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TAFA3 TAFA chemokine like family member 3 [ Homo sapiens (human) ]

Gene ID: 284467, updated on 11-Jun-2021

Summary

Official Symbol
TAFA3provided by HGNC
Official Full Name
TAFA chemokine like family member 3provided by HGNC
Primary source
HGNC:HGNC:21590
See related
Ensembl:ENSG00000184599 MIM:617497
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TAFA-3; FAM19A3
Summary
This gene is a member of the TAFA family which is composed of five highly homologous genes that encode small secreted proteins. These proteins contain conserved cysteine residues at fixed positions, and are distantly related to MIP-1alpha, a member of the CC-chemokine family. The TAFA proteins are predominantly expressed in specific regions of the brain, and are postulated to function as brain-specific chemokines or neurokines, that act as regulators of immune and nervous cells. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011]
Expression
Biased expression in adrenal (RPKM 7.0) and testis (RPKM 3.0) See more
Orthologs
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Genomic context

See TAFA3 in Genome Data Viewer
Location:
1p13.2
Exon count:
6
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (112718905..112727235)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (113261527..113269857)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 11832 Neighboring gene PPM1J divergent transcript Neighboring gene nuclear transport factor 2 pseudogene 4 Neighboring gene long intergenic non-protein coding RNA 1356 Neighboring gene long intergenic non-protein coding RNA 1357

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC138473

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables receptor ligand activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in negative regulation of microglial cell activation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in negative regulation of microglial cell activation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in neuroblast differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of microglial cell activation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of microglial cell activation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of neuroblast proliferation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in extracellular space IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
chemokine-like protein TAFA-3
Names
family with sequence similarity 19 (chemokine (C-C motif)-like), member A3
family with sequence similarity 19 member A3, C-C motif chemokine like
protein FAM19A3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001004440.2NP_001004440.1  chemokine-like protein TAFA-3 isoform 2 precursor

    See identical proteins and their annotated locations for NP_001004440.1

    Status: REVIEWED

    Source sequence(s)
    AL603832
    Consensus CDS
    CCDS30806.1
    UniProtKB/Swiss-Prot
    Q7Z5A8
    Related
    ENSP00000358644.3, ENST00000369630.7
    Conserved Domains (1) summary
    pfam12020
    Location:4388
    TAFA; TAFA family
  2. NM_182759.3NP_877436.1  chemokine-like protein TAFA-3 isoform 1 precursor

    See identical proteins and their annotated locations for NP_877436.1

    Status: REVIEWED

    Source sequence(s)
    AL603832
    Consensus CDS
    CCDS856.1
    UniProtKB/Swiss-Prot
    Q7Z5A8
    Related
    ENSP00000355042.3, ENST00000361886.4
    Conserved Domains (1) summary
    pfam12020
    Location:43131
    TAFA; TAFA family

RNA

  1. NR_169586.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL603832

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    112718905..112727235
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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