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C17orf58 chromosome 17 open reading frame 58 [ Homo sapiens (human) ]

Gene ID: 284018, updated on 11-Jun-2021

Summary

Official Symbol
C17orf58provided by HGNC
Official Full Name
chromosome 17 open reading frame 58provided by HGNC
Primary source
HGNC:HGNC:27568
See related
Ensembl:ENSG00000186665
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Ubiquitous expression in placenta (RPKM 15.6), endometrium (RPKM 14.5) and 24 other tissues See more
Orthologs
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Genomic context

See C17orf58 in Genome Data Viewer
Location:
17q24.2
Exon count:
4
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (67991099..67996469, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (65987215..65992585, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene ribosomal protein L17 pseudogene 41 Neighboring gene bromodomain PHD finger transcription factor Neighboring gene RNA, 7SL, cytoplasmic 622, pseudogene Neighboring gene tRNA-Arg (anticodon CCG) 2-1 Neighboring gene karyopherin subunit alpha 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

General gene information

Markers

Homology

Clone Names

  • MGC138278

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001382359.1NP_001369288.1  UPF0450 protein C17orf58 isoform c precursor

    Status: VALIDATED

    Source sequence(s)
    AC134407
    Related
    ENSP00000489720.1, ENST00000580729.3
    Conserved Domains (2) summary
    PRK07764
    Location:14205
    PRK07764; DNA polymerase III subunits gamma and tau; Validated
    cl02512
    Location:188317
    NTR_like; NTR_like domain; a beta barrel with an oligosaccharide/oligonucleotide-binding fold found in netrins, complement proteins, tissue inhibitors of metalloproteases (TIMP), and procollagen C-proteinase enhancers (PCOLCE), amongst others. In netrins, the ...
  2. NM_181655.4NP_858041.2  UPF0450 protein C17orf58 isoform a

    See identical proteins and their annotated locations for NP_858041.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (a).
    Source sequence(s)
    AI126153, AK026583, BC036760, BX364842
    Consensus CDS
    CCDS45765.1
    UniProtKB/Swiss-Prot
    Q2M2W7
    Related
    ENSP00000402020.2, ENST00000449250.3
    Conserved Domains (1) summary
    cl02512
    Location:175
    NTR_like; NTR_like domain; a beta barrel with an oligosaccharide/oligonucleotide-binding fold found in netrins, complement proteins, tissue inhibitors of metalloproteases (TIMP), and procollagen C-proteinase enhancers (PCOLCE), amongst others. In netrins, the ...
  3. NM_181656.5NP_858042.2  UPF0450 protein C17orf58 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in the 5' coding region resulting in novel 3' coding region and 3' UTR. It encodes isoform b, which is shorter and has a distinct C-terminus, compared to isoform a.
    Source sequence(s)
    AC134407, AI126153, AK026583, BX364842
    Consensus CDS
    CCDS42375.1
    UniProtKB/Swiss-Prot
    Q2M2W7
    Related
    ENSP00000334741.7, ENST00000334461.7
    Conserved Domains (1) summary
    cl02512
    Location:135
    NTR_like; NTR_like domain; a beta barrel with an oligosaccharide/oligonucleotide-binding fold found in netrins, complement proteins, tissue inhibitors of metalloproteases (TIMP), and procollagen C-proteinase enhancers (PCOLCE), amongst others. In netrins, the ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    67991099..67996469 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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