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ZNF780A zinc finger protein 780A [ Homo sapiens (human) ]

Gene ID: 284323, updated on 23-Nov-2021

Summary

Official Symbol
ZNF780Aprovided by HGNC
Official Full Name
zinc finger protein 780Aprovided by HGNC
Primary source
HGNC:HGNC:27603
See related
Ensembl:ENSG00000197782
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ZNF780
Expression
Ubiquitous expression in thyroid (RPKM 2.8), lymph node (RPKM 2.3) and 25 other tissues See more
Orthologs
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Genomic context

See ZNF780A in Genome Data Viewer
Location:
19q13.2
Exon count:
8
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (40069008..40091706, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (40575059..40596850, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene PAT1 homolog 1, processing body mRNA decay factor pseudogene Neighboring gene zinc finger protein 780B Neighboring gene vomeronasal 1 receptor 96 pseudogene Neighboring gene mitogen-activated protein kinase kinase kinase 10

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001010880.3NP_001010880.2  zinc finger protein 780A isoform b

    See identical proteins and their annotated locations for NP_001010880.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and uses an alternate in-frame splice site in the 5' coding region, compared to variant 1, resulting in an isoform (b) that is 1 aa shorter than isoform a. Both variants 2 and 3 encode the same isoform.
    Source sequence(s)
    AC005614, AK091274, BU685481, DA758840, DB097567
    Consensus CDS
    CCDS33026.2
    UniProtKB/Swiss-Prot
    O75290
    Related
    ENSP00000341507.5, ENST00000340963.9
    Conserved Domains (5) summary
    smart00349
    Location:666
    KRAB; krueppel associated box
    COG5048
    Location:219595
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:335355
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:645
    KRAB; KRAB box
    pfam13465
    Location:376400
    zf-H2C2_2; Zinc-finger double domain
  2. NM_001142577.2NP_001136049.1  zinc finger protein 780A isoform a

    See identical proteins and their annotated locations for NP_001136049.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (a).
    Source sequence(s)
    AC005614, AK091274, BC021982, BU685481, DA436454, DA758840
    Consensus CDS
    CCDS46079.1
    UniProtKB/TrEMBL
    Q05CQ7
    Related
    ENSP00000400997.1, ENST00000455521.5
    Conserved Domains (5) summary
    smart00349
    Location:667
    KRAB; krueppel associated box
    COG5048
    Location:220596
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:336356
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:645
    KRAB; KRAB box
    pfam13465
    Location:377401
    zf-H2C2_2; Zinc-finger double domain
  3. NM_001142578.2NP_001136050.1  zinc finger protein 780A isoform b

    See identical proteins and their annotated locations for NP_001136050.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1, resulting in an isoform (b) that is 1 aa shorter than isoform a. Both variants 2 and 3 encode the same isoform.
    Source sequence(s)
    AC005614, AK091274, BC021982, BU685481, DA758840
    Consensus CDS
    CCDS33026.2
    UniProtKB/Swiss-Prot
    O75290
    UniProtKB/TrEMBL
    Q05CQ7
    Related
    ENSP00000506741.1, ENST00000683561.1
    Conserved Domains (5) summary
    smart00349
    Location:666
    KRAB; krueppel associated box
    COG5048
    Location:219595
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:335355
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:645
    KRAB; KRAB box
    pfam13465
    Location:376400
    zf-H2C2_2; Zinc-finger double domain
  4. NM_001142579.2NP_001136051.1  zinc finger protein 780A isoform c

    See identical proteins and their annotated locations for NP_001136051.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR, 3' UTR and 3' coding region, uses an alternate in-frame splice site in its mid coding region, and includes an alternate exon containing a distinct translation start codon, compared to variant 1. The resulting isoform (c) has distinct N- and C-termini, and is shorter than isoform a.
    Source sequence(s)
    AC005614, AI638558, AK131328, AW243188
    Consensus CDS
    CCDS46078.1
    UniProtKB/Swiss-Prot
    O75290
    Related
    ENSP00000416294.1, ENST00000414720.6
    Conserved Domains (2) summary
    smart00349
    Location:2282
    KRAB; krueppel associated box
    pfam01352
    Location:2261
    KRAB; KRAB box

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    40069008..40091706 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006723150.4XP_006723213.1  zinc finger protein 780A isoform X3

