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ZADH2 zinc binding alcohol dehydrogenase domain containing 2 [ Homo sapiens (human) ]

Gene ID: 284273, updated on 13-Mar-2020

Summary

Official Symbol
ZADH2provided by HGNC
Official Full Name
zinc binding alcohol dehydrogenase domain containing 2provided by HGNC
Primary source
HGNC:HGNC:28697
See related
Ensembl:ENSG00000180011
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PRG-3
Expression
Ubiquitous expression in placenta (RPKM 7.9), thyroid (RPKM 6.9) and 25 other tissues See more
Orthologs

Genomic context

See ZADH2 in Genome Data Viewer
Location:
18q22.3
Exon count:
3
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 18 NC_000018.10 (75195108..75209506, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 18 NC_000018.9 (72909278..72921281, complement)

Chromosome 18 - NC_000018.10Genomic Context describing neighboring genes Neighboring gene zinc finger protein 407 Neighboring gene uncharacterized LOC107985130 Neighboring gene uncharacterized LOC105376874 Neighboring gene teashirt zinc finger homeobox 1 Neighboring gene uncharacterized LOC105372200 Neighboring gene small integral membrane protein 21

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC45594

Gene Ontology Provided by GOA

Function Evidence Code Pubs
13-prostaglandin reductase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
15-oxoprostaglandin 13-oxidase activity IEA
Inferred from Electronic Annotation
more info
 
molecular_function ND
No biological Data available
more info
 
zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
biological_process ND
No biological Data available
more info
 
negative regulation of fat cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
oxidation-reduction process IEA
Inferred from Electronic Annotation
more info
 
prostaglandin metabolic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
peroxisome ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
prostaglandin reductase 3
Names
zinc-binding alcohol dehydrogenase domain-containing protein 2
NP_001293022.1
NP_787103.1
XP_024306934.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001306093.1NP_001293022.1  prostaglandin reductase 3 isoform 2

    See identical proteins and their annotated locations for NP_001293022.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains an alternate 5' terminal exon, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AC025105, AK302801, BU682476, BX647730
    Consensus CDS
    CCDS77198.1
    UniProtKB/Swiss-Prot
    Q8N4Q0
    Related
    ENSP00000440111.2, ENST00000537114.2
    Conserved Domains (1) summary
    cl16912
    Location:1245
    MDR; Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family
  2. NM_175907.6NP_787103.1  prostaglandin reductase 3 isoform 1

    See identical proteins and their annotated locations for NP_787103.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC025105, BC018081, BU682476
    Consensus CDS
    CCDS12008.1
    UniProtKB/Swiss-Prot
    Q8N4Q0
    UniProtKB/TrEMBL
    Q4G1C4
    Related
    ENSP00000323678.3, ENST00000322342.4
    Conserved Domains (1) summary
    cd08250
    Location:32368
    Mgc45594_like; Mgc45594 gene product and other MDR family members

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000018.10 Reference GRCh38.p13 Primary Assembly

    Range
    75195108..75209506 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024451166.1XP_024306934.1  prostaglandin reductase 3 isoform X1

    Conserved Domains (1) summary
    cl16912
    Location:1245
    MDR; Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family
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