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MILR1 mast cell immunoglobulin like receptor 1 [ Homo sapiens (human) ]

Gene ID: 284021, updated on 18-Aug-2020

Summary

Official Symbol
MILR1provided by HGNC
Official Full Name
mast cell immunoglobulin like receptor 1provided by HGNC
Primary source
HGNC:HGNC:27570
See related
Ensembl:ENSG00000271605
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MCA32; MCA-32; C17orf60; Allergin-1
Expression
Broad expression in appendix (RPKM 7.6), lymph node (RPKM 6.4) and 21 other tissues See more
Orthologs

Genomic context

See MILR1 in Genome Data Viewer
Location:
17q23.3
Exon count:
16
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (64449006..64496469)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (62461567..62464760)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene ribosomal protein L31 pseudogene 57 Neighboring gene platelet and endothelial cell adhesion molecule 1 Neighboring gene DNA polymerase gamma 2, accessory subunit Neighboring gene ATP synthase membrane subunit f pseudogene 4 Neighboring gene microRNA 3064 Neighboring gene microRNA 5047 Neighboring gene DEAD-box helicase 5

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC163278

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
transmembrane signaling receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
cell surface receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cell-cell adhesion via plasma-membrane adhesion molecules IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mast cell degranulation ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of mast cell activation ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
integral component of plasma membrane NAS
Non-traceable Author Statement
more info
PubMed 
mast cell granule IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
allergin-1
Names
allergy inhibitory receptor 1
mast cell antigen 32
probable mast cell antigen 32 homolog

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001085423.2NP_001078892.1  allergin-1 isoform Allergin-1L precursor

    See identical proteins and their annotated locations for NP_001078892.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (L) represents the longest transcript and encodes the longest isoform (Allergin-1L, also known as long form).
    Source sequence(s)
    BC053534, BE296352, CD687595
    Consensus CDS
    CCDS74133.1
    UniProtKB/Swiss-Prot
    Q7Z6M3
    Related
    ENSP00000482801.1, ENST00000619286.5
    Conserved Domains (2) summary
    pfam13895
    Location:37121
    Ig_2; Immunoglobulin domain
    pfam13927
    Location:128200
    Ig_3; Immunoglobulin domain
  2. NM_001291316.2NP_001278245.1  allergin-1 isoform Allergin-1S1 precursor

    See identical proteins and their annotated locations for NP_001278245.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (S1) lacks an alternate in-frame exon in the central coding region, compared to variant L, resulting in an isoform (Allergin-1S1, also known as short form 1) that is shorter than isoform Allergin-1L.
    Source sequence(s)
    AC234063
    Consensus CDS
    CCDS77087.1
    UniProtKB/Swiss-Prot
    Q7Z6M3
    Related
    ENSP00000481318.1, ENST00000616498.4
    Conserved Domains (1) summary
    pfam13895
    Location:37121
    Ig_2; Immunoglobulin domain
  3. NM_001291317.2NP_001278246.1  allergin-1 isoform Allergin-1S2 precursor

    See identical proteins and their annotated locations for NP_001278246.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (S2) lacks an alternate in-frame exon in the 5' coding region, compared to variant L, resulting in an isoform (Allergin-1S2, also known as short form 2) that is shorter than isoform Allergin-1L.
    Source sequence(s)
    AC234063
    Consensus CDS
    CCDS77088.1
    UniProtKB/Swiss-Prot
    Q7Z6M3
    Related
    ENSP00000477504.1, ENST00000612535.4
    Conserved Domains (1) summary
    pfam13927
    Location:38110
    Ig_3; Immunoglobulin domain
  4. NM_001369493.1NP_001356422.1  allergin-1 isoform Allergin-1L precursor

    Status: VALIDATED

    Source sequence(s)
    AC234063

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    64449006..64496469
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024450706.1XP_024306474.1  allergin-1 isoform X1

  2. XM_024450708.1XP_024306476.1  allergin-1 isoform X1

  3. XM_024450709.1XP_024306477.1  allergin-1 isoform X1

    Related
    ENSP00000480749.1, ENST00000615220.4
  4. XM_024450707.1XP_024306475.1  allergin-1 isoform X1

  5. XM_017024487.1XP_016879976.1  allergin-1 isoform X2

    Conserved Domains (1) summary
    pfam13927
    Location:70142
    Ig_3; Immunoglobulin domain

RNA

  1. XR_002957990.1 RNA Sequence

  2. XR_002957989.1 RNA Sequence

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