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ZNF493 zinc finger protein 493 [ Homo sapiens (human) ]

Gene ID: 284443, updated on 13-Mar-2020

Summary

Official Symbol
ZNF493provided by HGNC
Official Full Name
zinc finger protein 493provided by HGNC
Primary source
HGNC:HGNC:23708
See related
Ensembl:ENSG00000196268
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Ubiquitous expression in thyroid (RPKM 7.3), ovary (RPKM 5.3) and 25 other tissues See more
Orthologs

Genomic context

See ZNF493 in Genome Data Viewer
Location:
19p12
Exon count:
5
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (21397133..21427577)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (21579921..21610297)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene zinc finger protein 708 Neighboring gene BCL2 interacting protein 3 pseudogene 25 Neighboring gene zinc finger protein 738 Neighboring gene iron-sulfur cluster assembly 1 homolog (S. cerevisiae) pseudogene Neighboring gene uncharacterized LOC105372321 Neighboring gene long intergenic non-protein coding RNA 664

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ36504

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
DNA-binding transcription factor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
regulation of transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001076678.3NP_001070146.1  zinc finger protein 493 isoform 3

    See identical proteins and their annotated locations for NP_001070146.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) represents the longest transcript and encodes the longest isoform (3).
    Source sequence(s)
    AC010615, BX648842
    Consensus CDS
    CCDS42536.1
    UniProtKB/Swiss-Prot
    Q6ZR52
    Related
    ENSP00000376110.2, ENST00000392288.6
    Conserved Domains (5) summary
    smart00349
    Location:1373
    KRAB; krueppel associated box
    COG5048
    Location:262667
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:491511
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:1352
    KRAB; KRAB box
    pfam13465
    Location:363387
    zf-H2C2_2; Zinc-finger double domain
  2. NM_145326.3NP_663299.2  zinc finger protein 493 isoform 2

    See identical proteins and their annotated locations for NP_663299.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2), includes an alternate exon in the 3' coding region and 3' UTR, compared to variant 1. It encodes isoform 2, which is shorter and has a distinct C-terminus, compared to isoform 3.
    Source sequence(s)
    AC010615, BC006408, DA804007
    Consensus CDS
    CCDS12411.1
    UniProtKB/Swiss-Prot
    Q6ZR52
    Related
    ENSP00000340651.6, ENST00000339914.6
    Conserved Domains (2) summary
    smart00349
    Location:1374
    KRAB; krueppel associated box
    pfam01352
    Location:1352
    KRAB; KRAB box
  3. NM_175910.7NP_787106.4  zinc finger protein 493 isoform 1

    See identical proteins and their annotated locations for NP_787106.4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) lacks two exons resulting in use of a downstream start codon, compared to variant 3. It encodes isoform 1, which has a shorter and distinct N-terminus, compared to isoform 3.
    Source sequence(s)
    AB209086, AC010615, DA804007
    Consensus CDS
    CCDS12412.1
    UniProtKB/Swiss-Prot
    Q6ZR52
    Related
    ENSP00000347691.4, ENST00000355504.4
    Conserved Domains (3) summary
    COG5048
    Location:134539
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:363383
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:235259
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    21397133..21427577
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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