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PTGR3 prostaglandin reductase 3 [ Homo sapiens (human) ]

Gene ID: 284273, updated on 6-Sep-2022

Summary

Official Symbol
PTGR3provided by HGNC
Official Full Name
prostaglandin reductase 3provided by HGNC
Primary source
HGNC:HGNC:28697
See related
Ensembl:ENSG00000180011 AllianceGenome:HGNC:28697
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PRG-3; ZADH2; PTGR-3
Summary
Predicted to enable 13-prostaglandin reductase activity. Predicted to be involved in negative regulation of fat cell differentiation. Predicted to be located in peroxisome. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in placenta (RPKM 7.9), thyroid (RPKM 6.9) and 25 other tissues See more
Orthologs
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Genomic context

See PTGR3 in Genome Data Viewer
Location:
18q22.3
Exon count:
4
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 18 NC_000018.10 (75195108..75209139, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 18 NC_060942.1 (75424502..75438532, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 18 NC_000018.9 (72907063..72921094, complement)

Chromosome 18 - NC_000018.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124904325 Neighboring gene uncharacterized LOC124904326 Neighboring gene uncharacterized LOC105376874 Neighboring gene Sharpr-MPRA regulatory region 3936 Neighboring gene teashirt zinc finger homeobox 1 Neighboring gene uncharacterized LOC105372200 Neighboring gene small integral membrane protein 21

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC45594

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables 13-prostaglandin reductase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables 13-prostaglandin reductase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables 15-oxoprostaglandin 13-oxidase activity IEA
Inferred from Electronic Annotation
more info
 
enables molecular_function ND
No biological Data available
more info
 
enables oxidoreductase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
 
involved_in negative regulation of fat cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in prostaglandin metabolic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in peroxisome ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
prostaglandin reductase 3
Names
zinc binding alcohol dehydrogenase domain containing 2
zinc-binding alcohol dehydrogenase domain-containing protein 2
NP_001293022.1
NP_787103.1
XP_024306934.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001306093.1NP_001293022.1  prostaglandin reductase 3 isoform 2

    See identical proteins and their annotated locations for NP_001293022.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains an alternate 5' terminal exon, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AC025105, AK302801, BU682476, BX647730
    Consensus CDS
    CCDS77198.1
    UniProtKB/Swiss-Prot
    Q8N4Q0
    Related
    ENSP00000440111.2, ENST00000537114.2
    Conserved Domains (1) summary
    cl16912
    Location:1245
    MDR; Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family
  2. NM_175907.6NP_787103.1  prostaglandin reductase 3 isoform 1

    See identical proteins and their annotated locations for NP_787103.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC025105, BC018081, BU682476
    Consensus CDS
    CCDS12008.1
    UniProtKB/Swiss-Prot
    B4DZ91, Q8N4Q0
    UniProtKB/TrEMBL
    Q4G1C4
    Related
    ENSP00000323678.3, ENST00000322342.4
    Conserved Domains (1) summary
    cd08250
    Location:32368
    Mgc45594_like; Mgc45594 gene product and other MDR family members

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000018.10 Reference GRCh38.p14 Primary Assembly

    Range
    75195108..75209139 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024451166.2XP_024306934.1  prostaglandin reductase 3 isoform X1

    Conserved Domains (1) summary
    cl16912
    Location:1245
    MDR; Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060942.1 Alternate T2T-CHM13v2.0

    Range
    75424502..75438532 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)