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GPR15 G protein-coupled receptor 15 [ Homo sapiens (human) ]

Gene ID: 2838, updated on 8-Jul-2021

Summary

Official Symbol
GPR15provided by HGNC
Official Full Name
G protein-coupled receptor 15provided by HGNC
Primary source
HGNC:HGNC:4469
See related
Ensembl:ENSG00000154165 MIM:601166
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
BOB
Summary
This gene encodes a G protein-coupled receptor that acts as a chemokine receptor for human immunodeficiency virus type 1 and 2. The encoded protein localizes to the cell membrane. [provided by RefSeq, Nov 2012]
Orthologs
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Genomic context

See GPR15 in Genome Data Viewer
Location:
3q11.2
Exon count:
1
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (98531978..98534681)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (98250822..98253525)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene claudin domain containing 1 Neighboring gene RPL38 pseudogene 4 Neighboring gene coproporphyrinogen oxidase Neighboring gene ribosomal protein L19 pseudogene 7

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 ZP6248 T/F virus efficiently uses an alternative coreceptor GPR15 to establish clinical infection, and gp120 G306A, V307A, E314A, K315A, V316A, Y317A, F318A and S322A mutations significantly reduce or abolish the replication capacity in GPR15+ cells PubMed
env HIV gp120-induced calcium signaling, microtubule loss, and physiological changes on HT-29 cells are inhibited by anti-Bob/GPR15 neutralizing antibodies, suggesting that gp120-induced Bob/GRP15 activation is a plausible cause of HIV enteropathy PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC126828, MGC126830

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G protein-coupled receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables G protein-coupled receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables coreceptor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables virus receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in G protein-coupled receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in T cell migration IEA
Inferred from Electronic Annotation
more info
 
involved_in viral entry into host cell IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in endosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in integral component of plasma membrane TAS
Traceable Author Statement
more info
PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
G-protein coupled receptor 15
Names
brother of Bonzo

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_005290.4NP_005281.1  G-protein coupled receptor 15

    See identical proteins and their annotated locations for NP_005281.1

    Status: REVIEWED

    Source sequence(s)
    AA687817, AC021660, AK313375, BC101779
    Consensus CDS
    CCDS2931.1
    UniProtKB/Swiss-Prot
    P49685
    UniProtKB/TrEMBL
    B2R8H6, B6V9G9
    Related
    ENSP00000284311.3, ENST00000284311.5
    Conserved Domains (1) summary
    cd15194
    Location:34313
    7tmA_GPR15; G protein-coupled receptor 15, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

    Range
    98531978..98534681
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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