Format

Send to:

Choose Destination

NOMO2 NODAL modulator 2 [ Homo sapiens (human) ]

Gene ID: 283820, updated on 12-May-2019

Summary

Official Symbol
NOMO2provided by HGNC
Official Full Name
NODAL modulator 2provided by HGNC
Primary source
HGNC:HGNC:22652
See related
Ensembl:ENSG00000185164 MIM:609158
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PM5; Nomo
Summary
This gene encodes a protein originally thought to be related to the collagenase gene family. This gene is one of three highly similar genes in a region of duplication located on the p arm of chromosome 16. These three genes encode closely related proteins that may have the same function. The protein encoded by one of these genes has been identified as part of a protein complex that participates in the Nodal signaling pathway during vertebrate development. Mutations in ABCC6, which is located nearby, rather than mutations in this gene are associated with pseudoxanthoma elasticum (PXE). Two transcripts encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
Annotation information
Annotation category: suggests misassembly
Expression
Ubiquitous expression in brain (RPKM 58.0), heart (RPKM 50.7) and 25 other tissues See more
Orthologs

Genomic context

See NOMO2 in Genome Data Viewer
Location:
16p12.3
Exon count:
33
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 16 NC_000016.10 (18499924..18562143, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (18511182..18573434, complement)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105379460 Neighboring gene microRNA 3670-4 Neighboring gene microRNA 3179-4 Neighboring gene ATP binding cassette subfamily C member 6 pseudogene 1 Neighboring gene ribosomal protein S15a

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
carbohydrate binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
endoplasmic reticulum membrane IDA
Inferred from Direct Assay
more info
PubMed 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
protein-containing complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
nodal modulator 2
Names
pM5 protein 2
pM5 protein, centromeric copy

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001004060.1NP_001004060.1  nodal modulator 2 isoform 1 precursor

    See identical proteins and their annotated locations for NP_001004060.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the shorter transcript but encodes the longer isoform (1).
    Source sequence(s)
    BC028389, BC041131, BG830626
    Consensus CDS
    CCDS32394.1
    UniProtKB/Swiss-Prot
    Q5JPE7
    Related
    ENSP00000477502.1, ENST00000621364.4
    Conserved Domains (2) summary
    pfam05738
    Location:875927
    Cna_B; Cna protein B-type domain
    pfam13620
    Location:330404
    CarboxypepD_reg; Carboxypeptidase regulatory-like domain
  2. NM_173614.2NP_775885.1  nodal modulator 2 isoform 2 precursor

    See identical proteins and their annotated locations for NP_775885.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) contains an alternate segment in the 3' CDS, compared to variant 1. The resulting protein (isoform 2) is shorter and has a distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AL832855, BC013837, BC041131, BG830626
    Consensus CDS
    CCDS10570.1
    UniProtKB/Swiss-Prot
    Q5JPE7
    Related
    ENSP00000478653.1, ENST00000622306.4
    Conserved Domains (2) summary
    pfam05738
    Location:875927
    Cna_B; Cna protein B-type domain
    pfam13620
    Location:330404
    CarboxypepD_reg; Carboxypeptidase regulatory-like domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p12 Primary Assembly

    Range
    18499924..18562143 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017023156.2XP_016878645.1  nodal modulator 2 isoform X1

Support Center