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PLA2G4D phospholipase A2 group IVD [ Homo sapiens (human) ]

Gene ID: 283748, updated on 25-Nov-2021

Summary

Official Symbol
PLA2G4Dprovided by HGNC
Official Full Name
phospholipase A2 group IVDprovided by HGNC
Primary source
HGNC:HGNC:30038
See related
Ensembl:ENSG00000159337 MIM:612864
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
cPLA2delta
Summary
The phospholipase A2 enzyme family, including PLA2G4D, catalyze the hydrolysis of glycerophospholipids at the sn-2 position and then liberate free fatty acids and lysophospholipids (Chiba et al., 2004 [PubMed 14709560]).[supplied by OMIM, Jun 2009]
Expression
Biased expression in skin (RPKM 6.8), prostate (RPKM 6.7) and 2 other tissues See more
Orthologs
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Genomic context

See PLA2G4D in Genome Data Viewer
Location:
15q15.1
Exon count:
21
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 15 NC_000015.10 (42067009..42094562, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (42359207..42386760, complement)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene PLA2G4E antisense RNA 1 Neighboring gene phospholipase A2 group IVE Neighboring gene uncharacterized LOC105370793 Neighboring gene phospholipase A2 group IVF Neighboring gene VPS39 subunit of HOPS complex Neighboring gene microRNA 627

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 gp120 causes an activation of phospholipase A2, resulting in the increased release of arachidonic acid, which may sensitize the NMDA receptor PubMed
env HIV-1 gp120 induces a specific phospholipase A2 (PLA2) activation in lymphocytes through binding to CD4, but this effect is not sufficient to accomplish virus/cell fusion PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables calcium ion binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables calcium-dependent phospholipase A2 activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables calcium-dependent phospholipase A2 activity IDA
Inferred from Direct Assay
more info
PubMed 
enables calcium-dependent phospholipid binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables phospholipase A1 activity TAS
Traceable Author Statement
more info
 
enables phospholipase A2 activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
cytosolic phospholipase A2 delta
Names
cPLA2-delta
phospholipase A2 delta, cytosolic
phospholipase A2, group IVD (cytosolic)
NP_828848.3
XP_011519769.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_178034.4NP_828848.3  cytosolic phospholipase A2 delta

    See identical proteins and their annotated locations for NP_828848.3

    Status: VALIDATED

    Source sequence(s)
    AB090876, AC084693
    Consensus CDS
    CCDS32203.1
    UniProtKB/Swiss-Prot
    Q86XP0
    Related
    ENSP00000290472.3, ENST00000290472.4
    Conserved Domains (2) summary
    cd07201
    Location:269811
    cPLA2_Grp-IVB-IVD-IVE-IVF; Group IVB, IVD, IVE, and IVF cytosolic phospholipase A2; catalytic domain; Ca-dependent
    cd04036
    Location:23141
    C2_cPLA2; C2 domain present in cytosolic PhosphoLipase A2 (cPLA2)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p13 Primary Assembly

    Range
    42067009..42094562 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011521467.2XP_011519769.1  cytosolic phospholipase A2 delta isoform X1

    Conserved Domains (2) summary
    cd07201
    Location:213755
    cPLA2_Grp-IVB-IVD-IVE-IVF; Group IVB, IVD, IVE, and IVF cytosolic phospholipase A2; catalytic domain; Ca-dependent
    cl14603
    Location:185
    C2; C2 domain

RNA

  1. XR_931798.2 RNA Sequence

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