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TMEM102 transmembrane protein 102 [ Homo sapiens (human) ]

Gene ID: 284114, updated on 6-Nov-2022

Summary

Official Symbol
TMEM102provided by HGNC
Official Full Name
transmembrane protein 102provided by HGNC
Primary source
HGNC:HGNC:26722
See related
Ensembl:ENSG00000181284 MIM:613936; AllianceGenome:HGNC:26722
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CBAP
Summary
Involved in regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway; response to cytokine; and signal transduction. Acts upstream of or within positive regulation of T cell migration and positive regulation of cell adhesion. Located in cell surface. Part of protein-containing complex. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in colon (RPKM 3.0), adrenal (RPKM 2.7) and 24 other tissues See more
Orthologs
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Genomic context

See TMEM102 in Genome Data Viewer
Location:
17p13.1
Exon count:
3
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (7435435..7437679)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (7339490..7341734)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (7338754..7340998)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene SPEM family member 2 Neighboring gene SPEM family member 3 Neighboring gene fibroblast growth factor 11 Neighboring gene cholinergic receptor nicotinic beta 1 subunit

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ36878

General protein information

Preferred Names
transmembrane protein 102
Names
common beta-chain associated protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001320444.1NP_001307373.1  transmembrane protein 102

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC113189
    Consensus CDS
    CCDS11104.1
    UniProtKB/Swiss-Prot
    D3DTP8, Q8N9M5
    Related
    ENSP00000379815.1, ENST00000396568.1
    Conserved Domains (1) summary
    pfam03281
    Location:317455
    Mab-21; Mab-21 protein
  2. NM_178518.3NP_848613.1  transmembrane protein 102

    See identical proteins and their annotated locations for NP_848613.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC113189, BC046189
    Consensus CDS
    CCDS11104.1
    UniProtKB/Swiss-Prot
    D3DTP8, Q8N9M5
    Related
    ENSP00000315387.1, ENST00000323206.2
    Conserved Domains (1) summary
    pfam03281
    Location:317455
    Mab-21; Mab-21 protein

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

    Range
    7435435..7437679
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 PATCHES

Genomic

  1. NW_016107299.1 Reference GRCh38.p14 PATCHES

    Range
    55892..58136
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060941.1 Alternate T2T-CHM13v2.0

    Range
    7339490..7341734
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)