    See identical proteins and their annotated locations for XP_006723213.1

    UniProtKB/Swiss-Prot
    O75290
    Conserved Domains (5) summary
    smart00349
    Location:667
    KRAB; krueppel associated box
    COG5048
    Location:220596
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:336356
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:645
    KRAB; KRAB box
    pfam13465
    Location:377401
    zf-H2C2_2; Zinc-finger double domain
  2. XM_024451454.1XP_024307222.1  zinc finger protein 780A isoform X1

    Conserved Domains (4) summary
    smart00349
    Location:2283
    KRAB; krueppel associated box
    COG5048
    Location:236612
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:352372
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:196220
    zf-H2C2_2; Zinc-finger double domain
  3. XM_017026619.2XP_016882108.1  zinc finger protein 780A isoform X4

    UniProtKB/Swiss-Prot
    O75290
    Conserved Domains (5) summary
    smart00349
    Location:666
    KRAB; krueppel associated box
    COG5048
    Location:219595
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:335355
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:645
    KRAB; KRAB box
    pfam13465
    Location:376400
    zf-H2C2_2; Zinc-finger double domain
  4. XM_017026616.2XP_016882105.1  zinc finger protein 780A isoform X2

    Conserved Domains (4) summary
    smart00349
    Location:2282
    KRAB; krueppel associated box
    COG5048
    Location:235611
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:351371
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:195219
    zf-H2C2_2; Zinc-finger double domain
  5. XM_017026618.2XP_016882107.1  zinc finger protein 780A isoform X4

    UniProtKB/Swiss-Prot
    O75290
    Conserved Domains (5) summary
    smart00349
    Location:666
    KRAB; krueppel associated box
    COG5048
    Location:219595
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:335355
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:645
    KRAB; KRAB box
    pfam13465
    Location:376400
    zf-H2C2_2; Zinc-finger double domain
  6. XM_005258773.3XP_005258830.1  zinc finger protein 780A isoform X3

    See identical proteins and their annotated locations for XP_005258830.1

    UniProtKB/Swiss-Prot
    O75290
    Conserved Domains (5) summary
    smart00349
    Location:667
    KRAB; krueppel associated box
    COG5048
    Location:220596
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:336356
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:645
    KRAB; KRAB box
    pfam13465
    Location:377401
    zf-H2C2_2; Zinc-finger double domain
  7. XM_024451457.1XP_024307225.1  zinc finger protein 780A isoform X1

    Conserved Domains (4) summary
    smart00349
    Location:2283
    KRAB; krueppel associated box
    COG5048
    Location:236612
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:352372
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:196220
    zf-H2C2_2; Zinc-finger double domain
  8. XM_024451458.1XP_024307226.1  zinc finger protein 780A isoform X2

    Conserved Domains (4) summary
    smart00349
    Location:2282
    KRAB; krueppel associated box
    COG5048
    Location:235611
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:351371
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:195219
    zf-H2C2_2; Zinc-finger double domain
  9. XM_011526771.3XP_011525073.1  zinc finger protein 780A isoform X3

    See identical proteins and their annotated locations for XP_011525073.1

    UniProtKB/Swiss-Prot
    O75290
    Conserved Domains (5) summary
    smart00349
    Location:667
    KRAB; krueppel associated box
    COG5048
    Location:220596
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:336356
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:645
    KRAB; KRAB box
    pfam13465
    Location:377401
    zf-H2C2_2; Zinc-finger double domain
  10. XM_024451456.1XP_024307224.1  zinc finger protein 780A isoform X1

    Conserved Domains (4) summary
    smart00349
    Location:2283
    KRAB; krueppel associated box
    COG5048
    Location:236612
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:352372
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:196220
    zf-H2C2_2; Zinc-finger double domain
  11. XM_011526772.3XP_011525074.1  zinc finger protein 780A isoform X3

    See identical proteins and their annotated locations for XP_011525074.1

    UniProtKB/Swiss-Prot
    O75290
    Conserved Domains (5) summary
    smart00349
    Location:667
    KRAB; krueppel associated box
    COG5048
    Location:220596
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:336356
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:645
    KRAB; KRAB box
    pfam13465
    Location:377401
    zf-H2C2_2; Zinc-finger double domain
  12. XM_024451455.1XP_024307223.1  zinc finger protein 780A isoform X1

    Conserved Domains (4) summary
    smart00349
    Location:2283
    KRAB; krueppel associated box
    COG5048
    Location:236612
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:352372
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:196220
    zf-H2C2_2; Zinc-finger double domain

Reference GRCh38.p13 PATCHES

Genomic

  1. NW_009646206.1 Reference GRCh38.p13 PATCHES

    Range
    344295..366086 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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