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CES4A carboxylesterase 4A [ Homo sapiens (human) ]

Gene ID: 283848, updated on 1-Jun-2020

Summary

Official Symbol
CES4Aprovided by HGNC
Official Full Name
carboxylesterase 4Aprovided by HGNC
Primary source
HGNC:HGNC:26741
See related
Ensembl:ENSG00000172824
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CES6; CES8
Summary
This gene encodes a member of the carboxylesterase large family. The family members are responsible for the hydrolysis or transesterification of various xenobiotics, such as cocaine and heroin, and endogenous substrates with ester, thioester, or amide bonds. They also participate in fatty acyl and cholesterol ester metabolism, and may play a role in the blood-brain barrier system. This gene, also called CES6, encodes a secreted enzyme, and may play a role in the detoxification of drugs and xenobiotics in neural and other tissues of the body and in the cerebrospinal fluid. Multiple transcript variants encoding different isoforms have been reported, but the full-length nature and/or biological validity of some variants have not been determined. [provided by RefSeq, Jun 2010]
Expression
Broad expression in skin (RPKM 14.9), brain (RPKM 5.0) and 21 other tissues See more
Orthologs

Genomic context

See CES4A in Genome Data Viewer
Location:
16q22.1
Exon count:
16
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 16 NC_000016.10 (66988589..67010417)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (67022491..67043661)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107984881 Neighboring gene Sharpr-MPRA regulatory region 4953 Neighboring gene carboxylesterase 3 Neighboring gene RNA, 7SL, cytoplasmic 543, pseudogene Neighboring gene core-binding factor subunit beta

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ37002, FLJ37464

Gene Ontology Provided by GOA

Function Evidence Code Pubs
carboxylic ester hydrolase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
sterol esterase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
triglyceride lipase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
lipid catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
carboxylesterase 4A
Names
carboxylesterase 6
carboxylesterase 8 (putative)
NP_001177130.1
NP_001177131.1
NP_001305435.1
NP_001351711.1
NP_776176.5
XP_011521323.1
XP_011521325.1
XP_011521326.1
XP_011521327.1
XP_011521328.1
XP_011521329.1
XP_011521330.1
XP_011521331.1
XP_011521332.1
XP_016878649.1
XP_016878650.1
XP_016878651.1
XP_016878652.1
XP_016878653.1
XP_016878654.1
XP_016878655.1
XP_016878657.1
XP_024306002.1
XP_024306003.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001190201.2NP_001177130.1  carboxylesterase 4A isoform 3

    See identical proteins and their annotated locations for NP_001177130.1

    Status: REVIEWED

    Source sequence(s)
    AC009084, AK300792, BC029039, DC306014
    Consensus CDS
    CCDS54024.1
    UniProtKB/Swiss-Prot
    Q5XG92
    Related
    ENSP00000441907.1, ENST00000540579.6
    Conserved Domains (2) summary
    COG0657
    Location:23126
    Aes; Acetyl esterase/lipase [Lipid transport and metabolism]
    pfam00135
    Location:14448
    COesterase; Carboxylesterase family
  2. NM_001190202.2NP_001177131.1  carboxylesterase 4A isoform 4

    See identical proteins and their annotated locations for NP_001177131.1

    Status: REVIEWED

    Source sequence(s)
    AC009084, AK295483, BC064573, DC306014
    Consensus CDS
    CCDS54025.1
    UniProtKB/Swiss-Prot
    Q5XG92
    UniProtKB/TrEMBL
    Q6P2E5
    Related
    ENSP00000441644.1, ENST00000535696.1
    Conserved Domains (2) summary
    COG0657
    Location:23130
    Aes; Acetyl esterase/lipase [Lipid transport and metabolism]
    cl21494
    Location:14345
    Abhydrolase; alpha/beta hydrolases
  3. NM_001318506.2NP_001305435.1  carboxylesterase 4A isoform 5

    Status: REVIEWED

    Source sequence(s)
    AC009084, AK094783, AK293061, CD369737, DC306014
    UniProtKB/Swiss-Prot
    Q5XG92
    Conserved Domains (1) summary
    cl21494
    Location:2352
    Abhydrolase; alpha/beta hydrolases
  4. NM_001364782.1NP_001351711.1  carboxylesterase 4A isoform 6 precursor

    Status: REVIEWED

    Source sequence(s)
    AC009084
    Related
    ENSP00000497868.2, ENST00000648724.2
    Conserved Domains (1) summary
    pfam00135
    Location:27546
    COesterase; Carboxylesterase family
  5. NM_173815.7NP_776176.5  carboxylesterase 4A isoform 1 precursor

