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SMIM21 small integral membrane protein 21 [ Homo sapiens (human) ]

Gene ID: 284274, updated on 22-Sep-2022

Summary

Official Symbol
SMIM21provided by HGNC
Official Full Name
small integral membrane protein 21provided by HGNC
Primary source
HGNC:HGNC:27598
See related
Ensembl:ENSG00000206026 AllianceGenome:HGNC:27598
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
C18orf62
Summary
Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Low expression observed in reference dataset See more
Orthologs
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Genomic context

See SMIM21 in Genome Data Viewer
Location:
18q23
Exon count:
4
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 18 NC_000018.10 (75409476..75427703, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 18 NC_060942.1 (75638773..75656968, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 18 NC_000018.9 (73121431..73139658, complement)

Chromosome 18 - NC_000018.10Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 3936 Neighboring gene prostaglandin reductase 3 Neighboring gene teashirt zinc finger homeobox 1 Neighboring gene uncharacterized LOC105372200 Neighboring gene uncharacterized LOC124900405 Neighboring gene uncharacterized LOC107985177 Neighboring gene uncharacterized LOC105372201

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Phenotypes

EBI GWAS Catalog

Description
A genome-wide association study of rheumatoid arthritis without antibodies against citrullinated peptides.
EBI GWAS Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC126049

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
small integral membrane protein 21

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001037331.3NP_001032408.1  small integral membrane protein 21 isoform1

    See identical proteins and their annotated locations for NP_001032408.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the shorter transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC116003, AK093452
    Consensus CDS
    CCDS32845.1
    UniProtKB/Swiss-Prot
    Q3B7S5
    Related
    ENSP00000462106.1, ENST00000579022.5
  2. NM_001303482.2NP_001290411.1  small integral membrane protein 21 isoform 2

    See identical proteins and their annotated locations for NP_001290411.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate 3' terminal exon compared to variant 1. The encoded isoform (2) is shorter, and contains a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC116003, AK093452, AW118572, BC037871, BX117297
    Consensus CDS
    CCDS77200.1
    UniProtKB/TrEMBL
    J3KSN8
    Related
    ENSP00000462572.1, ENST00000584508.1

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000018.10 Reference GRCh38.p14 Primary Assembly

    Range
    75409476..75427703 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060942.1 Alternate T2T-CHM13v2.0

    Range
    75638773..75656968 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)