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LGALS9B galectin 9B [ Homo sapiens (human) ]

Gene ID: 284194, updated on 8-Jul-2019

Summary

Official Symbol
LGALS9Bprovided by HGNC
Official Full Name
galectin 9Bprovided by HGNC
Primary source
HGNC:HGNC:24842
See related
Ensembl:ENSG00000170298
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This gene was initially thought to represent a pseudogene of galectin 9; however, this transcript has good exon-intron structure and encodes a predicted protein of the same size as and highly similar to galectin 9. This gene is one of two similar loci on chromosome 17p similar to galectin 9 and now thought to be protein-encoding. This gene is the more centromeric gene. [provided by RefSeq, Jul 2008]
Expression
Biased expression in stomach (RPKM 25.2), gall bladder (RPKM 10.0) and 4 other tissues See more
Orthologs

Genomic context

See LGALS9B in Genome Data Viewer
Location:
17p11.2
Exon count:
11
Annotation release Status Assembly Chr Location
109.20190607 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (20449395..20467535, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (20352708..20370848, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene ubiquitin specific peptidase 32 pseudogene 3 Neighboring gene family with sequence similarity 106 member B Neighboring gene proximal SMS-REP block A recombination region Neighboring gene nitric oxide synthase 2 pseudogene 3 Neighboring gene transportin 1 pseudogene 3 Neighboring gene tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon pseudogene 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ58146, FLJ75081

Gene Ontology Provided by GOA

Function Evidence Code Pubs
carbohydrate binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
galactoside binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
negative regulation of CD4-positive, alpha-beta T cell proliferation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of gene expression IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of interferon-gamma production IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of gene expression IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of interleukin-10 secretion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of interleukin-6 secretion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
galectin-9B
Names
gal-9B
galectin-9 like
galectin-9 pseudogene
galectin-9-like protein A
lectin, galactoside-binding, soluble, 9B

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001042685.2NP_001036150.1  galectin-9B isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC015818
    Consensus CDS
    CCDS42283.1
    UniProtKB/Swiss-Prot
    Q3B8N2
    Related
    ENSP00000315564.5, ENST00000324290.5
    Conserved Domains (2) summary
    smart00908
    Location:232354
    Gal-bind_lectin; Galactoside-binding lectin
    cd00070
    Location:16146
    GLECT; Galectin/galactose-binding lectin. This domain exclusively binds beta-galactosides, such as lactose, and does not require metal ions for activity. GLECT domains occur as homodimers or tandemly repeated domains. They are developmentally regulated and may ...
  2. NM_001367292.1NP_001354221.1  galectin-9B isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC015818
    Related
    ENSP00000388841.3, ENST00000423676.7
    Conserved Domains (3) summary
    smart00908
    Location:233355
    Gal-bind_lectin; Galactoside-binding lectin
    cd00070
    Location:16146
    GLECT; Galectin/galactose-binding lectin. This domain exclusively binds beta-galactosides, such as lactose, and does not require metal ions for activity. GLECT domains occur as homodimers or tandemly repeated domains. They are developmentally regulated and may ...
    cl26386
    Location:150227
    DNA_pol3_gamma3; DNA polymerase III subunits gamma and tau domain III

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    20449395..20467535 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NG_002718.1: Suppressed sequence

    Description
    NG_002718.1: This RefSeq was permanently suppressed because it is now thought that this gene does encode a protein.
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