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NUDT7 nudix hydrolase 7 [ Homo sapiens (human) ]

Gene ID: 283927, updated on 21-Dec-2019

Summary

Official Symbol
NUDT7provided by HGNC
Official Full Name
nudix hydrolase 7provided by HGNC
Primary source
HGNC:HGNC:8054
See related
Ensembl:ENSG00000140876 MIM:609231
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
The protein encoded by this gene is a member of the Nudix hydrolase family. Nudix hydrolases eliminate potentially toxic nucleotide metabolites from the cell and regulate the concentrations and availability of many different nucleotide substrates, cofactors, and signaling molecules. Alternatively spliced transcript variants encoding multiple isoforms have been found for this gene. [provided by RefSeq, Aug 2011]
Expression
Ubiquitous expression in liver (RPKM 10.5), heart (RPKM 9.9) and 24 other tissues See more
Orthologs

Genomic context

See NUDT7 in Genome Data Viewer
Location:
16q23.1
Exon count:
6
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 16 NC_000016.10 (77722492..77742260)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (77756389..77809332)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105376775 Neighboring gene long intergenic non-protein coding RNA 2131 Neighboring gene Sharpr-MPRA regulatory region 41 Neighboring gene uncharacterized LOC107984878 Neighboring gene vesicle amine transport 1 like Neighboring gene uncharacterized LOC105371351

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Phenotypes

NHGRI GWAS Catalog

Description
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
NHGRI GWA Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
CoA hydrolase activity TAS
Traceable Author Statement
more info
 
acetyl-CoA hydrolase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acetyl-CoA hydrolase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
NOT m7G(5')pppN diphosphatase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
magnesium ion binding IEA
Inferred from Electronic Annotation
more info
 
manganese ion binding IEA
Inferred from Electronic Annotation
more info
 
molecular_function ND
No biological Data available
more info
 
snoRNA binding ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
acetyl-CoA catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
biological_process ND
No biological Data available
more info
 
brown fat cell differentiation IEA
Inferred from Electronic Annotation
more info
 
coenzyme A catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
coenzyme A catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
fatty acid catabolic process TAS
Traceable Author Statement
more info
 
nucleoside diphosphate metabolic process IEA
Inferred from Electronic Annotation
more info
 
protein targeting to peroxisome TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
cytosol TAS
Traceable Author Statement
more info
 
peroxisomal matrix TAS
Traceable Author Statement
more info
 
peroxisome ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
peroxisomal coenzyme A diphosphatase NUDT7
Names
nudix (nucleoside diphosphate linked moiety X)-type motif 7
NP_001099133.1
NP_001230586.1
NP_001230589.1
NP_001230590.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_028059.1 RefSeqGene

    Range
    5001..24747
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001105663.3NP_001099133.1  peroxisomal coenzyme A diphosphatase NUDT7 isoform 1

    See identical proteins and their annotated locations for NP_001099133.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AI927964, AK296963, BU579534, BX387030
    Consensus CDS
    CCDS42195.1
    UniProtKB/Swiss-Prot
    P0C024
    Related
    ENSP00000268533.5, ENST00000268533.9
    Conserved Domains (1) summary
    cd03426
    Location:41201
    CoAse; Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative ...
  2. NM_001243657.1NP_001230586.1  peroxisomal coenzyme A diphosphatase NUDT7 isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) includes an alternate exon in the coding region, which results in a frameshift, compared to variant 1. The encoded isoform (3) is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AI927964, AK296963, BX387030, CN297379
    Consensus CDS
    CCDS58479.1
    UniProtKB/Swiss-Prot
    P0C024
    Related
    ENSP00000457566.1, ENST00000564085.5
    Conserved Domains (1) summary
    cd03426
    Location:41115
    CoAse; Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative ...
  3. NM_001243660.1NP_001230589.1  peroxisomal coenzyme A diphosphatase NUDT7 isoform 4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks an exon and contains an alternate exon in the coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (4) is shorter than isoform 1.
    Source sequence(s)
    AC092724, AI927964, AK296963, BX387030
    Consensus CDS
    CCDS73916.1
    UniProtKB/Swiss-Prot
    P0C024
    UniProtKB/TrEMBL
    A0A087WVP7
    Related
    ENSP00000479582.1, ENST00000613075.4
    Conserved Domains (1) summary
    cl00447
    Location:41186
    Nudix_Hydrolase; Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+ ...
  4. NM_001243661.1NP_001230590.1  peroxisomal coenzyme A diphosphatase NUDT7 isoform 2

    See identical proteins and their annotated locations for NP_001230590.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an exon in the coding region but maintains the reading frame, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AI927964, AK296963, BX387030
    Consensus CDS
    CCDS58480.1
    UniProtKB/Swiss-Prot
    P0C024
    Related
    ENSP00000387707.3, ENST00000437314.3
    Conserved Domains (1) summary
    cl00447
    Location:41148
    Nudix_Hydrolase; Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+ ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p13 Primary Assembly

    Range
    77722492..77742260
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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