    Status: REVIEWED

    Source sequence(s)
    AC009084, AK295483, AK296064, CD369737, DC339496
    Consensus CDS
    CCDS42174.3
    UniProtKB/Swiss-Prot
    Q5XG92
    Related
    ENSP00000444052.2, ENST00000540947.6
    Conserved Domains (2) summary
    COG0657
    Location:121224
    Aes; Acetyl esterase/lipase [Lipid transport and metabolism]
    pfam00135
    Location:23439
    COesterase; Carboxylesterase family

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p13 Primary Assembly

    Range
    66988589..67010417
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011523021.2XP_011521323.1  carboxylesterase 4A isoform X1

    Conserved Domains (2) summary
    COG0657
    Location:184291
    Aes; Acetyl esterase/lipase [Lipid transport and metabolism]
    pfam00135
    Location:46613
    COesterase; Carboxylesterase family
  2. XM_011523027.2XP_011521329.1  carboxylesterase 4A isoform X8

    Conserved Domains (2) summary
    COG0657
    Location:184291
    Aes; Acetyl esterase/lipase [Lipid transport and metabolism]
    pfam00135
    Location:46570
    COesterase; Carboxylesterase family
  3. XM_011523029.2XP_011521331.1  carboxylesterase 4A isoform X15

    Conserved Domains (2) summary
    COG0657
    Location:184291
    Aes; Acetyl esterase/lipase [Lipid transport and metabolism]
    pfam00135
    Location:46506
    COesterase; Carboxylesterase family
  4. XM_011523025.2XP_011521327.1  carboxylesterase 4A isoform X4

    Conserved Domains (2) summary
    COG0657
    Location:184291
    Aes; Acetyl esterase/lipase [Lipid transport and metabolism]
    pfam00135
    Location:46586
    COesterase; Carboxylesterase family
  5. XM_017023163.1XP_016878652.1  carboxylesterase 4A isoform X13

  6. XM_017023166.1XP_016878655.1  carboxylesterase 4A isoform X18

  7. XM_011523023.2XP_011521325.1  carboxylesterase 4A isoform X2

    Conserved Domains (2) summary
    COG0657
    Location:184287
    Aes; Acetyl esterase/lipase [Lipid transport and metabolism]
    pfam00135
    Location:46609
    COesterase; Carboxylesterase family
  8. XM_017023161.1XP_016878650.1  carboxylesterase 4A isoform X10

  9. XM_017023165.1XP_016878654.1  carboxylesterase 4A isoform X16

  10. XM_017023160.1XP_016878649.1  carboxylesterase 4A isoform X6

  11. XM_017023164.1XP_016878653.1  carboxylesterase 4A isoform X14

  12. XM_011523026.2XP_011521328.1  carboxylesterase 4A isoform X7

    Conserved Domains (2) summary
    COG0657
    Location:144251
    Aes; Acetyl esterase/lipase [Lipid transport and metabolism]
    pfam00135
    Location:46573
    COesterase; Carboxylesterase family
  13. XM_011523030.2XP_011521332.1  carboxylesterase 4A isoform X17

    Related
    ENSP00000441103.1, ENST00000538199.5
    Conserved Domains (2) summary
    COG0657
    Location:144247
    Aes; Acetyl esterase/lipase [Lipid transport and metabolism]
    pfam00135
    Location:46499
    COesterase; Carboxylesterase family
  14. XM_011523024.2XP_011521326.1  carboxylesterase 4A isoform X3

    Conserved Domains (2) summary
    COG0657
    Location:184291
    Aes; Acetyl esterase/lipase [Lipid transport and metabolism]
    pfam00135
    Location:46549
    COesterase; Carboxylesterase family
  15. XM_017023162.1XP_016878651.1  carboxylesterase 4A isoform X12

  16. XM_024450234.1XP_024306002.1  carboxylesterase 4A isoform X5

    Conserved Domains (1) summary
    pfam00135
    Location:50545
    COesterase; Carboxylesterase family
  17. XM_011523028.2XP_011521330.1  carboxylesterase 4A isoform X11

    Conserved Domains (2) summary
    COG0657
    Location:132239
    Aes; Acetyl esterase/lipase [Lipid transport and metabolism]
    pfam00135
    Location:34561
    COesterase; Carboxylesterase family
  18. XM_017023168.1XP_016878657.1  carboxylesterase 4A isoform X19

  19. XM_024450235.1XP_024306003.1  carboxylesterase 4A isoform X20

    Conserved Domains (1) summary
    cl21494
    Location:8314
    Abhydrolase; alpha/beta hydrolases
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