-CoA metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
mitochondrial matrix IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitochondrial matrix IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrial matrix TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
acyl-coenzyme A thioesterase THEM5
Names
acyl-CoA thioesterase THEM5
acyl-coenzyme A thioesterase 15
NP_872384.2
XP_011507723.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_182578.4NP_872384.2  acyl-coenzyme A thioesterase THEM5

    Status: VALIDATED

    Source sequence(s)
    AL450992
    Consensus CDS
    CCDS1005.1
    Related
    ENSP00000357807.4, ENST00000368817.10
    Conserved Domains (1) summary
    cd03443
    Location:141237
    PaaI_thioesterase; PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    151847101..151853712 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011509421.1XP_011507723.1  acyl-coenzyme A thioesterase THEM5 isoform X1

    Conserved Domains (2) summary
    cd03443
    Location:141210
    PaaI_thioesterase; PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not ...
    cl11394
    Location:197240
    Glyco_tranf_GTA_type; Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold
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