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INO80E INO80 complex subunit E [ Homo sapiens (human) ]

Gene ID: 283899, updated on 9-Feb-2020

Summary

Official Symbol
INO80Eprovided by HGNC
Official Full Name
INO80 complex subunit Eprovided by HGNC
Primary source
HGNC:HGNC:26905
See related
Ensembl:ENSG00000169592
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CCDC95
Expression
Ubiquitous expression in testis (RPKM 18.0), spleen (RPKM 15.7) and 25 other tissues See more
Orthologs

Genomic context

See INO80E in Genome Data Viewer
Location:
16p11.2
Exon count:
10
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 16 NC_000016.10 (29995690..30005791)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (30007485..30017112)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene transmembrane protein 219 Neighboring gene TAO kinase 2 Neighboring gene HIRA interacting protein 3 Neighboring gene double C2 domain alpha Neighboring gene chromosome 16 open reading frame 92 Neighboring gene TLC domain containing 3B Neighboring gene uncharaterized LOC112694756 Neighboring gene aldolase, fructose-bisphosphate A

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of INO80 complex subunit E (INO80E) by siRNA enhances the early stages of HIV-1 replication in HeLa-CD4 cells infected with viral pseudotypes HIV89.6R and HIV8.2N PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ00079, FLJ90652

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
DNA recombination IEA
Inferred from Electronic Annotation
more info
 
DNA repair IEA
Inferred from Electronic Annotation
more info
 
chromatin remodeling IEA
Inferred from Electronic Annotation
more info
 
protein deubiquitination TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
Ino80 complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Ino80 complex IDA
Inferred from Direct Assay
more info
PubMed 
nucleolus IDA
Inferred from Direct Assay
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
INO80 complex subunit E
Names
coiled-coil domain containing 95
coiled-coil domain-containing protein 95

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001304562.2NP_001291491.1  INO80 complex subunit E isoform 2

    See identical proteins and their annotated locations for NP_001291491.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AC093512, AL525020, BC047712, BI093312
    Consensus CDS
    CCDS76853.1
    UniProtKB/Swiss-Prot
    Q8NBZ0
    UniProtKB/TrEMBL
    J3KNE2
    Related
    ENSP00000303977.7, ENST00000304516.11
    Conserved Domains (1) summary
    pfam08537
    Location:1265
    NBP1; Fungal Nap binding protein NBP1
  2. NM_001304563.2NP_001291492.1  INO80 complex subunit E isoform 3

    See identical proteins and their annotated locations for NP_001291492.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) contains an alternate exon in the 3' end compared to variant 1. The resulting isoform (3) has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AC093512, AL525020, BC047712, BU528528
    UniProtKB/Swiss-Prot
    Q8NBZ0
  3. NM_173618.3NP_775889.1  INO80 complex subunit E isoform 1

    See identical proteins and their annotated locations for NP_775889.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AC093512, AK075133, BC047712
    Consensus CDS
    CCDS10665.1
    UniProtKB/Swiss-Prot
    Q8NBZ0
    Related
    ENSP00000457016.1, ENST00000563197.6

RNA

  1. NR_130786.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) uses an alternate splice junction at the 5' end of an internal exon and contains an alternate exon in the 3' end compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC093512, AL525020, BC047712, BM924992, BX356644
    Related
    ENST00000562441.5
  2. NR_130787.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) uses an alternate splice junction at the 5' end of an internal exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC093512, AL525020, BC047712, BM924992
  3. NR_134855.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) contains four alternate internal exons, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AL525020, BC035693
    Related
    ENST00000567987.5

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p13 Primary Assembly

    Range
    29995690..30005791
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011545809.3XP_011544111.1  INO80 complex subunit E isoform X2

    Related
    ENSP00000461808.1, ENST00000567254.5
  2. XM_024450238.1XP_024306006.1  INO80 complex subunit E isoform X1

  3. XM_024450237.1XP_024306005.1  INO80 complex subunit E isoform X1

  4. XM_011545812.3XP_011544114.1  INO80 complex subunit E isoform X4

  5. XM_017023169.2XP_016878658.1  INO80 complex subunit E isoform X1

  6. XM_024450236.1XP_024306004.1  INO80 complex subunit E isoform X1

  7. XM_011545811.3XP_011544113.1  INO80 complex subunit E isoform X3

    See identical proteins and their annotated locations for XP_011544113.1

RNA

  1. XR_001751894.2 RNA Sequence

  2. XR_002957799.1 RNA Sequence

  3. XR_002957798.1 RNA Sequence

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