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SIGLEC15 sialic acid binding Ig like lectin 15 [ Homo sapiens (human) ]

Gene ID: 284266, updated on 13-Feb-2019


Official Symbol
SIGLEC15provided by HGNC
Official Full Name
sialic acid binding Ig like lectin 15provided by HGNC
Primary source
See related
Ensembl:ENSG00000197046 MIM:618105
Gene type
protein coding
RefSeq status
Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CD33L3; HsT1361; SIGLEC-15
Biased expression in small intestine (RPKM 1.8), duodenum (RPKM 1.0) and 8 other tissues See more

Genomic context

See SIGLEC15 in Genome Data Viewer
Exon count:
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 18 NC_000018.10 (45825580..45842556)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 18 NC_000018.9 (43405545..43422521)

Chromosome 18 - NC_000018.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105372093 Neighboring gene uncharacterized LOC105372092 Neighboring gene solute carrier family 14 member 1 (Kidd blood group) Neighboring gene ectopic P-granules autophagy protein 5 homolog Neighboring gene proline-serine-threonine phosphatase interacting protein 2 Neighboring gene RN7SK pseudogene 26 Neighboring gene UTP18, small subunit (SSU) processome component, homolog (yeast) pseudogene

Genomic regions, transcripts, and products


  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018


GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

  • DAP12 interactions, organism-specific biosystem (from REACTOME)
    DAP12 interactions, organism-specific biosystemDNAX activation protein of 12kDa (DAP12) is an immunoreceptor tyrosine-based activation motif (ITAM)-bearing adapter molecule that transduces activating signals in natural killer (NK) and myeloid cel...
  • Immune System, organism-specific biosystem (from REACTOME)
    Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
  • Innate Immune System, organism-specific biosystem (from REACTOME)
    Innate Immune System, organism-specific biosystemInnate immunity encompases the nonspecific part of immunity tha are part of an individual's natural biologic makeup

General gene information



Gene Ontology Provided by GOA

Process Evidence Code Pubs
innate immune response TAS
Traceable Author Statement
more info
regulation of actin cytoskeleton organization IEA
Inferred from Electronic Annotation
more info
regulation of bone resorption IEA
Inferred from Electronic Annotation
more info
regulation of osteoclast development IEA
Inferred from Electronic Annotation
more info
Component Evidence Code Pubs
integral component of membrane IEA
Inferred from Electronic Annotation
more info
plasma membrane TAS
Traceable Author Statement
more info
protein-containing complex IEA
Inferred from Electronic Annotation
more info

General protein information

Preferred Names
sialic acid-binding Ig-like lectin 15
CD33 antigen-like 3
CD33 molecule-like 3

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_213602.2NP_998767.1  sialic acid-binding Ig-like lectin 15 precursor

    See identical proteins and their annotated locations for NP_998767.1

    Status: VALIDATED

    Source sequence(s)
    AK172835, DC299128
    Consensus CDS
    ENSP00000374125.2, ENST00000389474.7
    Conserved Domains (1) summary
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly


  1. NC_000018.10 Reference GRCh38.p12 Primary Assembly

    GenBank, FASTA, Sequence Viewer (Graphics)
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