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CXCL17 C-X-C motif chemokine ligand 17 [ Homo sapiens (human) ]

Gene ID: 284340, updated on 29-Mar-2020

Summary

Official Symbol
CXCL17provided by HGNC
Official Full Name
C-X-C motif chemokine ligand 17provided by HGNC
Primary source
HGNC:HGNC:19232
See related
Ensembl:ENSG00000189377 MIM:611387
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DMC; VCC1; Dcip1; VCC-1; UNQ473
Summary
The protein encoded by this gene is a mucosal chemokine that attracts immature dendritic cells and blood monocytes to the lungs. The encoded protein also promotes tumorigenesis through an angiogenic activity. Finally, this protein exhibits strong antimicrobial activity against E. coli, S. aureus, Salmonella, P. aeruginosa, and C. albicans. Two transcript variants, one protein-coding and the other non-protein coding, have been found for this gene. [provided by RefSeq, Dec 2015]
Expression
Biased expression in stomach (RPKM 182.1), lung (RPKM 72.2) and 3 other tissues See more
Orthologs

Genomic context

See CXCL17 in Genome Data Viewer
Location:
19q13.2
Exon count:
4
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (42428278..42442946, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (42932695..42947136, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101930071 Neighboring gene LIPE antisense RNA 1 Neighboring gene cornifelin Neighboring gene lipase E, hormone sensitive type Neighboring gene RNA, U4 small nuclear 60, pseudogene Neighboring gene AN1-type zinc finger protein 5 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

General gene information

Markers

Homology

Clone Names

  • MGC138300

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
activation of MAPK activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
activation of MAPK activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
angiogenesis IEA
Inferred from Electronic Annotation
more info
 
cell differentiation IEA
Inferred from Electronic Annotation
more info
 
macrophage chemotaxis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of inflammatory response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of inflammatory response IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of macrophage chemotaxis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of macrophage chemotaxis IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of monocyte chemotaxis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of monocyte chemotaxis IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of vascular endothelial growth factor production IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of vascular endothelial growth factor production IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
extracellular space IMP
Inferred from Mutant Phenotype
more info
PubMed 

General protein information

Preferred Names
C-X-C motif chemokine 17
Names
6-Cys CXCL17
VEGF co-regulated chemokine 1
VEGF coregulated chemokine 1
chemokine (C-X-C motif) ligand 17
dendritic cell and monocyte chemokine-like protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_198477.3NP_940879.1  C-X-C motif chemokine 17 precursor

    See identical proteins and their annotated locations for NP_940879.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the protein-coding transcript.
    Source sequence(s)
    AC011497, AY358433, BU684368
    Consensus CDS
    CCDS12608.1
    UniProtKB/Swiss-Prot
    Q6UXB2
    Related
    ENSP00000472467.1, ENST00000601181.6
    Conserved Domains (1) summary
    pfam15211
    Location:23111
    CXCL17; VEGF co-regulated chemokine 1

RNA

  1. NR_133910.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate splice junction compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC011497, AY358433, AY598464, BM978124, BU684368

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    42428278..42442946 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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