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TPRX1 tetrapeptide repeat homeobox 1 [ Homo sapiens (human) ]

Gene ID: 284355, updated on 21-Dec-2022

Summary

Official Symbol
TPRX1provided by HGNC
Official Full Name
tetrapeptide repeat homeobox 1provided by HGNC
Primary source
HGNC:HGNC:32174
See related
Ensembl:ENSG00000178928 MIM:611166; AllianceGenome:HGNC:32174
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TPRX
Summary
Homeobox genes encode DNA-binding proteins, many of which are thought to be involved in early embryonic development. Homeobox genes encode a DNA-binding domain of 60 to 63 amino acids referred to as the homeodomain. This gene is a member of the TPRX homeobox gene family. [provided by RefSeq, Jul 2008]
Expression
Low expression observed in reference dataset See more
Orthologs
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Genomic context

See TPRX1 in Genome Data Viewer
Location:
19q13.33
Exon count:
5
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (47801232..47819051, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (50632045..50649890, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (48304489..48322308, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene selenoprotein W Neighboring gene ribosomal protein L23a pseudogene 80 Neighboring gene cone-rod homeobox Neighboring gene tetrapeptide repeat homeobox 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General protein information

Preferred Names
tetra-peptide repeat homeobox protein 1
Names
CRX like homeobox 2
tetra-peptide repeat homeobox 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001397346.1NP_001384275.1  tetra-peptide repeat homeobox protein 1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC008745
    Consensus CDS
    CCDS92654.1
    UniProtKB/TrEMBL
    A0A8V8TMK4
    Related
    ENSP00000513863.1, ENST00000698655.1
    Conserved Domains (1) summary
    cd00086
    Location:2179
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
  2. NM_198479.3NP_940881.3  tetra-peptide repeat homeobox protein 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC008745
    Consensus CDS
    CCDS33066.2
    UniProtKB/TrEMBL
    D2CFI5
    Related
    ENSP00000438832.1, ENST00000535759.2
    Conserved Domains (1) summary
    pfam00046
    Location:66122
    Homeobox; Homeobox domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    47801232..47819051 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    50632045..50649890 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)