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TMEM235 transmembrane protein 235 [ Homo sapiens (human) ]

Gene ID: 283999, updated on 26-Oct-2022

Summary

Official Symbol
TMEM235provided by HGNC
Official Full Name
transmembrane protein 235provided by HGNC
Primary source
HGNC:HGNC:27563
See related
Ensembl:ENSG00000204278 AllianceGenome:HGNC:27563
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ARGM1
Summary
Predicted to be located in cytoplasm. Predicted to be active in apical plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward brain (RPKM 1.9) See more
Orthologs
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Genomic context

See TMEM235 in Genome Data Viewer
Location:
17q25.3
Exon count:
10
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (78231293..78240987)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (79125384..79135078)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (76227374..76237068)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene arylformamidase Neighboring gene baculoviral IAP repeat containing 5 Neighboring gene uncharacterized LOC105371910 Neighboring gene threonine aldolase 1, pseudogene Neighboring gene CRISPRi-validated cis-regulatory element chr17.5434

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Component Evidence Code Pubs
is_active_in apical plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
transmembrane protein 235
Names
transmembrane protein ENSP00000364084

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001204210.2NP_001191139.1  transmembrane protein 235 isoform 1 precursor

    See identical proteins and their annotated locations for NP_001191139.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC087645, BC042066, BI757060, BI757981
    Consensus CDS
    CCDS56046.1
    UniProtKB/Swiss-Prot
    A6NFC5, C9JRE6
    Conserved Domains (1) summary
    pfam13903
    Location:28197
    Claudin_2; PMP-22/EMP/MP20/Claudin tight junction
  2. NM_001204211.2NP_001191140.1  transmembrane protein 235 isoform 2 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region, compared to variant 1, resulting in an isoform (2) that is shorter than isoform 1.
    Source sequence(s)
    AC087645, BC036810, BC042066
    Consensus CDS
    CCDS56047.1
    UniProtKB/Swiss-Prot
    A6NFC5
    Related
    ENSP00000447766.3, ENST00000550981.7
    Conserved Domains (1) summary
    cl21598
    Location:28170
    PMP22_Claudin; PMP-22/EMP/MP20/Claudin family
  3. NM_001204212.2NP_001191141.1  transmembrane protein 235 isoform 3 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks two alternate in-frame exons in the 5' coding region, compared to variant 1, resulting in an isoform (3) that is shorter than isoform 1
    Source sequence(s)
    AC087645, BC042066
    Consensus CDS
    CCDS56048.1
    UniProtKB/Swiss-Prot
    A6NFC5
    Related
    ENSP00000466793.1, ENST00000586400.5
    Conserved Domains (1) summary
    cl21598
    Location:64124
    PMP22_Claudin; PMP-22/EMP/MP20/Claudin family
  4. NM_001388480.1NP_001375409.1  transmembrane protein 235 isoform 4 precursor

    Status: VALIDATED

    Source sequence(s)
    AC087645
    Conserved Domains (1) summary
    pfam13903
    Location:28250
    Claudin_2; PMP-22/EMP/MP20/Claudin tight junction
  5. NM_001388481.1NP_001375410.1  transmembrane protein 235 isoform 5 precursor

    Status: VALIDATED

    Source sequence(s)
    AC087645
    Consensus CDS
    CCDS92405.1
    Related
    ENSP00000513303.1, ENST00000697415.1
    Conserved Domains (1) summary
    cl21598
    Location:28296
    PMP22_Claudin; PMP-22/EMP/MP20/Claudin family
  6. NM_001395503.1NP_001382432.1  transmembrane protein 235 isoform 1 precursor

    Status: VALIDATED

    Source sequence(s)
    AC087645
    Consensus CDS
    CCDS56046.1
    UniProtKB/Swiss-Prot
    C9JRE6
    Related
    ENSP00000402790.2, ENST00000421688.7
    Conserved Domains (1) summary
    pfam13903
    Location:28197
    Claudin_2; PMP-22/EMP/MP20/Claudin tight junction

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

    Range
    78231293..78240987
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047435762.1XP_047291718.1  transmembrane protein 235 isoform X2

  2. XM_011524620.3XP_011522922.1  transmembrane protein 235 isoform X1

    Conserved Domains (1) summary
    cl21598
    Location:28251
    PMP22_Claudin; PMP-22/EMP/MP20/Claudin family
  3. XM_047435763.1XP_047291719.1  transmembrane protein 235 isoform X4

  4. XM_017024459.2XP_016879948.1  transmembrane protein 235 isoform X3

  5. XM_047435764.1XP_047291720.1  transmembrane protein 235 isoform X5

  6. XM_017024461.2XP_016879950.1  transmembrane protein 235 isoform X5

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060941.1 Alternate T2T-CHM13v2.0

    Range
    79125384..79135078
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001145529.1: Suppressed sequence

    Description
    NM_001145529.1: This RefSeq was permanently suppressed because currently there is support for the transcript but not for the protein.