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GPR19 G protein-coupled receptor 19 [ Homo sapiens (human) ]

Gene ID: 2842, updated on 13-Mar-2020

Summary

Official Symbol
GPR19provided by HGNC
Official Full Name
G protein-coupled receptor 19provided by HGNC
Primary source
HGNC:HGNC:4473
See related
Ensembl:ENSG00000183150 MIM:602927
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Low expression observed in reference dataset See more
Orthologs

Genomic context

See GPR19 in Genome Data Viewer
Location:
12p13.1
Exon count:
8
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 12 NC_000012.12 (12659691..12717786, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (12813995..12849121, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107984486 Neighboring gene ribosomal protein L21 pseudogene 136 Neighboring gene cAMP responsive element binding protein like 2 Neighboring gene uncharacterized LOC105369663 Neighboring gene uncharacterized LOC107984129 Neighboring gene cyclin dependent kinase inhibitor 1B Neighboring gene apolipoprotein L domain containing 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Meta-analysis followed by replication identifies loci in or near CDKN1B, TET3, CD80, DRAM1, and ARID5B as associated with systemic lupus erythematosus in Asians.
NHGRI GWA Catalog

Pathways from PubChem

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cilium IDA
Inferred from Direct Assay
more info
PubMed 
integral component of plasma membrane TAS
Traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
probable G-protein coupled receptor 19
Names
GPR-NGA

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_006143.3NP_006134.2  probable G-protein coupled receptor 19

    Status: VALIDATED

    Source sequence(s)
    AC008115
    Consensus CDS
    CCDS8652.1
    Related
    ENSP00000498976.1, ENST00000651487.1
    Conserved Domains (1) summary
    cd15008
    Location:67341
    7tmA_GPR19; G protein-coupled receptor 19, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p13 Primary Assembly

    Range
    12659691..12717786 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017019216.2XP_016874705.1  probable G-protein coupled receptor 19 isoform X2

    UniProtKB/Swiss-Prot
    Q15760
    Conserved Domains (1) summary
    cd15008
    Location:67341
    7tmA_GPR19; G protein-coupled receptor 19, member of the class A family of seven-transmembrane G protein-coupled receptors
  2. XM_011520623.3XP_011518925.1  probable G-protein coupled receptor 19 isoform X1

    See identical proteins and their annotated locations for XP_011518925.1

    Conserved Domains (2) summary
    pfam00001
    Location:101349
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:91277
    7tm_4; Olfactory receptor
  3. XM_011520624.2XP_011518926.1  probable G-protein coupled receptor 19 isoform X1

    See identical proteins and their annotated locations for XP_011518926.1

    Conserved Domains (2) summary
    pfam00001
    Location:101349
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:91277
    7tm_4; Olfactory receptor
  4. XM_017019212.1XP_016874701.1  probable G-protein coupled receptor 19 isoform X1

    Conserved Domains (2) summary
    pfam00001
    Location:101349
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:91277
    7tm_4; Olfactory receptor
  5. XM_011520625.2XP_011518927.1  probable G-protein coupled receptor 19 isoform X2

    See identical proteins and their annotated locations for XP_011518927.1

    UniProtKB/Swiss-Prot
    Q15760
    Conserved Domains (1) summary
    cd15008
    Location:67341
    7tmA_GPR19; G protein-coupled receptor 19, member of the class A family of seven-transmembrane G protein-coupled receptors
  6. XM_017019213.1XP_016874702.1  probable G-protein coupled receptor 19 isoform X1

    Conserved Domains (2) summary
    pfam00001
    Location:101349
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:91277
    7tm_4; Olfactory receptor
  7. XM_017019214.1XP_016874703.1  probable G-protein coupled receptor 19 isoform X1

    Conserved Domains (2) summary
    pfam00001
    Location:101349
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:91277
    7tm_4; Olfactory receptor
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