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PRR19 proline rich 19 [ Homo sapiens (human) ]

Gene ID: 284338, updated on 25-Nov-2025
Official Symbol
PRR19provided by HGNC
Official Full Name
proline rich 19provided by HGNC
Primary source
HGNC:HGNC:33728
See related
Ensembl:ENSG00000188368 MIM:621177; AllianceGenome:HGNC:33728
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to be involved in meiotic cell cycle. Predicted to be located in chromosome and nucleus. [provided by Alliance of Genome Resources, Jul 2025]
Expression
Broad expression in testis (RPKM 6.5), brain (RPKM 1.5) and 20 other tissues See more
Orthologs
mouse all
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See PRR19 in Genome Data Viewer
Location:
19q13.2
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2025_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (42302132..42310814)
RS_2025_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (45121505..45130199)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (42806284..42814966)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10694 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10695 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10696 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10697 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:42758837-42759336 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:42759977-42760508 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:42761304-42762125 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:42762126-42762946 Neighboring gene ETS2 repressor factor Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14710 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14711 Neighboring gene ZFP161 motif-containing MPRA enhancer 284/285 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:42784339-42784844 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10703 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:42785857-42786361 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:42787942-42788116 Neighboring gene capicua transcriptional repressor Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:42794166-42795066 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10705 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14712 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14713 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:42806463-42807117 Neighboring gene platelet activating factor acetylhydrolase 1b catalytic subunit 3 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10707 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:42818801-42819301 Neighboring gene transmembrane protein 145 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10708 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10709 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10710 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10711 Neighboring gene multiple EGF like domains 8 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:42853955-42854456 Neighboring gene microRNA 8077

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Related articles in PubMed

  1. Assessment of community efforts to advance network-based prediction of protein-protein interactions. Wang XW, et al. Nat Commun, 2023 Mar 22. PMID 36949045, Free PMC Article
  2. Transcriptome analysis of human gastric cancer. Oh JH, et al. Mamm Genome, 2005 Dec. PMID 16341674
  3. Integrative oncogene-dependency mapping identifies RIT1 vulnerabilities and synergies in lung cancer. Vichas A, et al. Nat Commun, 2021 Aug 9. PMID 34373451, Free PMC Article
  4. A proteome-scale map of the human interactome network. Rolland T, et al. Cell, 2014 Nov 20. PMID 25416956, Free PMC Article
  5. A reference map of the human binary protein interactome. Luck K, et al. Nature, 2020 Apr. PMID 32296183, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • MGC70924

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in meiotic cell cycle IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in chromosome IEA
Inferred from Electronic Annotation
more info
  
located_in chromosome ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  
Preferred Names
proline-rich protein 19

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_199285.3 → NP_954979.2  proline-rich protein 19

    See identical proteins and their annotated locations for NP_954979.2

    Status: VALIDATED

    Source sequence(s)
    AK124116, BM762502
    Consensus CDS
    CCDS33036.1
    UniProtKB/Swiss-Prot
    A6NJB7, A8K663, B3KW48, Q6P584
    Related
    ENSP00000342709.3, ENST00000341747.8
    Conserved Domains (1) summary
    pfam15455
    Location:1 → 356
    Pro-rich_19; Proline-rich 19

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2025_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    42302132..42310814
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006723154.4 → XP_006723217.1  proline-rich protein 19 isoform X2

    See identical proteins and their annotated locations for XP_006723217.1

    UniProtKB/Swiss-Prot
    A6NJB7, A8K663, B3KW48, Q6P584
    Related
    ENSP00000586595.1, ENST00000916536.1
    Conserved Domains (1) summary
    pfam15455
    Location:1 → 356
    Pro-rich_19; Proline-rich 19

  2. XM_005258779.5 → XP_005258836.2  proline-rich protein 19 isoform X1

    Conserved Domains (1) summary
    pfam15455
    Location:53 → 408
    Pro-rich_19; Proline-rich 19

  3. XM_011526787.2 → XP_011525089.1  proline-rich protein 19 isoform X2

    See identical proteins and their annotated locations for XP_011525089.1

    UniProtKB/Swiss-Prot
    A6NJB7, A8K663, B3KW48, Q6P584
    Conserved Domains (1) summary
    pfam15455
    Location:1 → 356
    Pro-rich_19; Proline-rich 19

  4. XM_011526790.3 → XP_011525092.1  proline-rich protein 19 isoform X2

    See identical proteins and their annotated locations for XP_011525092.1

    UniProtKB/Swiss-Prot
    A6NJB7, A8K663, B3KW48, Q6P584
    Related
    ENSP00000565044.1, ENST00000894985.1
    Conserved Domains (1) summary
    pfam15455
    Location:1 → 356
    Pro-rich_19; Proline-rich 19

  5. XM_011526788.2 → XP_011525090.1  proline-rich protein 19 isoform X2

    See identical proteins and their annotated locations for XP_011525090.1

    UniProtKB/Swiss-Prot
    A6NJB7, A8K663, B3KW48, Q6P584
    Related
    ENSP00000586596.1, ENST00000916537.1
    Conserved Domains (1) summary
    pfam15455
    Location:1 → 356
    Pro-rich_19; Proline-rich 19

  6. XM_011526789.3 → XP_011525091.1  proline-rich protein 19 isoform X2

    See identical proteins and their annotated locations for XP_011525091.1

    UniProtKB/Swiss-Prot
    A6NJB7, A8K663, B3KW48, Q6P584
    Conserved Domains (1) summary
    pfam15455
    Location:1 → 356
    Pro-rich_19; Proline-rich 19

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    45121505..45130199
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054320622.1 → XP_054176597.1  proline-rich protein 19 isoform X2

    UniProtKB/Swiss-Prot
    A6NJB7, A8K663, B3KW48, Q6P584

  2. XM_054320617.1 → XP_054176592.1  proline-rich protein 19 isoform X1

  3. XM_054320621.1 → XP_054176596.1  proline-rich protein 19 isoform X2

    UniProtKB/Swiss-Prot
    A6NJB7, A8K663, B3KW48, Q6P584

  4. XM_054320619.1 → XP_054176594.1  proline-rich protein 19 isoform X2

    UniProtKB/Swiss-Prot
    A6NJB7, A8K663, B3KW48, Q6P584

  5. XM_054320618.1 → XP_054176593.1  proline-rich protein 19 isoform X2

    UniProtKB/Swiss-Prot
    A6NJB7, A8K663, B3KW48, Q6P584

  6. XM_054320620.1 → XP_054176595.1  proline-rich protein 19 isoform X2

    UniProtKB/Swiss-Prot
    A6NJB7, A8K663, B3KW48, Q6P584
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A6NJB7.1 GenPept UniProtKB/Swiss-Prot:A6NJB7

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