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NEK8 NIMA related kinase 8 [ Homo sapiens (human) ]

Gene ID: 284086, updated on 16-May-2021

Summary

Official Symbol
NEK8provided by HGNC
Official Full Name
NIMA related kinase 8provided by HGNC
Primary source
HGNC:HGNC:13387
See related
Ensembl:ENSG00000160602 MIM:609799
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
JCK; NPHP9; RHPD2; NEK12A
Summary
This gene encodes a member of the serine/threionine protein kinase family related to NIMA (never in mitosis, gene A) of Aspergillus nidulans. The encoded protein may play a role in cell cycle progression from G2 to M phase. Mutations in the related mouse gene are associated with a disease phenotype that closely parallels the juvenile autosomal recessive form of polycystic kidney disease in humans. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in thyroid (RPKM 2.8), lymph node (RPKM 2.5) and 25 other tissues See more
Orthologs
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Genomic context

See NEK8 in Genome Data Viewer
Location:
17q11.2
Exon count:
15
Annotation release Status Assembly Chr Location
109.20210226 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (28728788..28743455)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (27055806..27070473)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene ribosomal protein L23a Neighboring gene small nucleolar RNA, C/D box 4B Neighboring gene TLC domain containing 1 Neighboring gene Sharpr-MPRA regulatory region 11843 Neighboring gene TNF receptor associated factor 4 Neighboring gene family with sequence similarity 222 member B Neighboring gene ribosomal protein L31 pseudogene 58

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC138445

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in animal organ morphogenesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in animal organ morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in chromosome segregation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in determination of left/right symmetry IEA
Inferred from Electronic Annotation
more info
 
involved_in heart development IEA
Inferred from Electronic Annotation
more info
 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of hippo signaling IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
is_active_in centrosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in ciliary base IEA
Inferred from Electronic Annotation
more info
 
located_in ciliary inversin compartment IEA
Inferred from Electronic Annotation
more info
 
is_active_in cilium IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cilium IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in cilium ISS
Inferred from Sequence or Structural Similarity
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
serine/threonine-protein kinase Nek8
Names
NIMA (never in mitosis gene a)- related kinase 8
NIMA-family kinase NEK8
NIMA-related kinase 12a
nephrocystin 9
never in mitosis A-related kinase 8
nimA-related protein kinase 8
nima-related protein kinase 12a
serine/thrionine-protein kinase NEK8
NP_835464.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_012263.1 RefSeqGene

    Range
    4975..19642
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_178170.3NP_835464.1  serine/threonine-protein kinase Nek8

    See identical proteins and their annotated locations for NP_835464.1

    Status: REVIEWED

    Source sequence(s)
    AC010761, AY242354, CV811826
    Consensus CDS
    CCDS32597.1
    UniProtKB/Swiss-Prot
    Q86SG6
    Related
    ENSP00000268766.6, ENST00000268766.11
    Conserved Domains (2) summary
    cd08220
    Location:3258
    STKc_Nek8; Catalytic domain of the Protein Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 8
    cl27697
    Location:276657
    RCC1; Regulator of chromosome condensation (RCC1) repeat

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210226

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    28728788..28743455
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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