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FAM177A1 family with sequence similarity 177 member A1 [ Homo sapiens (human) ]

Gene ID: 283635, updated on 7-Jun-2020

Summary

Official Symbol
FAM177A1provided by HGNC
Official Full Name
family with sequence similarity 177 member A1provided by HGNC
Primary source
HGNC:HGNC:19829
See related
Ensembl:ENSG00000151327
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
C14orf24
Summary
This gene encodes a member of a conserved protein family. Alternative splicing results in multiple transcript variants. This gene is thought to be associated with susceptibility to juvenile idiopathic arthritis. [provided by RefSeq, Apr 2017]
Expression
Ubiquitous expression in prostate (RPKM 15.8), colon (RPKM 14.8) and 25 other tissues See more
Orthologs

Genomic context

See FAM177A1 in Genome Data Viewer
Location:
14q13.2
Exon count:
8
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 14 NC_000014.9 (35044907..35083383)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (35514113..35552589)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene SRP54 antisense RNA 1 (head to head) Neighboring gene immunoglobulin (CD79A) binding protein 1 pseudogene 1 Neighboring gene signal recognition particle 54 Neighboring gene uncharacterized LOC101927178 Neighboring gene protein phosphatase 2 regulatory subunit B''gamma Neighboring gene protein only RNase P catalytic subunit Neighboring gene ribosomal protein L23a pseudogene 70

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ38854, DKFZp686J1254

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_054633.1 RefSeqGene

    Range
    5001..43477
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001079519.1NP_001072987.1  protein FAM177A1 isoform 2

    See identical proteins and their annotated locations for NP_001072987.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon compared to variant 1. The resulting protein (isoform 2) has a shorter N-terminus compared to isoform 1. Variants 2 and 3 encode the same isoform.
    Source sequence(s)
    AI148967, AL049776, AL833508, BX640884
    Consensus CDS
    CCDS41944.1
    UniProtKB/Swiss-Prot
    Q8N128
    Related
    ENSP00000379734.1, ENST00000396472.5
    Conserved Domains (1) summary
    pfam14774
    Location:41144
    FAM177; FAM177 family
  2. NM_001289022.2NP_001275951.1  protein FAM177A1 isoform 2

    See identical proteins and their annotated locations for NP_001275951.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon compared to variant 1. The resulting protein (isoform 2) has a shorter N-terminus compared to isoform 1. Variants 2 and 3 encode the same isoform.
    Source sequence(s)
    AL049776, BG700755, BX640884, CD678775
    Consensus CDS
    CCDS41944.1
    UniProtKB/Swiss-Prot
    Q8N128
    Related
    ENSP00000371843.3, ENST00000382406.7
    Conserved Domains (1) summary
    pfam14774
    Location:41144
    FAM177; FAM177 family
  3. NM_173607.5NP_775878.2  protein FAM177A1 isoform 1 precursor

    See identical proteins and their annotated locations for NP_775878.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer protein (isoform 1).
    Source sequence(s)
    AL049776, BX640884
    Consensus CDS
    CCDS9653.2
    UniProtKB/Swiss-Prot
    Q8N128
    Related
    ENSP00000280987.4, ENST00000280987.8
    Conserved Domains (1) summary
    pfam14774
    Location:64167
    FAM177; FAM177 family

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p13 Primary Assembly

    Range
    35044907..35083383
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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