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GPR21 G protein-coupled receptor 21 [ Homo sapiens (human) ]

Gene ID: 2844, updated on 25-Aug-2020

Summary

Official Symbol
GPR21provided by HGNC
Official Full Name
G protein-coupled receptor 21provided by HGNC
Primary source
HGNC:HGNC:4476
See related
Ensembl:ENSG00000188394 MIM:601909
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This gene encodes a member of the G-protein-coupled receptor 1 family. G-protein coupled receptors are membrane proteins which activate signaling cascades as a response to extracellular stress. The encoded protein activates a Gq signal transduction pathway which mobilizes calcium. [provided by RefSeq, Nov 2012]
Expression
Low expression observed in reference dataset See more
Orthologs

Genomic context

See GPR21 in Genome Data Viewer
Location:
9q33.2
Exon count:
2
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) 9 NC_000009.12 (123033635..123042751)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (125795916..125801380)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene RAB GTPase activating protein 1 Neighboring gene RNY1 pseudogene 15 Neighboring gene ribosomal protein S25 pseudogene 8 Neighboring gene COP9 signalosome subunit 2 pseudogene Neighboring gene MIR600 host gene Neighboring gene microRNA 600 Neighboring gene spermatid perinuclear RNA binding protein

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
glucose homeostasis IEA
Inferred from Electronic Annotation
more info
 
negative regulation of insulin receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
positive regulation of multicellular organism growth IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
probable G-protein coupled receptor 21

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_005294.3NP_005285.1  probable G-protein coupled receptor 21

    See identical proteins and their annotated locations for NP_005285.1

    Status: REVIEWED

    Source sequence(s)
    AK299686, BC066885, DA792401, DN989991
    Consensus CDS
    CCDS6849.1
    UniProtKB/Swiss-Prot
    Q99679
    UniProtKB/TrEMBL
    B4DSD1, H9NIL4
    Related
    ENSP00000482287.1, ENST00000616002.2
    Conserved Domains (1) summary
    cd00637
    Location:31308
    7tm_classA_rhodopsin-like; rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor superfamily

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p13 Primary Assembly

    Range
    123033635..123042751
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005251933.4XP_005251990.1  probable G-protein coupled receptor 21 isoform X1

    See identical proteins and their annotated locations for XP_005251990.1

    UniProtKB/Swiss-Prot
    Q99679
    UniProtKB/TrEMBL
    H9NIL4
    Conserved Domains (1) summary
    cd00637
    Location:31308
    7tm_classA_rhodopsin-like; rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor superfamily
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