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TTLL6 tubulin tyrosine ligase like 6 [ Homo sapiens (human) ]

Gene ID: 284076, updated on 25-Nov-2021

Summary

Official Symbol
TTLL6provided by HGNC
Official Full Name
tubulin tyrosine ligase like 6provided by HGNC
Primary source
HGNC:HGNC:26664
See related
Ensembl:ENSG00000170703 MIM:610849
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TTL.6
Expression
Biased expression in testis (RPKM 10.4), colon (RPKM 1.9) and 5 other tissues See more
Orthologs
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Genomic context

See TTLL6 in Genome Data Viewer
Location:
17q21.32
Exon count:
19
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (48762234..48817247, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (46839596..46894591, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105371811 Neighboring gene uncharacterized LOC105371812 Neighboring gene RNA, 7SL, cytoplasmic 125, pseudogene Neighboring gene uncharacterized LOC105371813 Neighboring gene calcium binding and coiled-coil domain 2 Neighboring gene uncharacterized LOC105371814 Neighboring gene SUMO2 pseudogene 17

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Phenotypes

Associated conditions

Description Tests
Polygenic dissection of diagnosis and clinical dimensions of bipolar disorder and schizophrenia.
GeneReviews: Not available

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ35808

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein-glutamic acid ligase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables tubulin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables tubulin binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables tubulin-glutamic acid ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables tubulin-glutamic acid ligase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables tubulin-glutamic acid ligase activity TAS
Traceable Author Statement
more info
 
Process Evidence Code Pubs
involved_in microtubule bundle formation IEA
Inferred from Electronic Annotation
more info
 
involved_in microtubule cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in microtubule severing IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of cilium movement IEA
Inferred from Electronic Annotation
more info
 
involved_in protein polyglutamylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in protein polyglutamylation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in protein polyglutamylation TAS
Traceable Author Statement
more info
 
involved_in regulation of cilium beat frequency involved in ciliary motility ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
located_in 9+0 non-motile cilium IEA
Inferred from Electronic Annotation
more info
 
located_in ciliary basal body IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in cilium IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in microtubule IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
tubulin polyglutamylase TTLL6
Names
protein polyglutamylase TTLL6
tubulin tyrosine ligase-like family member 6
tubulin--tyrosine ligase-like protein 6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001130918.3NP_001124390.1  tubulin polyglutamylase TTLL6 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC068531, AK302952
    Consensus CDS
    CCDS45724.1
    UniProtKB/Swiss-Prot
    Q8N841
    Related
    ENSP00000377043.3, ENST00000393382.8
    Conserved Domains (1) summary
    pfam03133
    Location:154441
    TTL; Tubulin-tyrosine ligase family
  2. NM_001366314.2NP_001353243.1  tubulin polyglutamylase TTLL6 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC068531
    Conserved Domains (1) summary
    pfam03133
    Location:1281
    TTL; Tubulin-tyrosine ligase family
  3. NM_173623.4NP_775894.2  tubulin polyglutamylase TTLL6 isoform 2

    See identical proteins and their annotated locations for NP_775894.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains a distinct 5' UTR and lacks an in-frame portion of the 5' coding region, compared to variant 1. The resulting isoform (2) has a shorter N-terminus when compared to isoform 1.
    Source sequence(s)
    AC068531, BC033563
    Consensus CDS
    CCDS11537.2
    UniProtKB/Swiss-Prot
    Q8N841
    Related
    ENSP00000399211.2, ENST00000433608.6
    Conserved Domains (1) summary
    cl17255
    Location:27134
    ATP-grasp_4; ATP-grasp domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    48762234..48817247 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017024491.2XP_016879980.1  tubulin polyglutamylase TTLL6 isoform X1

  2. XM_017024494.2XP_016879983.1  tubulin polyglutamylase TTLL6 isoform X2

  3. XM_017024493.2XP_016879982.1  tubulin polyglutamylase TTLL6 isoform X2

  4. XM_017024495.2XP_016879984.1  tubulin polyglutamylase TTLL6 isoform X3

    UniProtKB/TrEMBL
    D3DTW0
    Related
    ENST00000490027.5
    Conserved Domains (1) summary
    cl17255
    Location:2187
    ATP-grasp_4; ATP-grasp domain
  5. XM_017024492.1XP_016879981.1  tubulin polyglutamylase TTLL6 isoform X2

  6. XM_017024496.1XP_016879985.1  tubulin polyglutamylase TTLL6 isoform X4

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