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CISD3 CDGSH iron sulfur domain 3 [ Homo sapiens (human) ]

Gene ID: 284106, updated on 11-Jun-2021

Summary

Official Symbol
CISD3provided by HGNC
Official Full Name
CDGSH iron sulfur domain 3provided by HGNC
Primary source
HGNC:HGNC:27578
See related
Ensembl:ENSG00000277972 MIM:611933
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MiNT; Miner2
Summary
CISD3 is a member of the CDGSH domain-containing family, which may play a role in regulating electron transport and oxidative phosphorylation (Wiley et al., 2007 [PubMed 17376863]).[supplied by OMIM, Apr 2008]
Expression
Ubiquitous expression in kidney (RPKM 15.7), small intestine (RPKM 14.3) and 25 other tissues See more
Orthologs
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Genomic context

See CISD3 in Genome Data Viewer
Location:
17q12
Exon count:
4
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (38730341..38735605)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (36886594..36891858)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene MLLT6, PHD finger containing Neighboring gene uncharacterized LOC105371762 Neighboring gene microRNA 4726 Neighboring gene control region 19 heart enhancer Neighboring gene RNA, 5S ribosomal pseudogene 440 Neighboring gene polycomb group ring finger 2 Neighboring gene uncharacterized LOC100287808 Neighboring gene tRNA-Asn (anticodon GTT) 2-5

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables 2 iron, 2 sulfur cluster binding IDA
Inferred from Direct Assay
more info
PubMed 
enables metal ion binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in protein maturation by [2Fe-2S] cluster transfer IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
CDGSH iron-sulfur domain-containing protein 3, mitochondrial
Names
mitoNEET related 2
mitoNEET-related protein 2
mitochondrial inner NEET protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001136498.2NP_001129970.1  CDGSH iron-sulfur domain-containing protein 3, mitochondrial precursor

    See identical proteins and their annotated locations for NP_001129970.1

    Status: VALIDATED

    Source sequence(s)
    AC006449
    Consensus CDS
    CCDS45662.1
    UniProtKB/Swiss-Prot
    P0C7P0
    Related
    ENSP00000483781.1, ENST00000613478.2
    Conserved Domains (2) summary
    smart00704
    Location:4475
    ZnF_CDGSH; CDGSH-type zinc finger. Function unknown
    cl02748
    Location:83119
    zf-CDGSH; Iron-binding zinc finger CDGSH type

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    38730341..38735605
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p13 ALT_REF_LOCI_1

Genomic

  1. NT_187614.1 Reference GRCh38.p13 ALT_REF_LOCI_1

    Range
    2765660..2770924
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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